Results 51 to 60 of about 10,703 (258)

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

open access: yesAdvanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang   +12 more
wiley   +1 more source

HOMOIMPLANTE ORTOTÓPICO DE TENDÃO CALCÂNEO EM CÃES: CONSERVAÇÃO, ASSEPSIA E IMPLANTAÇÃO ORTHOTOPIC HOMOLOGOUS COMMON CALCANEOUS TENDON GRAFT IN DOGS: CONSERVATION, ASEPSIS AND IMPLANTATION

open access: yesCiência Rural, 2001
Foi elaborado um modelo experimental de conservação, assepsia e implantação de tendão homólogo ortotópico, para avaliar a resposta orgânica, em 48 cães. Os implantes foram conservados em glicerina a 98%, durante 45 dias a seis meses e, após, reidratados ...
Alceu Gaspar Raiser   +8 more
doaj   +1 more source

Pathogenicity of aseptic Bursaphelenchus xylophilus. [PDF]

open access: yesPLoS ONE, 2012
Pine wilt is a disease of pine (Pinus spp.) caused by the pine wood nematode (PWN), Bursaphelenchus xylophilus. However, the pathogenic mechanism of pine wilt disease (PWD) remains unclear.
Li-hua Zhu   +5 more
doaj   +1 more source

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

open access: yesAdvanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu   +18 more
wiley   +1 more source

A novel aseptic technique for micropropagation of Aloe vera mill [PDF]

open access: yesAdvanced Herbal Medicine, 2017
Background and aims:Aloe vera has been used medicinally for several thousands of years in many cultures from Egypt, Greece, and Rome to China, India, and etc. Although Aloe barbadensis propagates vegetative manner in its natural state, but propagation is
Zahra Abbasi
doaj  

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu   +10 more
wiley   +1 more source

Prevention of operative infection in ophthalmic surgery

open access: yesJournal of Clinical Ophthalmology and Research, 2016
Prevention of infection in ocular surgery is based on the science of asepsis and antisepsis not only depends on what we do pre-, intra-, and post-operatively but also depends on how we prepare our patient and personnel.
Uday R Gajiwala   +2 more
doaj   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

open access: yesAdvanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin   +16 more
wiley   +1 more source

A Millimeter‐Scale Implantable Magneto–Mechano–Electric Transducer Based on BTO Piezoelectric Ceramics for Remote Wireless Electrical Stimulation of Injured Sciatic Nerves

open access: yesAdvanced Science, EarlyView.
We report a fully wireless, circuit‐free neural stimulator built on a millimetric magneto‐mechano‐electric (MME) cantilever transducer (3 × 10 × 5 mm) with a barium titanate (BTO) piezoelectric ceramic core. Under low‐frequency alternating magnetic fields, the MME cantilever mechanically oscillates, inducing stress on the BTO element and thereby ...
Yijing Wang   +7 more
wiley   +1 more source

Prevention of postoperative infections in ophthalmic surgery

open access: yesIndian Journal of Ophthalmology, 2001
Postoperative endophthalmitis is a serious, vision-threatening complication of intraocular surgery. Better instrumentation, surgical techniques, prophylactic antibiotics and better understanding of asepsis have significantly reduced the incidence of this
Ram Jagat   +4 more
doaj  

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