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Exprese a purifikace kinasove domény ASK1 kinasy.
2010The goal of this diploma thesis was to find optimal conditions for expression of ASK1 kinase in prokaryotic expression system and to optimize purification protocol which enables preparing of milligram amounts of stable and soluble protein. Different conditions of expression were tested in E.
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Studium struktury komplexu ASK1 kinasy s thioredoxinem.
20155 ABSTRACT The mitogen-activated protein kinase (MAPK) cascade is an essential member of the cell defense system against stressors. The capability and efficiency of the cell reactions to different stress signals depend on signal transduction pathway, where signals from MAPK kinase kinase (MAP3K) are transferred through phosphorylation to downstream ...
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Biofyzikální charakterizace N-koncové části proteinkinasy ASK1.
2019Apoptosis signal-regulating kinase 1 (ASK1) is an apical kinase of the mitogen-activated protein kinase cascade. Its activity is triggered by various stress stimuli such as reactive oxygen species (ROS), cytokines, endoplasmic reticulum (ER) stress or osmotic stress resulting in the activation of p38 and c-Jun N-terminal kinase metabolic pathways and ...
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Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation
Cell Death and Differentiation, 2004exaly
ASK1 Inhibition Attenuates Elastase-Induced Pulmonary Emphysema
American Journal of Respiratory and Critical Care MedicineS. Dos Santos Valenca +7 more
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Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury
Cell Death and Differentiation, 2012exaly