Results 41 to 50 of about 10,082 (205)

Hybrid Closed-Loop Control with Ultrarapid Lispro Compared with Standard Insulin Aspart and Faster Insulin Aspart: An In Silico Study

, 2021
OBJECTIVE: There is room for improvement in the performance of closed-loop regulation algorithms during the prandial period. This in silico study evaluated the efficiency and safety of ultrarapid lispro insulin using the Diabeloop DBLG1® algorithm ...
Franc, Sylvia, Benhamou, Pierre Yves, Tourki, Yousra, Lachal, Sylvain, Charpentier, Guillaume, Huneker, Erik   +5 more
core   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the West Bengal cohort of the A 1 chieve study

Indian Journal of Endocrinology and Metabolism, 2013
Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care ...
Satinath Mukhopadhyay, Nilanjan Sengupta, Sujoy Ghosh   +2 more
doaj   +1 more source

Non‐Nutritive Artificial Sweeteners Aspartame and Acesulfame‐K Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease in Male Ldlr−/− Mice

iNew Medicine, EarlyView.
ABSTRACT Aspartame and acesulfame‐K are commonly used non‐nutritive artificial sweeteners, but their impacts on cardiovascular disease and metabolic dysfunction‐associated fatty liver disease (MASLD) are unclear. In this study, we evaluated the impacts of aspartame and acesulfame‐K on MASLD and atherosclerosis in male Ldlr−/− mice fed an AMLN diet ...
Jingjing Xu, Xiaohua Jiang, Jianping Weng, Suowen Xu   +3 more
wiley   +1 more source

Clinical experience with insulin detemir, biphasic insulin aspart and insulin aspart in people with type 2 diabetes: Results from the Northern Tunisia cohort of the A 1 chieve study

Indian Journal of Endocrinology and Metabolism, 2013
Background: The A 1 chieve, a multicentric (28 countries), 24-week, non-interventional study evaluated the safety and effectiveness of insulin detemir, biphasic insulin aspart and insulin aspart in people with T2DM (n = 66,726) in routine clinical care ...
Samira Blouza, Henda Jamoussi
doaj   +1 more source

Perioperative glycaemic profiles in Aboriginal and Torres Strait Islander people with diabetes mellitus

Diabetic Medicine, EarlyView.
This large multicentre retrospective cohort study in Australia revealed that despite being younger and having greater preoperative comorbidity and higher HbA1c levels, Aboriginal and Torres Strait Islander adults with diabetes mellitus demonstrate higher rates of perioperative hypoglycaemia, but otherwise comparable markers of glycaemic variability and
Katerina Flabouris, Odette R. Pearson, Kim Morey, Suzanne M. Edwards, David R. Jesudason, Chinmay S. Marathe   +5 more
wiley   +1 more source

Pharmakologische Eigenschaften des schneller wirksamen Insulins aspart (Faster-acting Insulin aspart)

, 2017
ZusammenfassungFaster-acting Insulin aspart ist eine durch die Zugabe der als sicher geltenden Hilfsstoffe Niacinamid und L-Arginin weiterentwickelte Formulierung zu Insulin aspart (IAsp).
Torben Biester, Tim Heise
core   +1 more source

Aspartate kinase and the synthesis of aspartate-derived amino acids in wheat

Planta, 1978
Aspartate kinase (EC 2.7.2.4.) has been purified from 7 day etiolated wheat (Triticum aestivum L. var. Maris Freeman) seedlings and from embryos imbibed for 8 h. The enzyme was 50% inhibited by 0.25 mM lysine. In this study wheat aspartate kinase was not inhibited by threonine alone or cooperatively with lysine; these results contrast with those ...
Bright, S. W. J., Shewry, P. R., Miflin, B. J.   +2 more
openaire   +2 more sources

Physical activity during pregnancy in women with type 1 or type 2 diabetes: A scoping review

Diabetic Medicine, EarlyView.
Abstract Aim Physical activity (PA) is recommended during pregnancy for its health benefits. While general PA guidance exists for uncomplicated pregnancies, evidence specific to women with pre‐existing type 1 diabetes or type 2 diabetes (T1D; T2D) is limited.
Holly Mei Jones, Lolwa Alyafei, Laura Macro, Gina Gardener, Emma Cockcroft, Rob Andrews, Richard M. Pulsford   +6 more
wiley   +1 more source

Clinical Pharmacology of Fast-Acting Insulin Aspart Versus Insulin Aspart Measured as Free or Total Insulin Aspart and the Relation to Anti-Insulin Aspart Antibody Levels in Subjects with Type 1 Diabetes Mellitus

, 2019
BACKGROUND: Fast-acting insulin aspart (faster aspart) is an ultra-fast-acting formulation of insulin aspart (IAsp). This post hoc analysis investigated the pharmacokinetics of faster aspart versus IAsp, measured as free or total IAsp, and the ...
Haahr, Hanne, Heise, Tim, Gondolf, Theis, Erichsen, Lars, Pieber, Thomas R., Shiramoto, Masanari, Mathieu, Chantal   +6 more
core   +1 more source