Results 61 to 70 of about 10,661 (224)

Apoptosis signal-regulating kinase 1 is associated with the effect of claudin-6 in breast cancer

Diagnostic Pathology, 2012
Background Previous studies have demonstrated that claudin-6 functions as a cancer suppressor in human MCF-7 breast cancer cells. The growth inhibitory effect could be attributed to inhibition of cell proliferation and induction of apoptosis. The purpose
Guo Yaxiong, Xu Xiaoming, Liu Zhijing, Zhang Ting, Zhang Xiaowei, Wang Liping, Wang Min, Liu Yuanyuan, Lu Yan, Liu Yunpeng, Quan Chengshi   +10 more
doaj   +1 more source

Hydrogen attenuates postoperative pain through Trx1/ASK1/MMP9 signaling pathway

Journal of Neuroinflammation, 2023
Background Postoperative pain is a serious clinical problem with a poorly understood mechanism, and lacks effective treatment. Hydrogen (H2) can reduce neuroinflammation; therefore, we hypothesize that H2 may alleviate postoperative pain, and aimed to ...
Juan Li, Shirong Ruan, Jinhui Jia, Qian Li, Rumeng Jia, Li Wan, Xing Yang, Peng Teng, Qilin Peng, Ya-dan Shi, Pan Yu, Yinbing Pan, Man-lin Duan, Wen-Tao Liu, Li Zhang, Liang Hu   +15 more
doaj   +1 more source

Single-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control

Cell Reports, 2023
Summary: The chromatin environment at origins of replication is thought to influence DNA replication initiation in eukaryotic genomes. However, it remains unclear how and which chromatin features control the firing of early-efficient (EE) or late ...
Matthias Weiβ, Anna Chanou, Tamas Schauer, Andrey Tvardovskiy, Stefan Meiser, Ann-Christine König, Tobias Schmidt, Elisabeth Kruse, Henning Ummethum, Manuel Trauner, Marcel Werner, Maxime Lalonde, Stefanie M. Hauck, Antonio Scialdone, Stephan Hamperl   +14 more
doaj   +1 more source

14‐3‐3 proteins: Regulators of cardiac excitation–contraction coupling and stress responses

The Journal of Physiology, EarlyView.
Abstract figure legend 14‐3‐3 protein interactions in cardiac regulation. Schematic representation of 14‐3‐3 binding partners in excitation–contraction coupling, transcriptional regulation/development and stress response pathways. Asterisks indicate targets where the exact 14‐3‐3 binding site is unknown.
Heather C. Spooner, Rose E. Dixon
wiley   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

Diarachidonoylphosphoethanolamine induces apoptosis of malignant pleural mesothelioma cells through a Trx/ASK1/p38 MAPK pathway

Journal of Pharmacological Sciences, 2015
1,2-Diarachidonoyl-sn-glycero-3-phosphoethanolamine (DAPE) induces both necrosis/necroptosis and apoptosis of NCI-H28 malignant pleural mesothelioma (MPM) cells.
Ayako Tsuchiya, Yoshiko Kaku, Takashi Nakano, Tomoyuki Nishizaki   +3 more
doaj   +1 more source

L‐Theanine Alleviates Alcohol‐Induced Kidney Injury by Inhibiting the Sphingolipid Metabolism‐S1PR2‐JNK Pathway and Activating the PPARα‐Steroid Synthesis Pathway

Food Frontiers, Volume 7, Issue 1, January 2026.
L‐theanine alleviates alcohol exposure‐induced kidney injury through a multiple mechanisms. ABSTRACT Alcohol exposure induces kidney oxidative stress and inflammatory responses. L‐theanine (LTA) can protect the kidneys through its antioxidant and immunomodulatory effects; however, its role and underlying mechanisms in alleviating alcoholic kidney ...
Xuhui Dang, Jiahao Yang, Simin Tan, Jiayou Gu, Zhihua Gong, Kehong Liu, Wenjun Xiao   +6 more
wiley   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

The Anti-inflammatory Effect of Selonsertib (GS-4997), an ASK1 Inhibitor, on LPS-Stimulated THP-1 Cells [PDF]

, 2023
Fatma Feyza Özkan, Zerrin Cantürk
openalex   +1 more source

Extracellular Vesicles in Nonalcoholic Fatty Liver Disease: Mechanisms and Therapeutic Opportunities

iNew Medicine, Volume 1, Issue 1, December 2025.
The role of extracellular vesicles (EVs) in the progression of nonalcoholic fatty liver disease (NAFLD). Donor cells release EVs containing various molecules such as cholesterol, ceramide, sphingomyelin, miRNA, DNA, proteins, and lipids. These EVs are taken up by multiple recipient cells including Kupffer cells, adipocytes, β cells, adipose tissue ...
Yunsheng Dong, Lei Xiong, Nina Zhu, Zihan Wang, Hanqi Xia, Chen Cheng, Jianshang Huang, Yiran Han, Abduxukur Rahman, Junhao Zhao, Chonggui Jiang, Li Zuo, Hua Wang   +12 more
wiley   +1 more source