Results 31 to 40 of about 1,660 (170)

Functional analysis in a model sea anemone reveals phylogenetic complexity and a role in cnidocyte discharge of DEG/ENaC ion channels

Communications Biology, 2023
Phylogenetic analyses demonstrate a remarkable variety of the degenerin/epithelial Na+ channel (DEG/ENaC) superfamily in Cnidaria and discern an unexpected role for a proton-sensitive DEG/ENaC in N. vectensis cnidocyte discharge.
Jose Maria Aguilar-Camacho, Katharina Foreman, Adrian Jaimes-Becerra, Reuven Aharoni, Stefan Gründer, Yehu Moran   +5 more
doaj   +1 more source

Neuropeptides and degenerin/epithelial Na⁺ channels: a relationship from mammals to cnidarians

The Journal of Physiology, 2022
AbstractIon channels of the degenerin (DEG)/epithelial Na+ channel (ENaC) family serve diverse functions ranging from mechanosensation over Na+ reabsorption to H+ sensing and neurotransmission. However, several diverse DEG/ENaCs interact with neuropeptides; some are directly activated, whereas others are modulated by neuropeptides. Two questions arise:
Stefan Gründer, Audrey Ortega Ramírez, Gáspár Jékely   +2 more
openaire   +3 more sources

Factors and Molecular Mechanisms Influencing the Protein Synthesis, Degradation and Membrane Trafficking of ASIC1a

Frontiers in Cell and Developmental Biology, 2020
Acid-sensing ion channels (ASICs) are members of the degenerin/epithelial sodium channel superfamily. They are extracellular pH sensors that are activated by protons.
Yayun Xu, Yayun Xu, Yayun Xu, Feihu Chen, Feihu Chen, Feihu Chen   +5 more
doaj   +1 more source

Sensory experience controls dendritic structure and behavior by distinct pathways involving degenerins. [PDF]

Elife, 2018
Dendrites are crucial for receiving information into neurons. Sensory experience affects the structure of these tree-like neurites, which, it is assumed, modifies neuronal function, yet the evidence is scarce, and the mechanisms are unknown. To study whether sensory experience affects dendritic morphology, we use the
Inberg S, Iosilevskii Y, Calatayud-Sanchez A, Setty H, Oren-Suissa M, Krieg M, Podbilewicz B.   +6 more
europepmc   +5 more sources

The Potential Role of Calcium Channels in Pulmonary Hypertension. [PDF]

Biomed Res Int
Pulmonary hypertension (PH) is a severe cardiovascular syndrome characterized by progressively elevated pulmonary arterial pressure and driven pathologically by sustained vasoconstriction and irreversible vascular remodeling. Growing evidence underscores the central role of calcium ion (Ca2+) signaling networks in PH pathogenesis, which dynamically ...
Wu P, Zhong D, He X, Li Y, Zhang H.
europepmc   +2 more sources

The genome sequence of a spider mite, Tetranychus truncatus, provides insights into interspecific host range variation and the genetic basis of adaptation to a low‐quality host plant

Insect Science, Volume 30, Issue 5, Page 1208-1228, October 2023., 2023
The phytophagous mite Tetranychus truncatus is a significant pest in East Asia, but its host range is relatively narrower than that of Tetranychus urticae, another pest mite. We have produced a high‐quality, chromosomal‐level genome of T. truncatus and compared it with that of T. urticae. Our findings indicate that T.
Lei Chen, Xin‐Yue Yu, Xiao‐Feng Xue, Feng Zhang, Li‐Xue Guo, Hua‐Meng Zhang, Ary A. Hoffmann, Xiao‐Yue Hong, Jing‐Tao Sun   +8 more
wiley   +1 more source

A Stomatin and a Degenerin Interact to Control Anesthetic Sensitivity in Caenorhabditis elegans [PDF]

Genetics, 1999
Abstract The mechanism of action of volatile anesthetics is unknown. In Caenorhabditis elegans, mutations in the gene unc-1 alter anesthetic sensitivity. The protein UNC-1 is a close homologue of the mammalian protein stomatin. Mammalian stomatin is thought to interact with an as-yet-unknown ion channel to control sodium flux. Using both
S, Rajaram, T L, Spangler, M M, Sedensky, P G, Morgan   +3 more
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2023/24: Ion channels

British Journal of Pharmacology, Volume 180, Issue S2, Page S145-S222, October 2023., 2023
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links
Stephen P. H. Alexander, Alistair A. Mathie, John A. Peters, Emma L. Veale, Jörg Striessnig, Eamonn Kelly, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Jamie A. Davies, Richard W. Aldrich, Bernard Attali, Austin M. Baggetta, Elvir Becirovic, Martin Biel, Roslyn M. Bill, Ana I. Caceres, William A. Catterall, Alex C. Conner, Paul Davies, Katrien De Clerq, Markus Delling, Francesco Di Virgilio, Simonetta Falzoni, Stefanie Fenske, Anna Fortuny‐Gomez, Samuel Fountain, Chandy George, Steve A. N. Goldstein, Christian Grimm, Stephan Grissmer, Kotdaji Ha, Verena Hammelmann, Israel Hanukoglu, Meiqin Hu, Ad P. Ijzerman, Sairam V. Jabba, Mike Jarvis, Anders A. Jensen, Sven E. Jordt, Leonard K. Kaczmarek, Stephan Kellenberger, Charles Kennedy, Brian King, Philip Kitchen, Qiang Liu, Joseph W. Lynch, Jessica Meades, Verena Mehlfeld, Annette Nicke, Stefan Offermanns, Edward Perez‐Reyes, Leigh D. Plant, Lachlan Rash, Dejian Ren, Mootaz M. Salman, Werner Sieghart, Lucia G. Sivilotti, Trevor G. Smart, Terrance P. Snutch, Jinbin Tian, James S. Trimmer, Charlotte Van den Eynde, Joris Vriens, Aguan D. Wei, Brenda T. Winn, Heike Wulff, Haoxing Xu, Fan Yang, Wei Fang, Lixia Yue, Xiaoli Zhang, Michael Zhu   +72 more
wiley   +1 more source

Restrictive expression of acid-sensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum. [PDF]

PLoS ONE, 2014
Acid-sensing ion channels (Asic) are ligand-gated ion channels in the Degenerin/Epithelial Na+ channel (Deg/ENaC) family. Asic proteins are richly expressed in mammalian neurons. Mammals express five Asic genes: Asic1-5.
Nina Boiko, Volodymyr Kucher, Bin Wang, James D Stockand   +3 more
doaj   +1 more source

Dynamic Stimulations with Bioengineered Extracellular Matrix‐Mimicking Hydrogels for Mechano Cell Reprogramming and Therapy

Advanced Science, Volume 10, Issue 21, July 27, 2023., 2023
Cells communicate with their surroundings through both static and dynamic mechanical signals, which vary over stimulus type, intensity, location, and duration. Current knowledge on dynamic mechanical stimulations is limited compared to static ones. For this, researchers are now developing extracellular matrix‐mimicking biofunctional hydrogels that can ...
Yufeng Shou, Xin Yong Teo, Kenny Zhuoran Wu, Bingyu Bai, Arun R. K. Kumar, Jessalyn Low, Zhicheng Le, Andy Tay   +7 more
wiley   +1 more source