Results 101 to 110 of about 1,183 (130)
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Expression of ASIC2 in ciliated cells and stereociliated cells
Cell and Tissue Research, 2008Acid-sensing ion channel 2 (ASIC2) plays a role as a mechanorecptor and acid receptor in the peripheral and central nervous systems. However, several recent studies have suggested that ASIC2 is expressed in several organs, in addition to the nervous system.
Shin Kikuchi +2 more
exaly +3 more sources
The Ion Channel ASIC2 Is Required for Baroreceptor and Autonomic Control of the Circulation [PDF]
Neuron, 2009 Arterial baroreceptors provide a neural sensory input that reflexly regulates the autonomic drive of circulation. Our goal was to test the hypothesis that a member of the acid-sensing ion channel (ASIC) subfamily of the DEG/ENaC superfamily is an important determinant of the arterial baroreceptor reflex. We found that aortic baroreceptor neurons in the
Xiuying Ma +2 more
exaly +3 more sources
ASIC2 Synergizes with TRPV1 in the Mechano-Electrical Transduction of Arterial Baroreceptors
Neuroscience Bulletin, 2021Mechanosensitive ion channels (MSCs) are key molecules in the mechano-electrical transduction of arterial baroreceptors. Among them, acid-sensing ion channel 2 (ASIC2) and transient receptor potential vanilloid subfamily member 1 (TRPV1) have been studied extensively and documented to play important roles.
Xiaodong, Yan +7 more
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Downregulation of mechanosensitive βENaC and γENaC in VSMCs in ASIC2 +/− mice
FASEB Journal, 2008 Previously, we evaluated the importance of the mechanosensitive protein ASIC2 in pressure‐induced constriction (PIC) in middle cerebral arteries in the ASIC2 mouse model. ASIC2 +/+ and −/− mice developed similar PIC (16 ± 2 and 10 ± 3%, respectively at 90 mm Hg). However, surprisingly, ASIC2 +/− mice developed less PIC (4 ± 2%).
Heather A Drummond
exaly +2 more sources
Impact of Reduced ASIC2 and Pregnancy on Seizure Susceptibility in Mice
The FASEB Journal, 2020Rationale Preeclampsia, a hypertensive disorder of pregnancy, can advance to eclampsia with the occurrence of new‐onset seizures in the mother. What induces this progression is unknown. Previous research found that utero‐placental ischemia, modeled by reducing uterine perfusion pressure (RUPP) in the rat ...
Maria Jones-Muhammad +3 more
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Bone marrow macrophage migration is dependent on ASIC2 and betaENaC
Physiology, 2023Monocyte-macrophages play an important role in phagocytosis of pathogens and cellular debris following infection or tissue injury in several pathophysiological conditions. Naïve macrophages (Mf), can be polarized into proinflammatory (M1), and/or anti-inflammatory (M2) phenotypes.
Heather Drummond +4 more
openaire +1 more source
Participation of the Chaperone Hsc70 in the Trafficking and Functional Expression of ASIC2 in Glioma Cells [PDF]
Journal of Biological Chemistry, 2007 High-grade glioma cells express subunits of the ENaC/Deg superfamily, including members of ASIC subfamily. Our previous work has shown that glioma cells exhibit a basally active cation current, which is not present in low-grade tumor cells or normal astrocytes, and that can be blocked by amiloride.
James K Bubien +2 more
exaly +3 more sources
ASIC2 Subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95 [PDF]
Journal of Neuroscience, 2009 Acid-sensing ion channel-1a (ASIC1a) mediates H(+)-gated current to influence normal brain physiology and impact several models of disease. Although ASIC2 subunits are widely expressed in brain and modulate ASIC1a current, their function remains poorly understood. We identified ASIC2a in dendrites, dendritic spines, and brain synaptosomes.
Xiang-Ming Zha +2 more
exaly +3 more sources