Results 1 to 10 of about 1,660 (170)
Regional and Subunit-Specific Downregulation of Acid-Sensing Ion Channels in the Pilocarpine Model of Epilepsy [PDF]
Neurobiology of Disease, 2001 Acid-sensing ion channels (ASICs) constitute a recently discovered family of excitatory cation channels, structurally related to the superfamily of degenerin/epithelial sodium channels. ASIC1b and ASIC3 are highly expressed in primary sensory neurons and
Giuseppe Biagini +4 more
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ppk23-Dependent chemosensory functions contribute to courtship behavior in Drosophila melanogaster. [PDF]
PLoS Genetics, 2012 Insects utilize diverse families of ion channels to respond to environmental cues and control mating, feeding, and the response to threats. Although degenerin/epithelial sodium channels (DEG/ENaC) represent one of the largest families of ion channels in ...
Beika Lu +4 more
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Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity [PDF]
Cell Reports, 2017 The homeostatic control of presynaptic neurotransmitter release stabilizes information transfer at synaptic connections in the nervous system of organisms ranging from insect to human. Presynaptic homeostatic signaling centers upon the regulated membrane
Brian O. Orr +5 more
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Identification of a novel protein complex containing ASIC1a and GABAA receptors and their interregulation. [PDF]
PLoS ONE, 2014 Acid-sensing ion channels (ASICs) belong to the family of the epithelial sodium channel/degenerin (ENaC/DEG) and are activated by extracellular protons. They are widely distributed within both the central and peripheral nervous systems.
Dongbo Zhao +6 more
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Frontiers in Physiology, 2020 Canonical epithelial sodium channels (ENaCs) are heterotrimers formed by α, β, and γ ENaC subunits in vertebrates and belong to the Degenerin/ENaC family of proteins. Proteins from this family form mechanosensitive channels throughout the animal kingdom.
Jan-Peter Baldin +3 more
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Frontiers in Oncology, 2022 Lung cancer is one of the most common cancer types in the world. Despite existing treatment strategies, overall patient survival remains low and new targeted therapies are required.
Anastasia V. Sudarikova +14 more
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Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography. [PDF]
PLoS ONE, 2018 Acid sensing ion channels (ASICs) are proton-gated ion channels that are members of the degenerin/epithelial sodium channel superfamily and are expressed throughout central and peripheral nervous systems.
Nate Yoder, Eric Gouaux
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Osmolarity-regulated swelling initiates egg activation in Drosophila
Open Biology, 2021 Egg activation is a series of highly coordinated processes that prepare the mature oocyte for embryogenesis. Typically associated with fertilization, egg activation results in many downstream outcomes, including the resumption of the meiotic cell cycle ...
Anna H. York-Andersen +4 more
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Frontiers in Pharmacology, 2019 Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are largely expressed in the mammalian nervous system. ASIC1a is highly permeable to Ca2+ and are involved in many physiological processes, including synaptic
D. Mango, R. Nisticò, R. Nisticò
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eLife, 2016 Genetic programming and neural activity drive synaptic remodeling in developing neural circuits, but the molecular components that link these pathways are poorly understood. Here we show that the C.
Tyne W Miller-Fleming +10 more
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