Degenerin Sites Mediate Proton Activation of δβγ-Epithelial Sodium Channel [PDF]
Journal of Biological Chemistry, 2004 The δ-subunit of epithelial Na+ channels (ENaC) is predominately expressed in brain, heart, and pancreas. The amiloride sensitivity, Na+ conductance, and critical domains for gating are characterized as a cross between proton-activated Na+ channels and α-ENaC.
Hong-Long Ji, Dale J. Benos
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Natural antisense transcripts regulate the neuronal stress response and excitability
eLife, 2014 Neurons regulate ionic fluxes across their plasma membrane to maintain their excitable properties under varying environmental conditions. However, the mechanisms that regulate ion channels abundance remain poorly understood.
Xingguo Zheng +3 more
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The Drosophila gene CheB42a is a novel modifier of Deg/ENaC channel function. [PDF]
PLoS ONE, 2010 Degenerin/epithelial Na(+) channels (DEG/ENaC) represent a diverse family of voltage-insensitive cation channels whose functions include Na(+) transport across epithelia, mechanosensation, nociception, salt sensing, modification of neurotransmission, and
Yehuda Ben-Shahar +5 more
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Frontiers in Physiology, 2021 Acid-Sensing Ion Channels (ASICs) are proton-gated sodium-selective cation channels that have emerged as metabolic and pain sensors in peripheral sensory neurons and contribute to neurotransmission in the CNS.
Daniel S. Matasic +18 more
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, 2002 Members of the ENaC/degenerin family of ion channels include the epithelial sodium channel (ENaC), acid-sensing ion channels (ASICs) and the nematode Caenorhabditis elegans degenerins. These channels are activated by a variety of stimuli such as ligands (
Gautschi, I. +5 more
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MEC-2 Is Recruited to the Putative Mechanosensory Complex in C. elegans Touch Receptor Neurons through Its Stomatin-like Domain [PDF]
, 2004 Background: The response to gentle body touch in C. elegans requires a degenerin channel complex containing four proteins (MEC-2, MEC-4, MEC-6, and MEC-10).
Yao, C.Andrea +5 more
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Inhibition of Neuronal Degenerin/Epithelial Na+ Channels by the Multiple Sclerosis Drug 4-Aminopyridine [PDF]
Journal of Biological Chemistry, 2013 The voltage-gated K(+) (Kv) channel blocker 4-aminopyridine (4-AP) is used to target symptoms of the neuroinflammatory disease multiple sclerosis (MS). By blocking Kv channels, 4-AP facilitates action potential conduction and neurotransmitter release in presynaptic neurons, lessening the effects of demyelination.
Nina, Boiko +3 more
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Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium transport [PDF]
, 2011 Despite large changes in salt intake, the mammalian kidney is able to maintain the extracellular sodium concentration and osmolarity within very narrow margins, thereby controlling blood volume and blood pressure.
Person, E. +7 more
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DEG/ENaCs Lead by a Nose: Mechanotransduction in a Polymodal Sensory Neuron [PDF]
, 2011 Degenerin/epithelial sodium channels (DEG/ENaCs) are luminaries of gentle touch in Caenorhabditis elegans. In this issue of Neuron, Geffeney et al. demonstrate that eponymous DEG-1 channels carry mechanotransduction currents in a polymodal neuron, where ...
Aislyn M. Nelson +5 more
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Functional Degenerin-containing Chimeras Identify Residues Essential for Amiloride-sensitive Na- Channel Function [PDF]
Journal of Biological Chemistry, 1995 The highly selective, amiloride-sensitive Na+ channel is formed of three homologous subunits termed alpha, beta, and gamma. The three subunits exhibit similarities with Caenorhabditis elegans proteins called degenerins involved in sensory touch transduction and, when mutated, in neurodegeneration.
R, Waldmann, G, Champigny, M, Lazdunski
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