Results 41 to 50 of about 10,661 (224)

Structural Insights Support Targeting ASK1 Kinase for Therapeutic Interventions [PDF]

International Journal of Molecular Sciences, 2021
Apoptosis signal-regulating kinase (ASK) 1, a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, modulates diverse responses to oxidative and endoplasmic reticulum (ER) stress and calcium influx. As a crucial cellular stress sensor, ASK1 activates c-Jun N-terminal kinases (JNKs) and p38 MAPKs.
Veronika Obsilova, Karolina Honzejkova, Tomas Obsil   +2 more
openaire   +2 more sources

Production, antimicrobial, antioxidant, sensory, and therapeutic properties of herbal wine – A comprehensive review

Journal of Applied Botany and Food Quality
Wine is a fermented beverage. Herbal-infused wine is beneficial to health due to its antimicrobial and anticancer properties. The constituents of these plants, including flowers, fruits, stems, roots, bark, and leaves, contain antioxidant activity.
Sivaniraji Mariappan Kumaresan, Ramaraj Sathasivam, Harshitha Somanathan, Salini Sivaram, Divina Christopher, Anitha Anbalagan, Meenakshi Sundaram Muthuraman, Sang Un Park   +7 more
doaj   +1 more source

Stressed platelets ASK1 for a MAPK [PDF]

Blood, 2017
In this issue of Blood, Naik et al evaluate the link between platelet stimulation and mitogen-activated protein kinase (MAPK) activation and find a critical role for apoptosis signal-regulating kinase 1 (ASK1) in platelet function and thrombus formation ...
openaire   +2 more sources

Laminar flow inhibits TNF-induced ASK1 activation by preventing dissociation of ASK1 from its inhibitor 14-3-3 [PDF]

Journal of Clinical Investigation, 2001
The inflammatory cytokine TNF-alpha stimulates several presumed pro-atherogenic signaling events in endothelial cells (ECs), including activation of c-Jun NH(2)-terminal kinase (JNK) and induction of E-selectin. Here, we show that apoptosis signal-regulating kinase 1 (ASK1), a MAP kinase kinase kinase, is required for TNF-mediated JNK activation.
Y, Liu, G, Yin, J, Surapisitchat, B C, Berk, W, Min   +4 more
openaire   +2 more sources

Thioredoxin Promotes ASK1 Ubiquitination and Degradation to Inhibit ASK1-Mediated Apoptosis in a Redox Activity-Independent Manner [PDF]

Circulation Research, 2002
It has been shown that thioredoxin (Trx) in a reduced form binds to and inhibits apoptosis signal-regulating kinase 1 (ASK1). Apoptotic stimuli such as tumor necrosis factor (TNF) and reactive oxygen species (ROS) activate ASK1 in part by oxidizing Trx (forming intramolecular disulfide between C32 and C35) to release Trx from ASK1.
Yingmei, Liu, Wang, Min
openaire   +2 more sources

AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3 [PDF]

Journal of Clinical Investigation, 2003
TNF-alpha activates ASK1 in part by dissociating 14-3-3 from apoptosis signal-regulating kinase 1 (ASK1). In the present study, we identified a novel Ras GTPase-activating protein (Ras-GAP) as an ASK1-interacting protein (AIP1). AIP1 binds to the C-terminal domain of ASK1 via a lysine-rich cluster within the N-terminal C2 domain.
Rong, Zhang, Xiangrong, He, Weimin, Liu, Meng, Lu, Jer-Tsong, Hsieh, Wang, Min   +5 more
openaire   +2 more sources

Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain

Journal of Neuroinflammation, 2019
Background Neuropathic pain is a serious clinical problem that needs to be solved urgently. ASK1 is an upstream protein of p38 and JNK which plays important roles in neuroinflammation during the induction and maintenance of chronic pain.
Danli Zhou, Siqi Zhang, Liang Hu, Yu-Feng Gu, Yimei Cai, Deqin Wu, Wen-Tao Liu, Chun-Yi Jiang, Xiangqing Kong, Guang-Qin Zhang   +9 more
doaj   +1 more source

ASK1: a new therapeutic target for kidney disease [PDF]

American Journal of Physiology-Renal Physiology, 2016
Stress-induced activation of p38 MAPK and JNK signaling is a feature of both acute and chronic kidney disease and is associated with disease progression. Inhibitors of p38 MAPK or JNK activation provide protection against inflammation and fibrosis in animal models of kidney disease; however, clinical trials of p38 MAPK and JNK inhibitors in other ...
Greg H, Tesch, Frank Y, Ma, David J, Nikolic-Paterson   +2 more
openaire   +2 more sources

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Aspirin Eugenol Ester Protects Vascular Endothelium From Oxidative Injury by the Apoptosis Signal Regulating Kinase-1 Pathway

Frontiers in Pharmacology, 2020
Aspirin eugenol ester (AEE) is a new potential pharmaceutical compound possessing anti-inflammatory, anti-cardiovascular disease, and antioxidative stress activity.
Mei-Zhou Huang, Mei-Zhou Huang, Zhen-Dong Zhang, Ya-Jun Yang, Xi-Wang Liu, Zhe Qin, Jian-Yong Li   +6 more
doaj   +1 more source