Results 41 to 50 of about 167,102 (249)

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Ascites

The Korean Journal of Gastroenterology, 2018
Ascites is the most common cause of decompensation in cirrhosis, and 5% to 10% of patients with compensated cirrhosis develop ascites each year. The main factor of ascites formation is renal sodium retention due to activation of the renin-angiotensin ...
Soung Won Jeong
doaj   +1 more source

Lipid‐Driven OLR1/FOXM1/FGF19 Axis Orchestrates Crosstalk in an Epithelial‐Fibroblast Positive Feedback Promoting Progesterone Resistance in Endometrial Cancer

Advanced Science, EarlyView.
It is revealed that a metabolic–stromal loop driven by oxLDL–OLR1–FOXM1–FGF19 signaling promotes progesterone resistance in endometrial cancer. OxLDL activates epithelial–fibroblast crosstalk, enhancing proliferation and hormonal insensitivity. Disruption of this circuit, especially with resveratrol, restores MPA sensitivity, highlighting a potential ...
Xingchen Li, Yue Qi, Yuman Wu, Xinyi Bi, Yiqin Wang, Jiaqi Wang, Jingyuan Wang, Lingpu Zhang, Haihua Xiao, Jianliu Wang   +9 more
wiley   +1 more source

Chronic recurrent biliary ascites: An unusual scenario [PDF]

Scripta Medica, 2014
Biliary ascites in adults occurs most often as a complication of biliary procedures - endoscopic, radiologic or operative, but can occur after trauma as well.
Kutty Geeta, Gupta Shweta, Sekosan Marin
doaj  

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

A Male Infant with Congenital Chylous Ascites Accompanied by Hypertension

Erciyes Medical Journal, 2020
Background: Congenital chylous ascites is a condition that arises from a disorder of the abdominal lymphatic system. Case Report: In this case study, a nine-month-old infant diagnosed with congenital chylous ascites in the newborn period presented with ...
Derya Altay, Ismail Dursun, Zübeyde Gündüz, Duran Arslan   +3 more
doaj   +1 more source

To study ultrasound and chest X-ray findings and their role in the diagnosis of dengue fever in children

Journal of Family Medicine and Primary Care, 2023
Introduction: Dengue fever is a fatal viral illness affecting almost all age groups and is seen in almost all tropical countries. Ultrasonography (USG) can be a useful tool for the assessment and diagnosis of dengue fever.
Mahaveer S. Lakra, Sagar A. Karotkar, Bhavana Lakhkar, Vaishali Dhawan, Ashwini Lakra   +4 more
doaj   +1 more source

scPER: A Rigorous Computational Approach to Determine Cellular Subtypes in Tumors Aligned With Cancer Phenotypes From Total RNA Sequencing

Advanced Science, EarlyView.
scPER presents an adversarial‐autoencoder framework that deconvolves bulk total RNA‐seq to quantify tumor‐microenvironment cell types and uncover phenotype‐linked subclusters. Across diverse benchmarks, scPER improves accuracy over existing tools.
Bingrui Li, Xiaobo Zhou, Raghu Kalluri
wiley   +1 more source

Ascites Index – an attempt to objectify the assessment of ascites

Journal of Ultrasonography, 2018
Introduction: Ascites is observed in cancer patients as well as in other non-neoplastic processes. In some patients, it may cause severe symptoms that can become directly life-threatening.
Piotr Szkodziak, Piotr Czuczwar, Krzysztof Pyra, Filip Szkodziak, Tomasz Paszkowski, Hugo Rio Tinto, Sławomir Woźniak   +6 more
doaj   +1 more source

Placing a lumen-apposing metal stent despite ascites: feasibility and safety

VideoGIE, 2020
Background and Aims: Placing a lumen-apposing metal stent (LAMS) through ascites carries serious risks, including death from leakage around the LAMS and failure to create a mature fistula between the 2 lumens.
Shayan Irani, MD
doaj   +1 more source