Epithelial Na+ Channel Regulation by Extracellular and Intracellular Factors [PDF]
, 2018 Epithelial Na+ channels (ENaCs) are members of the ENaC/degenerin family of ion channels that evolved to respond to extracellular factors. In addition to being expressed in the distal aspects of the nephron, where ENaCs couple the absorption of filtered
Thomas R. Kleyman +2 more
core +1 more source
BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels [PDF]
Proceedings of the National Academy of Sciences, 1997 The recently defined DEG/ENaC superfamily of sodium channels includes subunits of the amiloride-sensitive epithelial sodium channel (ENaC) of vertebrate colon, lung, kidney, and tongue, a molluscan FMRFamide-gated channel (FaNaC), and the nematode degenerins, which are suspected mechanosensory channels.
J, García-Añoveros +4 more
openaire +2 more sources
Experimental Physiology, Volume 109, Issue 1, Page 66-80, 1 January 2024.Abstract Although acid‐sensing ion channels (ASICs) are proton‐gated ion channels responsible for sensing tissue acidosis, accumulating evidence has shown that ASICs are also involved in neurosensory mechanotransduction. However, in contrast to Piezo ion channels, evidence of ASICs as mechanically gated ion channels has not been found using ...
Yi‐Chen Lin +3 more
wiley +1 more source
SCNN1, an Epithelial Cell Sodium Channel Gene in the Conserved Linkage Group on Mouse Chromosome 6 and Human Chromosome 12 [PDF]
, 1994 SCNN1, a gene encoding a nonvoltage-gated sodium channel, was detected using a rat colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse SCNN1 was
Meisler, M. H. +7 more
core +1 more source
Epithelial sodium channel inhibition by AMP-activated protein kinase in oocytes and polarized renal epithelial cells. [PDF]
, 2005 International audienceThe epithelial Na(+) channel (ENaC) regulates epithelial salt and water reabsorption, processes that require significant expenditure of cellular energy.
Grieser, Heather, J. +8 more
core +1 more source
Degenerin/Epithelial Sodium Channels (DEG/ENaCs) Required for Mechanical Nociception Responses in
, 2014 Drosophila larvae respond to potentially tissue-damaging stimuli with nocifensive escape locomotion (NEL). NEL is a stereotyped withdrawal behavior in which the larva rotates along its long-body axis in a "corkscrew" pattern distinct from normal ...
Mauthner, Stephanie
core
Conditional gene targeting of the ENaC subunit genes Scnn1b and Scnn1g. [PDF]
, 2009 Epithelial sodium channels (ENaC) are members of the degenerin/ENaC superfamily of non-voltage-gated, highly amiloride-sensitive cation channels that are composed of three subunits (alpha-, beta-, and gamma-ENaC).
Charles, R.P. +6 more
core +1 more source
A nonconventional look at ionic fluxes in the skin: lessons from genetically modified mice [PDF]
, 2004 The mammalian, highly amiloride-sensitive epithelial sodium channel (ENaC) is member of the degenerin/ENaC superfamily of ion channels known to be implicated in sodium homeostasis, mechanosensation, and mechanoperception. A novel role for ENaC implicated
Hummler, E., Guitard, M., Leyvraz, C.
core
Amplification of Drosophila Olfactory Responses by a DEG/ENaC Channel [PDF]
, 2019 Insect olfactory receptors operate as ligand-gated ion channels that directly transduce odor stimuli into electrical signals. However, in the absence of any known intermediate transduction steps, it remains unclear whether and how these ionotropic inputs
Shepherd, Andrew K +8 more
core +1 more source
Acid-Sensing Ion Channels Contribute to the Effect of Acidosis on the Function of Dendritic Cells [PDF]
, 2011 As an H+-gated subgroup of the degenerin/epithelial Na+ channel family, acid-sensing ion channels (ASICs) were reported to be involved in various physiological and pathological processes in neurons. However, little is known about the role of ASICs in the
Xiaoling Kong +10 more
core +1 more source