Results 71 to 80 of about 1,660 (170)

Sodium channels and mammalian sensory mechanotransduction

Molecular Pain, 2012
Background Members of the degenerin/epithelial (DEG/ENaC) sodium channel family are mechanosensors in C elegans, and Nav1.7 and Nav1.8 voltage-gated sodium channel knockout mice have major deficits in mechanosensation. β and γENaC sodium channel subunits
Raouf Ramin, Rugiero Francois, Kiesewetter Hannes, Hatch Rachel, Hummler Edith, Nassar Mohammed A, Wang Fan, Wood John N   +7 more
doaj   +1 more source

Invertebrate Bile Acid‐Sensitive Ion Channels and Their Emergence in Bilateria

The FASEB Journal, Volume 39, Issue 8, 30 April 2025.
This graphical abstract presents the evolutionary distribution and functional characteristics of bile acid‐sensing ion channels (BASICs) across bilaterians. A phylogenetic tree illustrates the presence of BASICs in diverse groups, extending beyond previously established mammalian findings.
Josep Martí‐Solans, Aina Børve, Line Vevle, Andreas Hejnol, Timothy Lynagh   +4 more
wiley   +1 more source

Inhibition of ASIC1a reduces ferroptosis in rheumatoid arthritis articular chondrocytes via the p53/NRF2/SLC7A11 pathway

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
Schematic representation of the molecular mechanism of ferroptosis induced by ASIC1a in chondrocytes. ASIC1a mediates Ca2+ influx, activating the p53/NRF2/SLC7A11 pathway and Fe2+ accumulation, thereby inducing ferroptosis in chondrocytes. Abstract The activation of acid‐sensing ion channel 1a (ASIC1a) in response to extracellular acidification leads ...
Jie Tang, Wenqiang Liu, Zihan Li, Can Shen, Longbiao Zhang, Cheng Wang, Fengshuo Wang, Zhuoyan Zai, Xuewen Qian, Weirong Hu, Xiaoyue Zhang, Xiaoqing Peng, Yayun Xu, Feihu Chen   +13 more
wiley   +1 more source

Bile acids potentiate proton-activated currents in Xenopus laevis oocytes expressing human acid-sensing ion channel (ASIC1a) [PDF]

, 2017
Acid‐sensing ion channels (ASICs) are nonvoltage‐gated sodium channels transiently activated by extracellular protons and belong to the epithelial sodium channel (ENaC)/Degenerin (DEG) family of ion channels.
Ilyaskin, Alexandr V., Christoph Korbmacher, Haerteis, Silke, Korbmacher, Christoph, Diakov, Alexei, Alexei Diakov, Silke Haerteis, Alexandr V. Ilyaskin   +7 more
core   +2 more sources

Evolutionary origin of the nervous system from Ctenophora prospective

Evolution &Development, Volume 26, Issue 4, July 2024.
This review discusses the evolutionary origin of the nervous system in light of the latest findings in the neuroscience of Ctenophora, one of the most enigmatic and earliest diverging animal lineages. Abstract Nervous system is one of the key adaptations underlying the evolutionary success of the majority of animal groups. Ctenophores (or comb jellies)
Maria Y. Sachkova
wiley   +1 more source

Direct visualization of the trimeric structure of the ASIC1a channel, using AFM imaging. [PDF]

, 2008
There has been confusion about the subunit stoichiometry of the degenerin family of ion channels. Recently, a crystal structure of acid-sensing ion channel (ASIC) 1a revealed that it assembles as a trimer.
Carnally, S.M., Henderson, R.M., Barrera, N.P., Dev, H.S., Stewart, A.P., Van Bemmelen, M.X., Edwardson, J.M., Schild, L.   +7 more
core   +1 more source

Expression of AmphiNaC, a new member of the amiloride-sensitive sodium channel related to degenerins and epithelial sodium channels in amphioxus [PDF]

International Journal of Biological Sciences, 2006
Degenerins and amiloride-sensitive Na+ channels form a new family of cationic ion channels (DEG/NaC). DEG/NaC family emerged as common denominator within a metazoan mechanosensory apparatus. In this study, we characterized a new member of such family in amphioxus, Branchiostoma floridae.
CANDIANI, SIMONA, D. OLIVERI, M. PARODI, PESTARINO, MARIO   +3 more
openaire   +3 more sources

Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing

Journal of Biomedical Science, 2018
Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system
Yuan-Ren Cheng, Bo-Yang Jiang, Chih-Cheng Chen   +2 more
doaj   +1 more source

Bacterially produced metabolites protect C. elegans neurons from degeneration.

PLoS Biology, 2020
Caenorhabditis elegans and its cognate bacterial diet comprise a reliable, widespread model to study diet and microbiota effects on host physiology. Nonetheless, how diet influences the rate at which neurons die remains largely unknown.
Arles Urrutia, Víctor A García-Angulo, Andrés Fuentes, Mauricio Caneo, Marcela Legüe, Sebastián Urquiza, Scarlett E Delgado, Juan Ugalde, Paula Burdisso, Andrea Calixto   +9 more
doaj   +1 more source

The fallacy of functional nomenclature in the kingdom of biological multifunctionality: physiological and evolutionary considerations on ion channels

The Journal of Physiology, Volume 602, Issue 11, Page 2367-2381, 1 June 2024.
Abstract figure legend Different features underlying the multifunctional nature of ion channels. Abstract Living organisms are multiscale complex systems that have evolved high degrees of multifunctionality and redundancy in the structure–function relationship. A number of factors, only in part determined genetically, affect the jobs of proteins.
Luca Munaron, Giorgia Chinigò, Giorgia Scarpellino, Federico Alessandro Ruffinatti   +3 more
wiley   +1 more source