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Advances in Biological Regulation, 2017
Neurodegenerative diseases (NDDs) such as glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD) are characterized by the progressive loss of neurons, causing irreversible damage to patients. Longer lifespans may be leading to an increase in the number of
Xiaoli, Guo +4 more
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Neurodegenerative diseases (NDDs) such as glaucoma, multiple sclerosis (MS), Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD) are characterized by the progressive loss of neurons, causing irreversible damage to patients. Longer lifespans may be leading to an increase in the number of
Xiaoli, Guo +4 more
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Pleiotropic properties of ASK1
Biochimica et Biophysica Acta (BBA) - General Subjects, 2017Apoptosis signal-regulating kinase 1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), has the potential to induce cellular apoptosis under various physiological conditions. It has long been suggested that ASK1 is highly sensitive to oxidative stress and contributes substantially to apoptosis. However, recent studies have
Chihiro, Sakauchi +3 more
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Discovery and development of ASK1 inhibitors
2020Aberrant activation of mitogen-activated protein kinases (MAPKs) like c-Jun N-terminal kinase (JNK) and p38 is an event involved in the pathophysiology of numerous human diseases. The apoptosis signal-regulating kinase 1 (ASK1) is an upstream target that gets activated only under pathological conditions and as such is a promising target for therapeutic
Reginald, Brys +4 more
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Structural aspects of protein kinase ASK1 regulation
Advances in Biological Regulation, 2017Apoptosis signal-regulating kinase 1 (ASK1, also known as MAP3K5), a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, activates the p38 mitogen-activated protein kinase and the c-Jun N-terminal kinase (JNK) signaling cascades in response to various stressors.
Tomas Obsil, Veronika Obsilova
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Evaluation of WO2012003387, Gilead's ASK1 inhibitors
Expert Opinion on Therapeutic Patents, 2012A small number of novel N-(triazolylthiazol-2-yl) and N-(triazolylthienyl) benzamide and picolinamide derivatives are claimed. The compounds are ASK1 kinase inhibitors among which some have nanomolar potency and are potentially useful in the treatment of a diverse range of conditions.
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Novel therapeutic strategies targeting ASK1 in NASH
Nature Reviews Gastroenterology & Hepatology, 2017Currently, no pharmacological therapies are approved for the treatment of NASH. A new study now identifies CASP8 and FADD-like apoptosis regulator (CFLAR) as a novel suppressor of NASH and its associated disorders in a process dependent on the activation of apoptosis signal-regulating kinase 1 (ASK1).
Susanne, Schuster, Ariel E, Feldstein
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ASK1 promotes inflammation in senescence and aging
2023AbstractCellular senescence is a stress-induced, permanent cell cycle arrest involved in tumor suppression and aging. Senescent cells secrete bioactive molecules such as pro-inflammatory cytokines and chemokines. This senescence-associated secretory phenotype (SASP) has been implicated in immune-mediated elimination of senescent cells and age ...
Takeru Odawara +2 more
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Targeting ASK1 in ER stress-related neurodegenerative diseases
Expert Opinion on Therapeutic Targets, 2009The accumulation of malfolded proteins in the endoplasmic reticulum (ER) induces ER stress, leading to the disturbance of ER function. To restore ER function and ER homeostasis, cells possess a highly specific ER quality control system termed the unfolded protein response (UPR), which increases the capacity of protein folding and reduces the amount of ...
Kengo, Homma +3 more
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ASK1 regulates influenza virus infection-induced apoptotic cell death
Biochemical and Biophysical Research Communications, 2003Apoptosis occurs in influenza virus (IV)-infected cells. There are a number of mechanisms for the regulation of apoptosis. However, the molecular mechanism of IV infection-induced apoptosis is still controversial. Apoptosis signal-regulating kinase1 (ASK1) is a ubiquitously expressed mitogen-activated protein kinase kinase kinase (MAPKKK) that ...
Shuichiro, Maruoka +9 more
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Mechanism of Oxidative Stress-Induced ASK1-Catalyzed MKK6 Phosphorylation
Biochemistry, 2010Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine kinase that responds to a plethora of stress-inducing signals. In turn, activation of ASK1 is associated with a number of human pathological conditions, including neurodegenerative disease, inflammation, and heart failure.
Emmanuel, Sturchler +3 more
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