Results 61 to 70 of about 30,414 (210)

Gender specific hippocampal whole genome transcriptome data from mice lacking the Cav2.3 R-type or Cav3.2 T-type voltage-gated calcium channel

Data in Brief, 2017
Voltage-gated Ca2+ channels are of central relevance in mediating numerous intracellular and transcellular processes including excitation-contraction coupling, excitation secretion-coupling, hormone and neurotransmitter release and gene expression.
Anna Papazoglou, Christina Henseler, Andreas Lundt, Carola Wormuth, Julien Soos, Karl Broich, Dan Ehninger, Marco Weiergräber   +7 more
doaj   +1 more source

Phenobarbital Bioequivalence in Chinese Population: Considering the Role of Food on Pharmacokinetics

Clinical Pharmacology in Drug Development, Volume 14, Issue 12, Page 925-933, December 2025.
Abstract Epilepsy is one of the most severe neurological disorders in the world, which might seriously endanger the lives of patients. Phenobarbital is an important medicine clinically used for the treatment of epilepsy, and it is irreplaceable in the treatment of generalized tonic–clonic seizures, focal seizures, status epilepticus, and pediatric ...
Wang Xinman, Liu Yuan, Sun Ying, Wang Yiyun   +3 more
wiley   +1 more source

Seizures beget more than seizures: Understanding the cellular, structural, individual and societal impact of seizures in epilepsy

Epilepsia Open, Volume 10, Issue 6, Page 1762-1773, December 2025.
Abstract Epilepsy is primarily defined by the repetitive occurrence of seizures, but the full impact of seizures extends beyond these episodic events. Seizures themselves cause changes at the cellular, network, and systemic levels in individual patients with epilepsy and may contribute to the progressive nature of the disease in some patients. Seizures
Matthew C. Walker, Marian Galovic, Elena Álvarez‐Barón, Adam Strzelczyk   +3 more
wiley   +1 more source

Effectiveness of a Combination of Nasturtium Herb and Horseradish Root (Angocin^® Anti-Infekt N) Compared to Antibiotics in Managing Acute and Recurrent Urinary Tract Infections: A Retrospective Real-world Cohort Study

Antibiotics
Background: The goal of this study was to evaluate whether the medical recommendation of Angocin® Anti-Infekt N, compared to standard antibiotic treatment shortly after the diagnosis of a urinary tract infection (UTI) or cystitis, is negatively ...
Nina Kassner, Meinolf Wonnemann, Yvonne Ziegler, Winfried Vahlensieck, Jennifer Kranz, Karel Kostev   +5 more
doaj   +1 more source

Handbook Communication Strategies for Sharpening Environmental Awareness in the Handling of Pharmaceutical Drugs : German Federal Environmental Agency Research Project 37 08 61 400 [PDF]

, 2011
In Deutschland und in fast allen Industrieländern finden sich mittlerweile Medikamentenwirkstoffe in nahezu allen Gewässern und vereinzelt auch im Trinkwasser.
Benzing, Corinne, Deffner, Jutta, Götz, Konrad, Keil, Florian   +3 more
core  

Key Stakeholders' Knowledge, Opinions, and Interests on Real‐World Evidence in the Regulatory Process—Results of an EU‐Wide Survey

Clinical and Translational Science, Volume 18, Issue 12, December 2025.
ABSTRACT Real‐world data (RWD) and real‐world evidence (RWE) are increasingly gaining attention in supporting drug regulatory decision making. This study assessed knowledge, opinions, and usage patterns of key stakeholders regarding the status of RWD/RWE and AI implementation in health technology assessment (HTA) and drug regulation and aimed to ...
Frank Lucas Depner, Martin Russek, Christoph Röthlein, Cornelia Becker, Jonas Peltner, Kerstin Pfeifer, Evy Reviers, Dirk De Valck, Julia Wicherski, Sirpa Hartikainen, Anna‐Maija Tolppanen, Britta Haenisch   +11 more
wiley   +1 more source

Sleep quality and its correlates in people with epilepsy: A multicenter cross‐sectional study in Germany

Epilepsia, Volume 66, Issue 12, Page 4764-4779, December 2025.
Abstract Objective Sleep disturbances and epilepsy are closely interrelated. This study aimed to examine associations between sleep quality, affective symptoms, and quality of life (QoL) in people with epilepsy (PWE), and to identify clinical and sociodemographic factors linked to impaired sleep. Methods We conducted a multicenter cross‐sectional study
Johann Philipp Zöllner, Catrin Mann, Laurent Willems, Felix von Podewils, Lisa Langenbruch, Laura Bierhansl, Susanne Knake, Katja Menzler, Juliane Schulz, Bernadette Gaida, Felix Rosenow, Adam Strzelczyk   +11 more
wiley   +1 more source

Evidenzbasierte Bestimmung des Leistungskatalogs im Gesundheitswesen? Das Beispiel des englischen National Institute for Clinical Excellence (NICE) [PDF]

, 2004
Das englische National Institute for Clinical Excellence (NICE) wird in der bundesdeutschen Diskussion um die Reform der Institutionen zur Konkretisierung des Leistungskatalogs in der GKV entweder als Vorbild oder als abschreckendes Beispiel genannt. Die
Greß, Stefan, Niebuhr, Dea, Rothgang, Heinz, Wasem, Jürgen   +3 more
core  

Allergologische Diagnostik von Überempfindlichkeitsreaktionen auf Arzneimittel [PDF]

, 2008
Drug hypersensitivity reactions have to be tested to identify the culprit substance. The history includes the general information and specific data concerning used drugs, the classification and circumstances of the reaction.
Aberer, Werner, Bircher, Andreas J., Brehler, Randolph, Brockow, Knut, Dickel, Heinrich, Fuchs, Thomas, Hertl, Michael, Merk, Hans F., Mockenhaupt, Maja, Pfaar, Oliver, Przybilla, Bernhard, Ring, Johannes, Sachs, Bernhardt, Vieluf, Dieter, Wedi, Bettina, Worm, Margitta, Zuberbier, Torsten   +16 more
core   +1 more source

Peri‐ictal imaging abnormalities in non‐convulsive status epilepticus: A systematic review and meta‐analysis comparing magnetic resonance imaging and computed tomography perfusion

Epilepsia, Volume 66, Issue 12, Page 4895-4909, December 2025.
Abstract Objective To assess and compare the detection rates of peri‐ictal abnormalities using magnetic resonance imaging (MRI) and computed tomography perfusion (CTP) in patients with non‐convulsive status epilepticus (NCSE). Methods We conducted a systematic literature search in five databases up to February 2025.
Pilar Bosque‐Varela, Giorgi Kuchukhidze, Wiebke Hahn, Clara Jünemann, Lukas Machegger, Leona Möller, Johannes Pfaff, Eugen Trinka, Susanne Knake, Panagiota‐Eleni Tsalouchidou   +9 more
wiley   +1 more source