Results 41 to 50 of about 16,508 (232)

Interobserver Reproducibility of Dna-Image-Cytometry in Ascus or Higher Cervical Cytology

Cellular Oncology, 2004
In the present study, the aim has been to investigate the interobserver reproducibility of DNA‐image‐cytometry (DNA‐ICM) applied to routine Pap smears classified as Atypical Squamous Cells of Undetermined Significance (ASCUS) or higher lesions (ASCUS ...
Vu Quoc Huy Nguyen, Hans Jürgen Grote, Natalia Pomjanski, Kristiane Knops, Alfred Böcking   +4 more
doaj   +1 more source

Prevalence of human papillomavirus genotypes in women with normal and abnormal cervical cytology in Iran [PDF]

, 2006
Introduction: HPV infection has a prime etiologic role in development and progression of cervical cancer, one of the most frequent forms of cancer among women in developing countries.
Dastan, J., Ensani, F., Ghaffari, S.R., Mohagheghi, M.A., Mollahajian, H., Moradi, A., Mousavi-Jarrahi, A., Ramezanzadeh, F., Sabokbar, T., Yarandi, F.   +9 more
core  

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

Advanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao, Yaxian Liao, Pengyun Li, Regina Stasser de Gonzalez, Xuankun Chen, Nicholas S. Nieto, Florence M. Brunel, Nick Cox, Joseph Stock, Matthew McHenry, Guangsen Fu, Penghsuan Huang, Wenxin Wu, Deqin Cai, Lingjun Li, Alexander N. Zaykov, Weiping Tang   +16 more
wiley   +1 more source

Types of Human Papillomavirus (HPV) in Patients with ASCUS Pap Smear

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2022
Background and Objective: Human papillomavirus (HPV) is one of the common infectious and pathogenic agents, and some of its genotypes have the ability to cause malignant changes in the surface of mucous cells.
H Hassani, M Javadian, M Raanaei, A Abedi, Sh Yazdani   +4 more
doaj  

Resultados histológicos e detecção do HPV em mulheres com células escamosas atípicas de significado indeterminado e lesão escamosa intra-epitelial de baixo grau na colpocitologia oncológica Histological results and HPV detection in women with pap smear showing atypical squamous cells of undetermined significance and low-grade squamous intraepithelial lesion

Revista Brasileira de Ginecologia e Obstetrícia, 2004
OBJETIVOS: avaliar o desempenho da colpocitologia oncológica (CO) e da Captura de Híbridos II (CHII) para o diagnóstico de lesão cervical histológica significativa (NIC2/3) em mulheres encaminhadas com CO contendo atipias celulares de significado ...
André Luis Ferreira Santos, Sophie Françoise Mauricette Derchain, Luis Otávio Sarian, Elizabete Aparecida Campos, Marcos Roberto dos Santos, Gislaine Aparecida Fonsechi-Carvasan   +5 more
doaj   +1 more source

Does lowering the screening age for cervical cancer in The Netherlands make sense?\ud [PDF]

, 2008
Recommendations for the age to initiate cervical cancer screening should be directed towards maximum detection of early cervical cancer. However, the screening programme should do more good than harm. The aim of this analysis was to determine whether the
Anttila, Anttila, Arbyn, Arbyn, Arbyn, Barnabas, Bulk, Castle, de Graaf, de Sanjose, Engberts, Franco, Franco, Gustafsson, Haverkos, Jacobs, Kahn, Kyrgiou, Lahelma, Laukkanen, Loos, Miller, Mount, National Cancer Institute, Ostor, Raffle, Rebolj, Rebolj, Rogstad, Sigurdsson, Sigurdsson, Sinclair, Tacken, van Ballegooijen, van Ballegooijen, van Ballegooijen, Walboomers, Webb, Wilson   +38 more
core   +2 more sources

Decoding the Mechanism of Action of a Parasite TGFβ Antagonist Inspires the Creation of Cell‐Type‐Specific TGFβ Modulators

Advanced Science, EarlyView.
The mammalian TGFβ interacts with ubiquitously expressed TGFBR1 and TGFBR2, and current TGFβ‐targeting agents are non‐cell‐selective. The cooperative interaction of the modular parasite TGFβ antagonist with multiple host (co‐)receptors empowers the design of TGM chimeras and bispecific antibodies that activate or inhibit TGFβ signaling in a cell ...
Maarten van Dinther, Tristin Schwartze, Jiying Zhang, Kun Fan, Gerard van der Zon, Luke Power, Cynthia S. Hinck, Claire Ciancia, Ananya Mukundan, Roman Gonzalez‐Prieto, Peter van Veelen, Rick M. Maizels, Andrew P. Hinck, Peter ten Dijke   +13 more
wiley   +1 more source

Association of human papillomavirus with other coinfections prevailing in abnormal cervical lesions

Journal of Radiation and Cancer Research, 2021
Purpose: Human papillomavirus (HPV) is a common and necessary cause for cervical cancer development. However, association of other microbial infections such as bacterial vaginosis (BV), trichomonas vaginalis (TV), and hepatitis B virus (HBV) with HPV in ...
Gangotree Mohanty, Partha Singha, Chhanda Datta, Sankhadeep Dutta, Chinmay Kumar Panda   +4 more
doaj   +1 more source

Evaluation of the Methods Employed by the National Program of Uterine Cervical Cancer Control of the Brazilian Health Ministry [PDF]

, 2001
Purpose: to evaluate a populational sample of the screening proposed by the National Program of Uterine Cervical Cancer Control (PNCC), regarding the following issues: frequency of unsatisfactory cytologic results, cytologic frequency of atypical ...
Baracat, Edmund Chada, Focchi, José, Ribalta, Julisa Chamorro Lascasas, Roberto Neto, Alfredo   +3 more
core   +4 more sources

Chemotherapeutic Potential of Fluorouracil‐Platinum (IV) Prodrugs Against Cisplatin‐Resistant Colorectal Cancer Cells

Chemistry – A European Journal, EarlyView.
ABSTRACT Fluorouracil‐platinum(IV) prodrugs represent a novel class of multimechanistic chemotherapeutics with enhanced anticancer potential. The prodrugs PtIVP‐5FUMeOBut and PtIV56‐5FUMeOBut were actualized by derivatising the clinical drug 5‐fluorouracil (5FU) and coordinating it to platinum(IV) complexes, leveraging the established cytotoxicity of ...
Maria George Elias, Aleen Khoury, Shadma Fatima, Timothy J. Mann, Shawan Karan, Meena Mikhael, Paul de Souza, Christopher P. Gordon, Kieran F. Scott, Janice R. Aldrich‐Wright   +9 more
wiley   +1 more source