Results 31 to 40 of about 10,661 (224)
Dynamics of physical interaction between HIV-1 Nef and ASK1: identifying the interacting motif(s). [PDF]
PLoS ONE, 2013 FasL mediated preferential apoptosis of bystander CTLs while protection of infected CD4(+)T cells remains one of the hallmarks of immune evasion during HIV infection.
Balawant Kumar +7 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2019 Background Metformin, a first-line drug for type 2 diabetes, could induce apoptosis in cancer cells. However, the concentration of glucose affects the effect of metformin, especially low glucose in the culture medium can enhance the cytotoxicity of ...
Liwei Ma +8 more
doaj +1 more source
The sooner, the better: ROS, kinases and nutrients at the onset of the damage response in Drosophila
Frontiers in Cell and Developmental Biology, 2022 One of the main topics in regeneration biology is the nature of the early signals that trigger the damage response. Recent advances in Drosophila point to the MAP3 kinase Ask1 as a molecular hub that integrates several signals at the onset of ...
Florenci Serras
doaj +1 more source
Microspherule protein 2 associates with ASK1 and acts as a negative regulator of stress‐induced ASK1 activation [PDF]
FEBS Letters, 2012 ASK1 and MCRS2 colocalize by fluorescence microscopy ( View interaction )
Xu, Mafei +4 more
openaire +2 more sources
Apoptosis signal-regulating kinase 1 mediates MPTP toxicity and regulates glial activation. [PDF]
PLoS ONE, 2012 Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase 3 family, is activated by oxidative stress. The death-signaling pathway mediated by ASK1 is inhibited by DJ-1, which is linked to recessively inherited ...
Kang-Woo Lee +10 more
doaj +1 more source
PIM1 phosphorylates and negatively regulates ASK1-mediated apoptosis [PDF]
Oncogene, 2009 The serine/threonine kinase, PIM1, is involved in promoting cell survival in part by phosphorylation and inhibition of proapoptotic proteins. Apoptosis signaling kinase 1 (ASK1), a mitogen-activated protein kinase kinase kinase, is involved in the so-called stress-activated pathways that contribute to apoptotic cell death.
Gu, Juan Jenny +3 more
openaire +2 more sources
Deletion of ASK1 Protects against Hyperoxia-Induced Acute Lung Injury. [PDF]
PLoS ONE, 2016 Apoptosis signal-regulating kinase 1 (ASK1), a member of the MAPK kinase kinase kinase (MAP3K) family, is activated by various stimuli, which include oxidative stress, endoplasmic reticulum (ER) stress, calcium influx, DNA damage-inducing agents and ...
Jutaro Fukumoto +7 more
doaj +1 more source
Depletion of ASK1 blunts stress-induced senescence in adipocytes
Adipocyte, 2020 Increasing energy expenditure via induction of browning in white adipose tissue has emerged as a potential strategy to treat obesity and associated metabolic complications. We previously reported that ASK1 inhibition in adipocytes protected from high-fat
Stephan Wueest +4 more
doaj +1 more source
PLoS ONE, 2015 The reactive oxygen species (ROS)-sensitive apoptosis signal-regulating kinase 1 (ASK1) signaling complex is a key regulator of p38 MAPK activity, a major modulator of stress-associated with aging disorders.
Reynolds K Brobey +4 more
doaj +1 more source
Role of GALNT4 in protecting against cardiac hypertrophy through ASK1 signaling pathway
Cell Death and Disease, 2021 Pathological myocardial hypertrophy is regulated by multiple pathways. However, its underlying pathogenesis has not been fully explored. The goal of this work was to elucidate the function of polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) in ...
Bin-Bin Zhang +9 more
doaj +1 more source