Results 31 to 40 of about 5,258 (134)

Facilitating the timely diagnosis of Lennox–Gastaut syndrome: A checklist to support clinical practice

Epileptic Disorders, EarlyView.
Abstract Objective To develop and evaluate a simple‐to‐use checklist to support physicians with the timely diagnosis of Lennox–Gastaut syndrome (LGS). Methods A panel of 10 pediatric and adult epileptologists used the International League Against Epilepsy (ILAE) criteria for LGS classification and definition to develop seven questions for the checklist,
Nicola Specchio, Alexis Arzimanoglou, Stéphane Auvin, Antonio Gil‐Nagel, Lieven Lagae, Rima Nabbout, Susanne Schubert‐Bast, Adam Strzelczyk, Eugen Trinka, J. Helen Cross   +9 more
wiley   +1 more source

Das Verfahren der anwendungsbegleitenden Datenerhebung für die frühe Nutzenbewertung

Monitor Versorgungsforschung
Am 16. August 2019 trat das Gesetz für mehr Sicherheit in der Arzneimittelversorgung (GSAV) in Kraft. Es wurden Änderungen in § 35a SGB V vorgenommen, die es dem Gemeinsamen Bundesausschuss (G-BA) ermöglichen, bei Arzneimitteln zur Behandlung eines ...
Dr. rer. nat. Florian Jantschak, Dr. med. Katharina Wenzel-Seifert, Dr. rer. nat. Tilman Broicher, Dr. med. Maike Schier   +3 more
doaj   +1 more source

Spontaneous long-term and urethane induced hippocampal EEG power, activity and temperature data from mice lacking the Cav3.2 voltage-gated Ca2+ channel

Data in Brief, 2021
This article provides raw relative electroencephalographic (EEG) power, temperature and activity data from controls and Cav3.2 deficient mice. Radiotransmitter implantation was carried out in male experimental mice under ketamine/xylazine narcosis ...
Anna Papazoglou, Muhammad Imran Arshaad, Magdalena Elisabeth Siwek, Christina Henseler, Johanna Daubner, Dan Ehninger, Jürgen Hescheler, Karl Broich, Marco Weiergräber   +8 more
doaj   +1 more source

Hippocampal network activity changes during early epileptogenesis predict subsequent epilepsy

Epilepsia, EarlyView.
Abstract Objective Despite decades of research, the circuit mechanisms that underlie focal epileptogenesis remain incompletely understood. In this study, we aimed to characterize the changes in hippocampal network activity induced by an epileptogenic insult.
Michael Strüber, Tristan Manfred Stöber, Vanessa Schütz, Lara Costard, Valentin Neubert, Sebastian Bauer, Parsa Gharavi, Julika Pitsch, Nico Melzer, Adam Strzelczyk, Jochen Triesch, Kai Siebenbrodt, Felix Rosenow, Ricardo Kienitz   +13 more
wiley   +1 more source

Diet–Microbiome–Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications

Allergy, EarlyView.
ABSTRACT Mucosal surfaces are sites of highly dynamic interactions among epithelial and immune cells, environmental exposures, particularly dietary inputs, and the diverse microbial communities and their metabolites. These elements continually influence each other to maintain homeostasis and ensure appropriate immune discrimination between pathogens ...
Clara Delaroque, Liam O'Mahony, Inge Kortekaas Krohn, Charlotte G. Mortz, Markus Ollert, Mahesh S. Desai   +5 more
wiley   +1 more source

Intra-Seasonal Initiation of the SQ-Standardised Grass Allergy Immunotherapy Tablet Routinely Applied by Allergy Specialists and General Practitioners with Experience in Treatment of Allergy: A Non-Interventional Observational Study

Pulmonary Therapy, 2018
Introduction Intra-seasonal start of treatment with the SQ® grass sublingual immunotherapy(SLIT) tablet (GRAZAX®, ALK, Denmark) has been previously demonstrated to be well-tolerated. The objective of our study was to investigate the tolerability of intra-
Jan-Alexander Schwab, Hendrik Wolf, Jörg Schnitker, Eike Wüstenberg   +3 more
doaj   +1 more source

PA-Kontaminationen in Arzneipflanzen: Vorkommen, Grenzwerte und Maßnahmen

Journal für Kulturpflanzen, 2020
Seit mehreren Jahren wird eine mögliche Kontamination von Arzneipflanzen mit pyrrolizidinalkaloid-haltigen Beikräutern diskutiert. Die Erkenntnisse über ein solches Risiko hat die Anbauer und Lieferanten pflanzlicher Drogen und die Hersteller von ...
Barbara Steinhoff
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Vascular Dynamics During Respiratory Arousal From Sleep Assessed by Oximeter‐Based Vascular Stiffness Measures

Journal of Sleep Research, EarlyView.
ABSTRACT Cortical arousals significantly impact obstructive sleep apnoea (OSA) pathophysiology and cardiovascular consequences, often mediated by sympathetic activation. While pulse oximetry (PPG) provides an accessible reflection of autonomic responses such as changes in pulse rate (PR) and pulse wave amplitude (PWA), the dynamic influence on other ...
Christian Strassberger, Ding Zou, Jan Hedner, Ludger Grote   +3 more
wiley   +1 more source

Steroid Sparing Effect of 300IR House Dust Mite Sublingual Immunotherapy Tablet in Mite Allergic Rhinitis

Clinical and Translational Allergy, Volume 16, Issue 8, August 2026.
ABSTRACT Background In a large randomized controlled trial (NCT02443805) in moderate‐to‐severe house dust mite (HDM) allergic rhinitis (AR) patients with/without controlled asthma, the 300IR HDM sublingual immunotherapy (SLIT) tablet confirmed its efficacy in reducing symptoms and rescue medication (RM) use.
Oliver Pfaar, Pascal Demoly, Philippe Gevaert, Ludger Klimek, Carmen Vidal, Margitta Worm, Randolf Brehler, Thomas B. Casale, Giorgio Walter Canonica   +8 more
wiley   +1 more source