Results 51 to 60 of about 144,034 (267)

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Prognostic value of the ascites characteristics in pseudomyxoma peritonei originating from the appendix

Frontiers in Surgery, 2023
BackgroundPseudomyxoma peritonei (PMP) is a rare disease, with the overall survival (OS) influenced by many factors. To date, no ascites characteristics have been reported to predict OS of patients with PMP.
Bing Wang, Bing Wang, Xibo Sun, Ruiqing Ma, Zhenpeng Yang, Zhenpeng Yang, Huazhen Tang, Huazhen Tang, Shuai Lu, Shuai Lu, Jinxiu Qu, Jinxiu Qu, Yuying Wang, Yuying Wang, Benqiang Rao, Benqiang Rao, Hongbin Xu   +16 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Echocardiographic Findings in Cirrhotic Patients with and without Ascites Compared to Normal

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2010
BACKGROUND AND OBJECTIVE: Liver cirrhosis involves most organs and systems. Abnormalities in cardiac function have been reported in liver cirrhosis, suggesting a latent cardiomyopathy in these patients.
M Kashifard, M Saravi, H Taheri, R Bahreini   +3 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Development and validation of the Cirrhotic Ascites Severity model—A patient‐reported outcome‐based model to predict 1‐year mortality

Hepatology Communications, 2022
Ascites formation is a sign of decompensation of cirrhosis and heralds a poor prognosis. The widely used standard binary classification of ascites as diuretic‐responsive or refractory does not cover the spectrum of ascites and has limited prognostic ...
Rasmus Hvidbjerg Gantzel, Niels Kristian Aagaard, Hendrik Vilstrup, Hugh Watson, Henning Grønbæk, Peter Jepsen   +5 more
doaj   +1 more source

A Deep Residual U-Net Algorithm for Automatic Detection and Quantification of Ascites on Abdominopelvic Computed Tomography Images Acquired in the Emergency Department: Model Development and Validation

Journal of Medical Internet Research, 2022
BackgroundDetection and quantification of intra-abdominal free fluid (ie, ascites) on computed tomography (CT) images are essential processes for finding emergent or urgent conditions in patients.
Hoon Ko, Jimi Huh, Kyung Won Kim, Heewon Chung, Yousun Ko, Jai Keun Kim, Jei Hee Lee, Jinseok Lee   +7 more
doaj   +1 more source

Temporal Immune and Metabolic Shifts Drive the Anti‐Tumor Efficacy of Resiquimod‐Loaded Nanoparticles in Peritoneal Carcinomatosis

Advanced Healthcare Materials, EarlyView.
Peritoneal carcinomatosis is a hard‐to‐treat spread of abdominal cancers that often returns after therapy. Nanoparticles were developed to retain an immune‐boosting drug in the abdomen. When combined with chemotherapy in mice, this approach eliminated tumors in many cases and prevented recurrence, helping the immune system mount a stronger, longer ...
Vanessa Chan, Po‐Han Chao, XuXin Sun, Jun Han, Sarah MacPherson, Lucas J. Andrew, Noah Y. Brittain, Tien Do, Marcel B. Bally, Julian J. Lum, Shyh‐Dar Li   +10 more
wiley   +1 more source

When Ascites Is Not Ascites!

Cureus
Patients presenting with ascites should be properly evaluated to differentiate potential etiologies. Then, based on the evaluation, we can tailor more accurate treatment plans for patients. Cirrhosis is the most common cause, and others include cancer, heart failure, and, in our case, rarely a visceral artery rupture.
Yang, Mei, Fahel, Aboud, Pohlman, Thomas, Donepudi, Ravi, Zafar, Sajid   +4 more
openaire   +2 more sources