Results 151 to 160 of about 101,913 (345)

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

Delayed and deferred surgery associated with cenobamate use in people with drug‐resistant focal epilepsy

open access: yesEpilepsia, EarlyView.
Abstract Objective Cenobamate has been shown to be an effective antiseizure medication for some patients with drug‐resistant focal epilepsy being considered for epilepsy surgery. This retrospective single‐center study evaluated whether surgery was obtained within 12 months for patients who received cenobamate as a treatment during the presurgical ...
Jacob Pellinen   +8 more
wiley   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

open access: yesEpilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini   +15 more
wiley   +1 more source

ASMs in Service Oriented Architectures.

open access: green, 2008
Michael Altenhofen   +2 more
openalex   +2 more sources

Serum NfL, GFAP, and p‐tau217 in adults with drug‐resistant epilepsy and intellectual disabilities: Signs of ongoing neural injury

open access: yesEpilepsia, EarlyView.
Abstract Objective Adults with epilepsy and intellectual disabilities (IDs) may be at increased risk of dementia, but clinical evaluation is complex and use of conventional biomarkers is often considered too invasive. We explored abnormality of serum neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and phosphorylated tau‐217 (p ...
Hadassa Kwetsie   +10 more
wiley   +1 more source

Analgesia and control of postoperative shivering

open access: yesPathos
Nefopam hydrochloride was used to prevent and treat postoperative pain and shivering in 350 patients undergoing general anaesthesia (TIVA-TCI and ALR, including CSE, subarachnoid and epidural blocks) for general, gynaecological, orthopaedic and ...
Nicola Maratea, Paolo Salomone
doaj  

Home - About - Disclaimer - Privacy