Results 51 to 60 of about 167,102 (249)

NIR Ratiometric Fluorescent Antibody‐Drug Conjugate for Metastatic Ovarian Cancer Theranostics and Treatment Response Monitoring

Advanced Science, EarlyView.
In vivo optical imaging enhances antibody‐drug conjugate (ADC) optimization by enabling real‐time monitoring of stimulus‐responsive drug behavior. We report n501‐CYMMAF, a ratiometric theranostic with strong target affinity and low‐dose efficacy for ovarian metastasis.
Cheng Li, Zezhong Yu, Tao Pu, Yanling Wu, Gang Wang, Youhua Xie, Tianlei Ying, Zhenlin Yang, Yibing Shi   +8 more
wiley   +1 more source

Amount of ascites impacts survival in patients with hepatocellular carcinoma undergoing transarterial chemoembolization advocating for volumetric assessment

Scientific Reports
Preliminary work has shown that portal hypertension plays a key role for the prognosis in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolization (TACE).
Lukas Müller, Daniel Bender, Simon J. Gairing, Friedrich Foerster, Arndt Weinmann, Jens Mittler, Fabian Stoehr, Moritz C. Halfmann, Aline Mähringer-Kunz, Peter R. Galle, Roman Kloeckner, Felix Hahn   +11 more
doaj   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

2017 Korean Association for the Study of the Liver (KASL) Clinical Practice Guidelines for Ascites and Related Complications: What Has Been Changed from the 2011 KASL Clinical Practice Guidelines?

The Korean Journal of Gastroenterology, 2018
Ascites is a common complication in patients with liver cirrhosis and is the most common cause of hospitalization in these patients. The development of ascites is associated with a poor prognosis in patients with liver cirrhosis with a higher mortality ...
Yeon Seok Seo
doaj   +1 more source

Combination of Ethoxybenzyl‐Diethylenetriamine Pentaacetic Acid‐Enhanced Magnetic Resonance Imaging and a Serum Biomarker Is Useful in the Diagnosis of Hepatic Sinusoidal Disorder After Chemotherapy Treatment

Annals of Gastroenterological Surgery, EarlyView.
ROC analyses of APRI score, EOB‐MRI, and a combination of EOB‐MRI and APRI score for blue liver. ABSTRACT Aim Sinusoidal obstruction syndrome (SOS), also known as “blue liver (BL),” is a common hepatic injury following oxaliplatin‐based chemotherapy in patients with colorectal liver metastases (CRLM).
Tomonari Shimagaki, Keishi Sugimachi, Takahiro Tomino, Takeshi Kurihara, Emi Onishi, Yutaro Shimomura, Kenji Shinozaki, Masaru Morita   +7 more
wiley   +1 more source

Chylous ascites caused by resection of a choledochal cyst

African Journal of Paediatric Surgery, 2012
Chylous ascites is a rare complication of abdominal surgery in children. Particularly, reports of postoperative chylous ascites are rare. This report describes the very rare case of a 10-month-old girl complicated by chylous ascites after resection of a ...
Tatsuzo Mizukami, Tadao Okada, Shohei Honda, Hisayuki Miyagi, Masashi Minato, Satoru Todo   +5 more
doaj   +1 more source

Proposal of Early Drain Exchange After Pancreatoduodenectomy From the View of Reducing Postoperative Pancreatic Fistula

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background To mitigate the progression of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy (PD), appropriate drain management is required, and exchanging drainage tubes is commonly performed. However, the optimal timing of the first drain exchange has not yet been determined.
Taihei Soma, Mihoko Yamada, Ryo Ashida, Katsuhisa Ohgi, Shimpei Otsuka, Yoshiyasu Kato, Teiichi Sugiura, Katsuhiko Uesaka   +7 more
wiley   +1 more source

Is ramucirumab and paclitaxel therapy beneficial for second-line treatment of metastatic gastric or junctional adenocarcinoma for patients with ascites? Analysis of RAINBOW phase 3 trial data

Cancer Management and Research, 2019
Kei Muro,1 Min-Hua Jen,2 Rebecca Cheng3 1Department of Clinical Oncology, Outpatient Treatment Center, Aichi Cancer Center Hospital, Nagoya, Japan; 2Eli Lilly and Company Ltd, Windlesham, Surrey, UK; 3Eli Lilly and Company, Taipei, Taiwan Purpose: Second-
Muro K, Jen MH, Cheng R
doaj  

Impact of Prophylactic Cefepime on Surgical Site Infection and Severe Morbidity in Patients Who Underwent Pancreaticoduodenectomy With Preoperative Biliary Drainage

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Although prophylactic broad‐spectrum antibiotics can reduce postoperative complications after pancreaticoduodenectomy (PD), the optimal regimen remains uncertain. This study evaluated the impact of prophylactic cefepime (CFPM) on surgical site infection (SSI) and severe morbidity after PD with preoperative biliary drainage.
Genki Watanabe, Akihiro Murata, Yu Kasamatsu, Atsushi Ishihara, Daisuke Nagashima, Tetsuzo Tashima, Shintaro Kodai, Akishige Kanazawa, Sadatoshi Shimizu   +8 more
wiley   +1 more source

Osteoprotegerin (OPG) protects ovarian cancer cells from TRAIL-induced apoptosis but does not contribute to malignant ascites-mediated attenuation of TRAIL-induced apoptosis

Journal of Ovarian Research, 2012
Background Resistance to apoptosis is a major problem in ovarian cancer and correlates with poor prognosis. Osteoprotegerin (OPG) is a secreted factor in malignant ascites and acts as a decoy receptor for receptor activator of NF-κB ligand (RANKL) and ...
Lane Denis, Matte Isabelle, Rancourt Claudine, Piché Alain   +3 more
doaj   +1 more source