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ASK1-mediated Apoptosis in Human Lung Fibroblasts
PhysiologyIdiopathic pulmonary fibrosis (IPF) is a chronic, devastating lung disease characterized by progressive fibrosis and dysregulated wound repair that negatively affect lung function. Although lung fibroblasts are important in repair mechanisms following lung injury, differentiation into myofibroblasts in the presence of TGF-β and resistance to apoptosis
Emily Huffman +6 more
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ASK1 Regulates Bleomycin-induced Pulmonary Fibrosis
Free Radical Biology and Medicine, 2023Samuel dos Santos Valenca +3 more
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Studium interakcí ASK1 kinasy s thioredoxinem.
2014MAP kinase signaling cascade plays an important role in the cellular response to various stress stimuli from the external environment. This signaling cascade is divided into three levels: MAP kinase kinase kinases (MAP3K) phosphorylate and thus activate MAP kinase kinases (MAP2K) and those subsequently phosphorylate and thus activate MAP kinase (MAPK ...
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ASK1 inhibition: a therapeutic strategy with multi-system benefits
Journal of Molecular Medicine, 2020Jacqueline M Ogier, Paul J Lockhart
exaly