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American Journal of Physiology-Renal Physiology, 2022
Transmission of systemic blood pressure to delicate renal microvessels is a primary determinant of vascular injury in chronic kidney disease progression to end-stage renal disease. Here, we identified two degenerin family members, with an evolutionary link to mechanosensing, that interact biochemically and functionally to regulate systemic blood ...
Yan Lu +4 more
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Transmission of systemic blood pressure to delicate renal microvessels is a primary determinant of vascular injury in chronic kidney disease progression to end-stage renal disease. Here, we identified two degenerin family members, with an evolutionary link to mechanosensing, that interact biochemically and functionally to regulate systemic blood ...
Yan Lu +4 more
openaire +2 more sources
Acid-sensing ion channel 2 (ASIC2) in the intestine of adult zebrafish
Neuroscience Letters, 2011Acid-sensing ion channels (ASICs) in mammals monitor acid sensing and mechanoreception. They have a widespread expression in the central and peripheral nervous system, including the gut. The distribution of ASICs in zebrafish is known only in larvae and at the mRNA level.
Maria Cristina Guerrera +2 more
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American Journal of Physiology - Renal Physiology, 2015 Previous studies from our laboratory have suggested that degenerin proteins contribute to myogenic constriction, a mechanism of blood flow regulation and protection against pressure-dependent organ injury, in renal vessels. The goal of the present study was to determine the importance of one family member, acid-sensing ion channel 2 (ASIC2), in ...
David E Stec, Heather A Drummond
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Histochemistry and Cell Biology, 2014
Mechanosensory neurons lead to the central nervous system touch, vibration and pressure sensation. They project to the periphery and form different kinds of mechanoreceptors. The manner in which they sense mechanical signals is still not fully understood, but electrophysiological experiments have suggested that this may occur through the activation of ...
R, Cabo +8 more
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Mechanosensory neurons lead to the central nervous system touch, vibration and pressure sensation. They project to the periphery and form different kinds of mechanoreceptors. The manner in which they sense mechanical signals is still not fully understood, but electrophysiological experiments have suggested that this may occur through the activation of ...
R, Cabo +8 more
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Hsc70 regulates cell surface ASIC2 expression and vascular smooth muscle cell migration
American Journal of Physiology - Heart and Circulatory Physiology, 2008Recent studies suggest members of the degenerin (DEG)/epithelial Na+channel (ENaC)/acid-sensing ion channel (ASIC) protein family play an important role in vascular smooth muscle cell (VSMC) migration. In a previous investigation, we found suppression of a certain DEG/ENaC/ASIC member, ASIC2, increased VSMC chemotactic migration, raising the ...
Heather A Drummond
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The FASEB Journal, 2007
Gliomas are primary brain tumors with a complex biology and a propensity for invasion into normal brain tissue. High‐grade glioma cells possess an amiloride sensitive current. This current is not seen in normal astrocytes or low‐grade tumor cells.
Wanda Helena Vila‐Carriles +2 more
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Gliomas are primary brain tumors with a complex biology and a propensity for invasion into normal brain tissue. High‐grade glioma cells possess an amiloride sensitive current. This current is not seen in normal astrocytes or low‐grade tumor cells.
Wanda Helena Vila‐Carriles +2 more
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Impaired pressure-induced constriction in mouse middle cerebral arteries of ASIC2 knockout mice
American Journal of Physiology - Heart and Circulatory Physiology, 2008Recent studies from our laboratory demonstrated the importance of mechanosensitive epithelial Na+channel (ENaC) proteins in pressure-induced constriction in renal and cerebral arteries. ENaC proteins are closely related to acid-sensing ion channel 2 (ASIC2), a protein known to be required for normal mechanotransduction in certain sensory neurons ...
Nikki L Jernigan, Heather A Drummond
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Investigating the potential regulation of Asic2 by microRNAs [PDF]
, 2012 Multiple Sclerosis (MS) is an inflammatory disease which causes neurodegeneration. It is a disease which affects mainly young adults, and symptoms become more aggressive over time. It is thought that mutations in a variety of genes may be a large contributor to the development of MS.
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Reductions in βENaC and ASIC2 Induce Preeclampsia‐Like Symptoms in Pregnant Mice
The FASEB Journal, 2016Preeclampsia is a complex, multi‐organ, pregnancy‐specific condition characterized by new onset hypertension with or without proteinuria past the 20 th week of gestation. The underlying pathophysiological mechanisms have not been fully elucidated. Beta Epithelial Na +
Junie Paula Warrington +3 more
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Investigating the role of ASIC2 subunits in synaptic and behavioral responses to drugs of abuse
Drugs of abuse produce rearrangements at glutamatergic synapses thought to contribute to drug-reinforced behaviors. Acid-Sensing Ion Channels (ASICs) have been suggested to oppose these effects, largely due to observations in mice lacking the ASIC1A subunit.openaire +1 more source