Results 81 to 90 of about 10,661 (224)

The Promise of Exosomes in Cardiac Repair: When ‘Best Things Come in Small Packages’

Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.
ABSTRACT Myocardial ischaemia continues to be a predominant global cause of mortality, leaving survivors with compromised quality of life and significant loss of functional cardiomyocytes. The main therapeutic approach, which attempts to restore heart function, generally involves myocardial reperfusion.
Anthony Yazbeck, Zena Wehbe, Yara Menassa, Alaa Abdelhamid, Assaad A. Eid, Amirhossein Sahebkar, Ali H. Eid   +6 more
wiley   +1 more source

Interaction of ASK1 and the β-amyloid precursor protein in a stress-signaling complex

Neurobiology of Disease, 2007
The amyloid precursor protein (APP) is a type I transmembrane protein translocated to neuronal terminals, whose function is still unknown. The C-terminus of APP mediates its interaction with cellular adaptor and signaling proteins, some of which signal ...
Veronica Galvan, Surita Banwait, Patricia Spilman, Olivia F. Gorostiza, Alyson Peel, Marina Ataie, Danielle Crippen, Wei Huang, Gurleen Sidhu, Hidenori Ichijo, Dale E. Bredesen   +10 more
doaj   +1 more source

Endoplasmic Reticulum Stress: A Novel Target for the Prevention and Treatment of Hypertension and Its Related Diseases

Journal of Cellular and Molecular Medicine, Volume 29, Issue 23, December 2025.
ABSTRACT Endoplasmic reticulum stress (ERS) emerges as a critical pathophysiological nexus in hypertension and related cardiovascular diseases. Chronic ERS activation via the IRE1α‐XBP1, ATF6, and PERK pathways drives vascular endothelial dysfunction (reduced NO bioavailability, increased ET‐1), renin‐angiotensin system (RAS) hyperactivation ...
Xin Ma, Fei Si, Jie Ma, Chuyan Feng, Yingdong Wang, Luosha Wang, Jing Yu   +6 more
wiley   +1 more source

NUDIX hydrolases target specific inositol pyrophosphates and regulate phosphate homeostasis and bacterial pathogen susceptibility in Arabidopsis

Journal of Integrative Plant Biology, Volume 67, Issue 12, Page 3123-3151, December 2025.
NUDIX‐type hydrolase enzymes of subclade I and II preferentially target the inositol pyrophosphate messengers 4‐ and 3‐InsP7, respectively. Inactivation of subclade II NUDTs disrupts phosphate homeostasis and enhances bacterial resistance, revealing connections between defense and nutrient signaling.
Robin Schneider, Klea Lami, Isabel Prucker, Sara Christina Stolze, Annett Strauß, Julie Marie Schmidt, Simon M. Bartsch, Kevin Langenbach, Esther Lange, Kevin Ritter, David Furkert, Natalie Faiß, Sandeep Kumar, M. Shamim Hasan, Athanasios Makris, Lukas Krusenbaum, Stefanie Wege, Yemisrach Zewdu Belay, Simon Kriescher, Jeremy The, Michael Harings, Florian M. W. Grundler, Martina K. Ried‐Lasi, Heiko Schoof, Philipp Gaugler, Marília Kamleitner, Dorothea Fiedler, Hirofumi Nakagami, Ricardo F. H. Giehl, Thomas Lahaye, Saikat Bhattacharjee, Henning J. Jessen, Verena Gaugler, Gabriel Schaaf   +33 more
wiley   +1 more source

In vitro dynamic and quantitative monitoring of strigolactone‐signaling complex formation by time‐resolved FRET

The Plant Journal, Volume 124, Issue 5, December 2025.
We developed a new in vitro method using time‐resolved FRET to evaluate the dynamic activation of the strigolactone (SL) receptors. This system was used to gain deeper insights into the molecular mechanism of SL‐signaling complex formation and to detect naturally occurring SLs.
Taiki Suzuki, Kotaro Nishiyama, Yusuke Kato, Chihiro Shinkai, Tomoya Ishikawa, Jekson Robertlee, Michio Kuruma, Shinya Hagihara, Marco Bürger, Kosuke Fukui, Tadao Asami, Yoshiya Seto   +11 more
wiley   +1 more source

Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors

, 2021
Shaohua Hou, Xiping Yang, Yuejing Yang, Tong Yu, Quanwei Chen, Boheng Wan, Ran Wei, Tao Lu, Yadong Chen, Qinghua Hu   +9 more
openalex   +1 more source

Novel ASK1 inhibitor AGI‐1067 improves AGE‐induced cardiac dysfunction by inhibiting MKKs/p38 MAPK and NF‐κB apoptotic signaling

FEBS Open Bio, 2018
Heart failure has been identified as one of the clinical manifestations of diabetic cardiovascular complications. Excessive myocardium apoptosis characterizes cardiac dysfunctions, which are correlated with an increased level of advanced glycation end ...
Zhongwei Liu, Shixiang Zheng, Xi Wang, Chuan Qiu, Yan Guo   +4 more
doaj   +1 more source

ASK1 Is Essential for JNK/SAPK Activation by TRAF2 [PDF]

, 1998
Hideki Nishitoh, Masao Saitoh, Yoshiyuki Mochida, Kohsuke Takeda, Hiroyasu Nakano, Mike Rothe, Kohei Miyazono, Hidenori Ichijo   +7 more
openalex   +1 more source

Lys29-linkage of ASK1 by Skp1−Cullin 1−Fbxo21 ubiquitin ligase complex is required for antiviral innate response

eLife, 2016
Protein ubiquitination regulated by ubiquitin ligases plays important roles in innate immunity. However, key regulators of ubiquitination during innate response and roles of new types of ubiquitination (apart from Lys48- and Lys63-linkage) in control of ...
Zhou Yu, Taoyong Chen, Xuelian Li, Mingjin Yang, Songqing Tang, Xuhui Zhu, Yan Gu, Xiaoping Su, Meng Xia, Weihua Li, Xuemin Zhang, Qingqing Wang, Xuetao Cao, Jianli Wang   +13 more
doaj   +1 more source

Apoptosis signal-regulating kinase 1 promotes inflammation in senescence and aging

Communications Biology
Cellular senescence is a stress-induced, permanent cell cycle arrest involved in tumor suppression and aging. Senescent cells secrete bioactive molecules such as pro-inflammatory cytokines and chemokines.
Takeru Odawara, Shota Yamauchi, Hidenori Ichijo   +2 more
doaj   +1 more source