Results 21 to 30 of about 4,126 (156)

The Future of the RTS,S/AS01 Malaria Vaccine: An Alternative Development Plan. [PDF]

PLoS Medicine, 2016
Roly Gosling and Lorenz von Seidlein consider a potential future development plan for the RTS,S/AS01 malaria vaccine.
Roly Gosling, Lorenz von Seidlein
doaj   +3 more sources

Innate immune cell activation by adjuvant AS01 in human lymph node explants is age independent

The Journal of Clinical Investigation
Vaccine adjuvants are thought to work by stimulating innate immunity in the draining lymph node (LN), although this has not been proven in humans. To bridge the data obtained in animals to humans, we have developed an in situ human LN explant model to ...
Vicki V. Stylianou, Kirstie M. Bertram, Van Anh Vo, Elizabeth B. Dunn, Heeva Baharlou, Darcii J. Terre, James Elhindi, Elisabeth Elder, James French, Farid Meybodi, Stéphane T. Temmerman, Arnaud M. Didierlaurent, Margherita Coccia, Kerrie J. Sandgren, Anthony L. Cunningham   +14 more
doaj   +2 more sources

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age-Related Declines in Humoral and Cellular Immunity Relative to Shingrix. [PDF]

Adv Sci (Weinh)
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Song YE, Yan J, Ou BS, Saouaf OM, Eckman N, Appel EA.   +5 more
europepmc   +2 more sources

Quantitative and Clinical Pharmacology Perspectives on Next-Generation Malaria Prevention Using Vaccines and Long-Acting Monoclonal Antibodies. [PDF]

Clin Transl Sci
ABSTRACT Malaria remains a significant global health burden, particularly among pediatric populations in endemic regions. Recent advances in preventive interventions highlight the complementary roles of vaccines and long‐acting monoclonal antibodies (mAbs) in reducing infection risk.
Mim SR, Xavier LC, Azeredo FJ, Ait-Oudhia S.   +3 more
europepmc   +2 more sources

Immunogenicity and safety of the non-typable Haemophilus influenzae–Moraxella catarrhalis (NTHi-Mcat) vaccine administered following the recombinant zoster vaccine versus administration alone: Results from a randomized, phase 2a, non-inferiority trial

Human Vaccines & Immunotherapeutics, 2023
A candidate AS01-adjuvanted vaccine containing four surface proteins from non-typable Haemophilus influenzae and Moraxella catarrhalis (NTHi-Mcat) has been developed to help prevent exacerbations of chronic obstructive pulmonary disease (COPD ...
Ilaria Galgani, Airi Põder, Rain Jõgi, Veli-Jukka Anttila, Stefano Milleri, Alberto M. Borobia, Odile Launay, Marco Testa, Daniela Casula, Luca Grassano, Annaelisa Tasciotti, Marie Dozot, Ashwani K. Arora   +12 more
doaj   +1 more source

Similarities and differences of chemical compositions and physical and functional properties of adjuvant system 01 and army liposome formulation with QS21

Frontiers in Immunology, 2023
A vaccine adjuvant known as Adjuvant System 01 (AS01) consists of liposomes containing a mixture of natural congeners of monophosphoryl lipid A (MPL®) obtained from bacterial lipopolysaccharide, and a tree saponin known as QS21.
Carl R. Alving, Mangala Rao, Gary R. Matyas   +2 more
doaj   +1 more source

Long-term immunogenicity and safety of a non-typeable Haemophilus influenzae-Moraxella catarrhalis vaccine: 4-year follow-up of a phase 1 multicentre trial

Vaccine: X, 2021
A multicomponent vaccine has been developed to reduce the frequency of acute exacerbations of COPD associated with non-typeable Haemophilus influenzae (NTHi) and Moraxella catarrhalis (Mcat) infections, containing NTHi (PD and PE-PilA) and Mcat (UspA2 ...
Philippe De Smedt, Geert Leroux-Roels, Corinne Vandermeulen, Annaelisa Tasciotti, Gennaro Di Maro, Marie Dozot, Daniela Casula, Margherita Annaratone, Daniele Riccucci, Ashwani Kumar Arora   +9 more
doaj   +1 more source

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of March 2013 meeting [PDF]

, 2013
The Malaria Policy Advisory Committee to the World Health Organization met in Geneva, Switzerland from 13 to 15 March, 2013. This article provides a summary of the discussions, conclusions and recommendations from that meeting. Meeting sessions included:
Abdulla, Salim, Moorthy, Vasee, Valecha, Neena, D'Souza, Bianca, Lynch, Michael, Greenwood, Brian, Cibulskis, Richard, Ringwald, Pascal, Mnzava, Abraham, Olumese, Peter, Mendis, Kamini, Rietveld, Aafje, White, Nicholas, Graves, Patricia, Meek, Sylvia, Bosman, Andrea, Schapira, Allan, D'Acremont, Valerie, Newman, Robert, Malik, Elfatih, Tanner, Marcel, Alonso, Pedro, Leke, Rose, Binka, Fred, Slutsker, Laurence, Marsh, Kevin, null null, WHO Malaria Policy Advisory Committee and Secretariat,, WHO Malaria Policy Advisory Committee and Secretariat   +28 more
core   +3 more sources

Randomized controlled trial of RTS,S/AS02D and RTS,S/AS01E malaria candidate vaccines given according to different schedules in Ghanaian children. [PDF]

PLoS ONE, 2009
The target delivery channel of RTS,S candidate malaria vaccines in malaria-endemic countries in Africa is the World Health Organisation Expanded Program on Immunization.
Seth Owusu-Agyei, Daniel Ansong, Kwaku Asante, Sandra Kwarteng Owusu, Ruth Owusu, Naana Ayiwa Wireko Brobby, David Dosoo, Alex Osei Akoto, Kingsley Osei-Kwakye, Emmanuel Asafo Adjei, Kwadwo Owusu Boahen, Justice Sylverken, George Adjei, David Sambian, Stephen Apanga, Kingsley Kayan, Johan Vekemans, Opokua Ofori-Anyinam, Amanda Leach, Marc Lievens, Marie-Ange Demoitie, Marie-Claude Dubois, Joe Cohen, W Ripley Ballou, Barbara Savarese, Daniel Chandramohan, John Owusu Gyapong, Paul Milligan, Sampson Antwi, Tsiri Agbenyega, Brian Greenwood, Jennifer Evans   +31 more
doaj   +1 more source

Trained Immunity in Childhood Vaccination. [PDF]

Acta Paediatr
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
Cai C, Hossenbaccus L, Kaufmann E.
europepmc   +2 more sources