Results 91 to 100 of about 4,126 (156)

Safety and immunogenicity of the M72/AS01 candidate tuberculosis vaccine in HIV-infected adults on combination antiretroviral therapy: a phase I/II, randomized trial.

, 2014
OBJECTIVE: Tuberculosis (TB) is highly prevalent among HIV-infected people, including those receiving combination antiretroviral therapy (cART), necessitating a well tolerated and efficacious TB vaccine for these populations.
Cohen, J., Ejigu, D., Mettens, P., Ofori-Anyinam, O., Spertini, F., Moris, P., Thacher, E.G., Bollaerts, A., Demoitié, M.A., Cavassini, M., Thierry, A.C., Audran, R., Thierry AC, Spertini F, Moris P, Ejigu D, Mettens P, Demoitié MA, Cavassini M, Cohen J, Thacher EG, Audran R, Bollaerts A, Ofori-Anyinam O   +23 more
core   +1 more source

Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine.

, 2012
RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum, is undergoing clinical trials. We report an analysis of cellular immune response to component Ags of RTS,S-hepatitis B surface Ag (HBs) and P.
Drakeley, Chris J, Riley, Eleanor M, King, Elizabeth, Horowitz, Amir, Hafalla, Julius CR, Corran, Patrick H, Moris, Philippe, Leach, Amanda, Vekemans, Johan, Cohen, Joe, Bejon, Philip, von Seidlein, Lorenz, Lusingu, John, Dekker, Denise, Villafana, Tonya   +14 more
core   +1 more source

Functional and epigenetic changes in monocytes from adults immunized with an AS01-adjuvanted vaccine

The adjuvant AS01 plays a key role in the immunogenicity of several approved human vaccines with demonstrated high efficacy. Its adjuvant effect relies on activation of the innate immune system.
Willems, Fabienne, van der Most, Robbert, Delandre, Simon, Bechtold, Viviane, Smolen, Kinga K., Didierlaurent, Arnaud, Burny, Wivine, Marchant, Arnaud, Ndour, Cheikh, Taton, Martin, de Angelis, Simone P., Essaghir, Ahmed   +11 more
core   +1 more source

RTS,S/AS01, a vaccine targeting pre-erythrocytic stages of Plasmodium falciparum

, 2017
RTS,S/AS01 is the most advanced vaccine to prevent malaria. It is safe and moderately effective. A large pivotal phase III trial in over 15 000 young children in sub-Saharan Africa completed in 2014 showed that the vaccine could protect around one-third ...
Sasithon Pukrittayakamee, Lorenz von Seidlein, Borimas Hanboonkunupakarn, Podjanee Jittmala   +3 more
core   +1 more source

Kinetics of Humoral immune responses against the F4 fusion protein.

, 2015
Anti-F4 IgG antibody concentrations measured by ELISA expressed as geometric mean concentration (GMC) in mEU/ml across groups A-D. Group A = 2xF4/AS01E / Ad35-GRIN, B = 2xF4/AS01B / Ad35-GRIN, C = Ad35-GRIN / 2xF4/AS01B and D = 3xCo-Ad. M = months.
William Kilembe (117352), Peter Hayes (10433), Gerald Voss (263502), Elwyn Chomba (221686), Juliet Mpendo (522761), Kristen Syvertsen (737112), Dagna Laufer (652370), Marguerite Koutsoukos (296151), Devika Zachariah (145161), Lorna Clark (145131), Eddy Sayeed (132289), Josephine Cox (10453), Frances Priddy (244455), Patricia Bourguignon (737110), Kamaal Anas (737113), Jill Gilmour (10465), Gwynn Stevens (62300), Burc Barin (145167), François Roman (80727), Eugene Ruzagira (285207), Patricia Fast (145172), Len Dally (62295), Jim Ackland (459775), Emmanuel Cormier (145169), Angela Lombardo (254189), Gloria Omosa-Manyonyi (241541), Alix Collard (737111)   +26 more
core   +1 more source

Establishing RTS,S/AS01 as a benchmark for comparison to next-generation malaria vaccines in a mouse model

npj Vaccines
New strategies are needed to reduce the incidence of malaria, and promising approaches include vaccines targeting the circumsporozoite protein (CSP). To improve upon the malaria vaccine, RTS,S/AS01, it is essential to standardize preclinical assays to ...
Emily Locke, Yevel Flores-Garcia, Bryan T. Mayer, Randall S. MacGill, Bhavesh Borate, Berenice Salgado-Jimenez, Monica W. Gerber, Shamika Mathis-Torres, Sarah Shapiro, C. Richter King, Fidel Zavala   +10 more
doaj   +1 more source

Safety of the M72/AS01 Tuberculosis Vaccine in People Living With HIV: A Systematic Review and Meta-Analysis. [PDF]

Open Forum Infect Dis
Pereira PS, Neri Junior JCS, Oliveira-De-Souza D, Andrade BB, Barreto-Duarte B.   +4 more
europepmc   +1 more source

Dataset on water quality and trophic status assessment of San Martín Lake (Ecuador) using NSF, OWQI, CCME, OECD, Carlson and TRIX approaches (2021-2022). [PDF]

Data Brief
Garcia-Avila F, Loja-Suco P, Siguenza-Jetón C, Tonon-Ordoñez MD, Guanuchi-Quito A, Zhindón-Arévalo C, Uguña-Rosas MF, Valdiviezo-Gonzales L.   +7 more
europepmc   +1 more source

Status of Malaria Vaccine Introduction-Africa, 2019-2024. [PDF]

Am J Trop Med Hyg
Ly AN, Walldorf JA, Hamel MJ, Pellaux-Furrer E, Okine RNA, Magafu MGMD, Patel JC, Hyde TB.   +7 more
europepmc   +1 more source

Safety and immunogenicity of the RTS,S/AS01 malaria vaccine in infants and children identified as HIV-infected during a randomized trial in sub-Saharan Africa

Background: We assessed the safety and immunogenicity of the RTS,S/AS01 malaria vaccine in a subset of children identified as HIV-infected during a large phase III randomized controlled trial conducted in seven sub-Saharan African countries.
Masoud, Nahya Salim, Sorgho, Hermann, Sacarlal, Jahit, Asante, Kwaku Poku, Aide, Pedro, Vandoolaeghe, Pascale, Owusu-Agyei, Seth, Otieno, Godfrey Allan, Agbenyega, Tsiri, Lanaspa, Miguel, Adjei, Samuel, Akoo, Pauline, Njuguna, Patricia, Guerra Mendoza, Yolanda, Mtoro, Ali Takadir, Malabeja, Anangisye, Gesase, Samwel, Kaali, Seyram, Tanner, Marcel, Kariuki, Simon, Agnandji, Selidji Todagbe, Kamthunzi, Portia, Oneko, Martina, Otieno, Lucas, Tinto, Halidou, Otieno, Walter, Schuerman, Lode, Kremsner, Simon, Valea, Innocent, Ansong, Daniel, Lell, Bertrand, Lievens, Marc, Ofori-Anyinam, Opokua, Hamel, Mary J., Berkley, James A., Lusingu, John, Hoffman, Irving   +36 more
core