Results 11 to 20 of about 10,661 (224)

Identification of novel ASK1 inhibitors using virtual screening

Bioorganic & Medicinal Chemistry, 2010
Apoptosis signal-regulating kinase 1 (ASK1, also called MAP3K5) is a mitogen-activated protein kinase kinase kinase (MAP3K) that plays important roles in stress-induced cell death and inflammation, and is expected as a new therapeutic target for cancer, cardiovascular diseases, and neurodegenerative diseases.
Masako Okamoto, Nae Saito, Hirotatsu Kojima, Takayoshi Okabe, Kohsuke Takeda, Hidenori Ichijo, Toshio Furuya, Tetsuo Nagano   +7 more
openalex   +3 more sources

Octreotide attenuates intestinal ischemia/reperfusion mischief in rats through modulation of Nrf2/PRX2/ASK1/JNK signaling pathway. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
El Sayed NF, Ragab D, Abdo W, Ghoneim ME.   +3 more
europepmc   +3 more sources

The beneficial role of plant based thymol in food packaging application: A comprehensive review

Applied Food Research, 2022
The improvement of food-borne and infectious diseases has expanded globally at an anomalous rate and is combined with developing social and economic issues.
Salini Sivaram, Harshitha Somanathan, Sivaniraji Mariappan Kumaresan, Meenakshi Sundaram Muthuraman   +3 more
doaj   +1 more source

ASK1-K716R reduces neuroinflammation and white matter injury via preserving blood–brain barrier integrity after traumatic brain injury

Journal of Neuroinflammation, 2023
Background Traumatic brain injury (TBI) is a significant worldwide public health concern that necessitates attention. Apoptosis signal-regulating kinase 1 (ASK1), a key player in various central nervous system (CNS) diseases, has garnered interest for ...
Shan Meng, Hui Cao, Yichen Huang, Ziyu Shi, Jiaying Li, Yana Wang, Yue Zhang, Shuning Chen, Hong Shi, Yanqin Gao   +9 more
doaj   +1 more source

Functional cooperation between ASK1 and p21Waf1/Cip1 in the balance of cell-cycle arrest, cell death and tumorigenesis of stressed keratinocytes

Cell Death Discovery, 2021
Both CDKN1A (p21 Waf1/Cip1) and Apoptosis signal-regulating kinase 1 (ASK1) play important roles in tumorigenesis. The role of p21 Waf1/Cip1 in attenuating ASK1-induced apoptosis by various stress conditions is well established. However, how ASK1 and p21
Carlo De Blasio, Nagendra Verma, Marta Moretti, Samantha Cialfi, Azzurra Zonfrilli, Matteo Franchitto, Federica Truglio, Enrico De Smaele, Hidenori Ichijo, Isao Naguro, Isabella Screpanti, Claudio Talora   +11 more
doaj   +1 more source

Hsp90–Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis [PDF]

Oncogene, 2005
Hsp90 client protein Akt has been shown to inhibit cell apoptosis in part by inhibiting proapoptotic kinase ASK1 (apoptosis signal-regulating kinase 1) activity. In the present study, we show that Hsp90 inhibits hydrogen peroxide (H(2)O(2))-induced ASK1-p38 activation in endothelial cells (EC).
Rong, Zhang, Dianhong, Luo, Robert, Miao, Lanfang, Bai, Qingyuan, Ge, William C, Sessa, Wang, Min   +6 more
openaire   +2 more sources

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

Cells, 2020
: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj   +1 more source

Interaction of ALG‐2 with ASK1 influences ASK1 localization and subsequent JNK activation [PDF]

FEBS Letters, 2002
ALG‐2 (apoptosis linked gene‐2) is an essential protein for the execution of apoptosis whose function is largely unknown. Here, we demonstrate that ALG‐2 could interact with the C‐terminus (amino acids 941–1375) of the apoptosis signal‐regulating kinase 1 (ASK1) in BOSC23 cells as well as in vitro.
Hwang, In-Sik, Jung, Yong-Sam, Kim, Eunhee   +2 more
openaire   +2 more sources

Deletion of apoptosis signal-regulating kinase 1 (ASK1) protects pancreatic beta-cells from stress-induced death but not from glucose homeostasis alterations under pro-inflammatory conditions. [PDF]

PLoS ONE, 2014
BACKGROUND:Type 2 diabetes is characterized by pancreatic beta-cell dysfunction and is associated with low-grade inflammation. Recent observations suggest that apoptosis signal-regulating kinase 1 (ASK1) is involved in beta-cell death in response to ...
Emilie Pepin, Arisa Higa, Carole Schuster-Klein, Catherine Bernard, Thierry Sulpice, Beatrice Guardiola, Eric Chevet, Thierry Alquier   +7 more
doaj   +1 more source

Role of the ASK1-SEK1-JNK1-HIPK1 Signal in Daxx Trafficking and ASK1 Oligomerization [PDF]

Journal of Biological Chemistry, 2003
Overexpression of JNK binding domain inhibited glucose deprivation-induced JNK1 activation, relocalization of Daxx from the nucleus to the cytoplasm, and apoptosis signal-regulating kinase 1 (ASK1) oligomerization in human prostate adenocarcinoma DU-145 cells.
Jae J, Song, Yong J, Lee
openaire   +3 more sources