Cloning and functional expression of a novel degenerin‐like Na+ channel gene in mammals [PDF]
The Journal of Physiology, 1999 1. A degenerate polymerase chain reaction (PCR) homology screening procedure was applied to rat brain cDNA in order to identify novel genes belonging to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family of ion channels. A single gene was identified that encodes a protein related to but clearly different from the already cloned members ...
H, Sakai +4 more
openaire +2 more sources
The Molecular Basis of Touch Sensation As Modeled in Caenorhabditis elegans [PDF]
, 2004 This chapter contains sections titled: Introduction Features of the C. elegans Model System Mechanosensation Is a Major Mechanism by Which C. elegans Senses Its Environment Gentle Body Touch The Touch Receptor Neurons Ultrastructural Features of the ...
Monica Driscoll +3 more
core +1 more source
Drosophila nociceptors mediate larval aversion to dry surface environments utilizing both the painless TRP channel and the DEG/ENaC subunit, PPK1. [PDF]
PLoS ONE, 2012 A subset of sensory neurons embedded within the Drosophila larval body wall have been characterized as high-threshold polymodal nociceptors capable of responding to noxious heat and noxious mechanical stimulation.
Wayne A Johnson, Justin W Carder
doaj +1 more source
An ion channel of the degenerin/epithelial sodium channel superfamily controls the defecation rhythm in Caenorhabditis elegans [PDF]
Proceedings of the National Academy of Sciences, 1998 Ultradian rhythms are widespread phenomena found in various biological organisms. A typical example is the defecation behavior of the nematode Caenorhabditis elegans, which repeats at about 45-sec intervals.
M, Take-Uchi +5 more
openaire +2 more sources
Two Novel DEG/ENaC Channel Subunits Expressed in Glia Are Needed for Nose-Touch Sensitivity in Caenorhabditis elegans [PDF]
, 2013 Neuronal DEG/ENaC (degenerin and epithelial Na + channel) Na + channels have been implicated in touch sensation. For example, MEC-4 is expressed in touch neurons in Caenorhabditis elegans and mediates gentle-touch response.
Lu, Yun +6 more
core +1 more source
Insights into the Molecular Determinants of Proton Inhibition in an Acid-Inactivated Degenerins and Mammalian Epithelial Na+ Channel [PDF]
Biochemistry, 2009 Mammalian ASIC channels of the DEG/ENaC superfamily are gated by extracellular protons and function to mediate touch and pain sensitivity, learning and memory, and fear conditioning. The recently solved crystal structure of chicken ASIC1a and preliminary functional studies suggested that a highly negatively charged pocket in the extracellular domain of
Ying, Wang, Laura, Bianchi
openaire +2 more sources
The Concise Guide to PHARMACOLOGY 2025/26: Ion channels
British Journal of Pharmacology, Volume 182, Issue S1, Page S152-S241, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +86 more
wiley +1 more source
Role of ASIC1a in Normal and Pathological Synaptic Plasticity [PDF]
, 2020 Acid-sensing ion channels (ASICs), members of the degenerin/epithelial Na+ channel superfamily, are broadly distributed in the mammalian nervous system where they play important roles in a variety of physiological processes, including neurotransmission ...
Mango, Dalila +3 more
core +1 more source
Molecular modeling of mechanosensory ion channel structural and functional features.
PLoS ONE, 2010 The DEG/ENaC (Degenerin/Epithelial Sodium Channel) protein family comprises related ion channel subunits from all metazoans, including humans. Members of this protein family play roles in several important biological processes such as transduction of ...
Renate Gessmann +3 more
doaj +1 more source
TheDrosophilaPostsynaptic DEG/ENaC Channelppk29Contributes to Excitatory Neurotransmission [PDF]
, 2017 The protein family of degenerin/epithelial sodium channels (DEG/ENaCs) is composed of diverse animal-specific, non-voltage-gated ion channels that play important roles in regulating cationic gradients across epithelial barriers.
Alexis Hill +5 more
core +1 more source