ASK1 signalling regulates brown and beige adipocyte function [PDF]
Nature Communications, 2016 The protein kinase ASK1 has been linked to cellular stress responses. Here the authors show that ASK1 also regulates gene expression and activity of beige and brown adipocytes, and demonstrate adipocyte ASK1 has a physiological role in regulating ...
Kazuki Hattori +2 more
exaly +4 more sources
Scientific Reports, 2021 Recent studies have shown that adipose tissue is an immunological organ. While inflammation in energy-storing white adipose tissues has been the focus of intense research, the regulatory mechanisms of inflammation in heat-producing brown adipose tissues ...
Saki Takayanagi +12 more
doaj +2 more sources
The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1 [PDF]
eLifeApoptosis signal-regulating kinase 1 (ASK1) is a crucial stress sensor, directing cells toward apoptosis, differentiation, and senescence via the p38 and JNK signaling pathways.
Karolina Honzejkova +3 more
doaj +2 more sources
TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1 [PDF]
Cell Reports, 2017 Apoptosis signal-regulating kinase 1 (ASK1) is an oxidative stress-responsive kinase that is regulated by various interacting molecules and post-translational modifications.
Yusuke Hirata +14 more
doaj +3 more sources
Ablation of the proapoptotic genes CHOP or Ask1 does not prevent or delay loss of visual function in a P23H transgenic mouse model of retinitis pigmentosa. [PDF]
PLoS ONE, 2014 The P23H mutation in rhodopsin (Rho(P23H)) is a prevalent cause of autosomal dominant retinitis pigmentosa. We examined the role of the ER stress proteins, Chop and Ask1, in regulating the death of rod photoreceptors in a mouse line harboring the Rho ...
Adeseye Adekeye +3 more
doaj +3 more sources
Knockdown of MiR-20a Enhances Sensitivity of Colorectal Cancer Cells to Cisplatin by Increasing ASK1 Expression [PDF]
Cellular Physiology and Biochemistry, 2018 Background/Aims: Platinum-based chemotherapy is one of the most important strategies for treatment of colorectal cancer. To improve the therapeutic efficiency, adjuvant drugs were sought to sensitize colorectal cancer cells to platinum-based agents such ...
Luyao Zhang +3 more
doaj +2 more sources
Oxidative Stress-Induced Diseases via the ASK1 Signaling Pathway [PDF]
International Journal of Cell Biology, 2012 Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase (MAPK) kinase kinase that activates the downstream MAPKs, c-Jun N-terminal kinase (JNK) and p38.
Mayumi Soga +2 more
doaj +2 more sources
Pathophysiological Roles of ASK1-MAP Kinase Signaling Pathways [PDF]
BMB Reports, 2007 Apoptosis signal-regulating kinase 1 (ASK1) is a mitogenactivated protein kinase (MAPK) kinase kinase that activates JNK and p38 kinases. ASK1 is activated by various stresses, such as reactive oxygen species (ROS), endoplasmic reticulum (ER) stress, lipopolysaccharide (LPS) and calcium influx which are thought to be responsible for the pathogenesis or
Hiroaki Nagai +3 more
openalex +4 more sources
ASK1 inhibition shows potential in DKD [PDF]
Nature Reviews Nephrology, 2018 Rebecca Kelsey
openalex +3 more sources
HPV16 E7 inhibits HBD2 expression by down-regulation of ASK1-p38 MAPK pathway in cervical cancer [PDF]
Virology JournalBackground Recent researches indicated a down-regulation of Human beta-defensin2 (HBD2) expression in cervical cancer cells, but the mechanism and clinical significance is not clear yet.
Juanjuan Liao +9 more
doaj +2 more sources