Results 71 to 80 of about 4,126 (156)

From Mycosynthesis to Immunomodulation: Exploring the Safety, Adjuvant Potential and Microbiota Impact of Biogenic Silver Nanoparticles

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
Mycosynthesized silver nanoparticles from fungal strains act as safe, biocompatible vaccine adjuvants. They enhance immune responses in mice, promoting strong, dose‐dependent IgG2a polarization with minimal toxicity and limited gut microbiota disruption, highlighting their potential as versatile next‐generation platforms for subunit vaccine development.
Ana Clara Muniz‐Lagos, Diego M. Roldán, Paula Arbildi, Gustavo Mourglia‐Ettlin, Silvana Alborés   +4 more
wiley   +1 more source

A seven-year study on the effect of the pre-erythrocytic malaria vaccine candidate RTS,S/AS01E on blood stage immunity in young Kenyan children [version 1; peer review: 1 approved, 2 approved with reservations]

Wellcome Open Research, 2019
Background: RTS,S/AS01 E, the most advanced malaria vaccine confers partial immunity. The vaccine-induced pre-erythrocytic immunity reduces exposure to blood-stage parasites, delaying acquisition of antibodies to blood-stage antigens.
Francis M. Ndungu, Jedida Mwacharo, Juliana Wambua, Patricia Njuguna, Kevin Marsh, Chris Drakeley, Philip Bejon   +6 more
doaj   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Loss of qE Does Not Necessarily Lead to Photoinhibition: Sustained Non‐Photochemical Quenching in the Absence of PsbS and Zeaxanthin

Plant, Cell &Environment, Volume 49, Issue 6, Page 3405-3425, June 2026.
ABSTRACT Photosynthetic light‐harvesting complexes mediate light absorption and energy dissipation. By modulating the photosystems' absorption cross‐section, they affect both photosynthetic activity and non‐photochemical quenching (NPQ). These processes are often studied by spectrally integrated chlorophyll fluorescence, masking their associated ...
Maximiliano Cainzos, Chen Hu, Maria Dolores Pissolato, Nazeer Fataftah, Sanchali Nanda, Stefan Jansson   +5 more
wiley   +1 more source

Comparison of efficacy against infection for RTS,S/AS01 and RTS,S/AS02.

, 2013
Comparison of efficacy against infection as a function of anti-CSP antibody titre in the absence of CSP-specific CD4+ T cells for RTS,S/AS01 (black) and RTS,S/AS02 (pink) based on the sporozoite infection model. The grey and pink shaded regions denote 95%
Jamie T. Griffin (219983), Philip Bejon (40508), Ally Olotu (108545), Azra C. Ghani (160248), Kent E. Kester (261339), Michael T. White (402788), Eleanor M. Riley (25407), Christian F. Ockenhouse (201973)   +7 more
core   +1 more source

Immunopotentiation by Natural Extracts: Mechanisms and Applications in Influenza Vaccine Adjuvant Development

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Natural Extracts as Candidate Influenza Vaccine Adjuvants. Seasonal influenza vaccines face limitations due to viral mutations and low efficacy in vulnerable populations. Traditional adjuvants often have safety or immune‐activation constraints, leading to increased interest in natural extracts from plants, marine organisms, and fungi.
Thi Len Ho, Eun‐Ju Ko
wiley   +1 more source

Respiratory Syncytial Virus (RSV): A Comprehensive Overview From Basic Biology to Clinical Prevention and Control

Medicinal Research Reviews, Volume 46, Issue 3, Page 672-712, May 2026.
ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi, Xiya Huang, Chunjun Ye, Yishan Lu, Yanyan Liu, Yuquan Wei, Xiawei Wei   +6 more
wiley   +1 more source

Antibody gene features associated with binding and functional activity in malaria vaccine-derived human mAbs

npj Vaccines
The impact of adjuvants on malaria vaccine-induced antibody repertoire is poorly understood. Here, we characterize the impact of two adjuvants, Alhydrogel® and AS01, on antibody clonotype diversity, binding and function, post malaria vaccination.
Camila H. Coelho, Susanna Marquez, Bergeline C. Nguemwo Tentokam, Anne D. Berhe, Kazutoyo Miura, Vishal N. Rao, Carole A. Long, Ogobara K. Doumbo, Issaka Sagara, Sara Healy, Steven H. Kleinstein, Patrick E. Duffy   +11 more
doaj   +1 more source

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission

Small, Volume 22, Issue 28, 18 May 2026.
Engineered malaria antigens enable in vivo bioconjugation to submicron biopolymer particles in E. coli. Two antigens are co‐tethered at high density and defined stoichiometry. The resulting thermostable particles elicit strong, durable antibody and T‐cell responses, conferring robust protection and blocking mosquito transmission.
Nivethika Sivakumaran, Yevel Flores‐Garcia, Chanel M. Naar, Shuxiong Chen, Mili Mehta, Fijs W. B. van Leeuwen, Abhai Tripathi, Rajagopal Murugan, Meta Roestenberg, Fidel Zavala, Bernd H. A. Rehm   +10 more
wiley   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, Volume 15, Issue 14, 10 April 2026.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source