Results 21 to 30 of about 1,660 (170)
Acid-Sensing Ion Channel 2: Function and Modulation [PDF]
Membranes, 2022 Acid-sensing ion channels (ASICs) have an important influence on human physiology and pathology. They are members of the degenerin/epithelial sodium channel family.
Andy Sivils +3 more
doaj +2 more sources
The Degenerin/ENaC channel, encoded by ACCN5, serves a critical function in the vestibulocerebellum [PDF]
The FASEB Journal, 2013 ACCN5 encodes the BLINaC/hINaC member of the Deg/ENaC ion channel family. As we demonstrate using a novel mouse line that we engineered to contain a LacZ cassette knockin that interrupts the third exon of this gene, BLINaC has a unique expression profile for a Deg/ENaC channel.
Volodymyr Kucher +2 more
core +2 more sources
Functional domains within the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels [PDF]
The Journal of Physiology, 1999 Application of recombinant DNA technology and electrophysiology to the study of amiloride‐sensitive Na+ channels has resulted in an enormous increase in the understanding of the structure‐function relationships of these channels. Moreover, this knowledge has permitted the elucidation of the physiological roles of these ion channels in cellular ...
Bruce A. Stanton, Dale J. Benos
core +4 more sources
The bile acid-sensitive ion channel is gated by Ca2+-dependent conformational changes in the transmembrane domain [PDF]
Nature CommunicationsThe bile acid-sensitive ion channel (BASIC) is the least understood member of the mammalian epithelial Na+ channel/degenerin (ENaC/DEG) superfamily of ion channels, which are involved in a variety of physiological processes.
Makayla M. Freitas, Eric Gouaux
doaj +2 more sources
The Journal of Physiology, 2004 Degenerins have emerged from genetic studies in Caenorhabditis elegans as candidate mechanically gated amiloride-sensitive ion channels for transducing mechanical stimuli into cellular responses. In C.
Segalat, L. +11 more
core +5 more sources
ASIC2b: Mammalian Degenerin 2 (MDEG2), Brain Sodium Channel 1 (BNaC1b) [PDF]
, 2013 core +2 more sources
The Role of Neuro-Immune Regulation in the Pathogenesis of Psoriasis. [PDF]
J Immunol ResPsoriasis is a chronic inflammatory skin disease characterized by abnormal proliferation of epidermal cells induced by an overactive immune system. In addition to the interaction between immune cells and keratinocytes, emerging research highlights the indispensable role of peripheral sensory neurons in the initiation and progression of psoriatic ...
Liu X +9 more
europepmc +2 more sources
Physiological insight into the conserved properties of Caenorhabditis elegans acid-sensing degenerin/epithelial sodium channels. [PDF]
, 2022 Acid-sensing ion channels (ASICs) are members of the diverse family of degenerin/epithelial sodium channels (DEG/ENaCs). They perform a wide range of physiological roles in healthy organisms, including in gut function and synaptic transmission, but also ...
core +2 more sources