Is there a role of proinflammatory cytokines on degenerin‐mediated cerebrovascular function in preeclampsia? [PDF]
Physiological Reports, 2022 Preeclampsia (PE) is associated with adverse cerebrovascular effects during and following parturition including stroke, small vessel disease, and vascular dementia.
Zoltan Nemeth +3 more
doaj +4 more sources
The impact of Asic2 deletion on metabolic homeostasis in mice [PDF]
Physiological ReportsAcid‐Sensing Ion Channel 2 (Asic2) is expressed in many brain regions, including the hypothalamus, the homeostatic center for hunger‐satiety‐energy expenditure.
Madison Hamby +9 more
doaj +3 more sources
Physiological insight into the conserved properties of Caenorhabditis elegans acid‐sensing degenerin/epithelial sodium channels [PDF]
Journal of Physiology, 2023 Abstract figure legend Polar view of a phylogram of representative members of the DEG/ENaC superfamily, coloured according to phylum (Annelida, yellow; Arthropoda, light green; Chordata, dark green; Cnidaria, blue; Mollusca, dark purple; Nematoda, magenta; Placozoa, red). Construction of the phylogram is described in Fig. 1.
Eva Kaulich +2 more
exaly +5 more sources
Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization [PDF]
Physiological ReportsThe monocyte–macrophage system plays an important role in phagocytosis of pathogens and cellular debris following infection or tissue injury in several pathophysiological conditions.
Robert Wasson +4 more
doaj +3 more sources
ASIC currents in cultured primate retinal amacrine/ganglion cells [PDF]
Physiological ReportsAcid‐sensing ion channels (ASICs) are proton‐gated cation channels belonging to the epithelial Na + channel/degenerin superfamily. In the CNS, ASICs are involved in synaptic plasticity, learning/memory, and acidosis‐mediated injury.
Talib Saafir +4 more
doaj +3 more sources
Loss of βENaC Prevents Hepatic Steatosis but Promotes Abdominal Fat Deposition Associated with a High-Fat Diet [PDF]
BiologyBackground: Degenerin proteins, such as Acid-Sensing Ion Channel 2 (ASIC2) and β Epithelial Na+ Channel (βENaC), have been implicated in cardiovascular function.
Madison Hamby +3 more
doaj +2 more sources
Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome [PDF]
Frontiers in EndocrinologyIntroductionDegenerin proteins, such as βENaC and ASIC2, have been implicated in cardiovascular function. However, their role in metabolic syndrome have not been studied.
Madison Hamby +4 more
doaj +2 more sources
Degenerin/Epithelial Na+ Channel Proteins: Components of a Vascular Mechanosensor [PDF]
Hypertension, 2004 Mechanosensitive ion channels are thought to mediate stretch-induced contraction in vascular smooth muscle cells (VSMCs); however, the molecular identity of the mechanosensitive ion channel complex is unknown. Although recent reports suggest degenerin/epithelial Na + channel (DEG/ENaC) proteins may be mechanosensors
H. A. Drummond +2 more
core +4 more sources
Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution [PDF]
eLife, 2023 Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, the employment of specific LGICs ...
Josep Martí-Solans +4 more
doaj +2 more sources
bENaC is a molecular component of a VSMC mechanotransducer that contributes to renal blood flow regulation, protection from renal injury and hypertension. [PDF]
Frontiers in Physiology, 2012 Pressure-induced constriction (also known as the myogenic response) is an important mechanodependent response in certain blood vessels. The response is mediated by vascular smooth muscle cells (VSMCs) and characterized by a pressure-induced ...
Heather Anne Drummond
doaj +2 more sources