Biology, 2021 Background: Aspartame is an artificial sweetener used in foods and beverages worldwide. However, it is linked to oxidative stress, inflammation, and liver damage through mechanisms that are not fully elucidated yet.
Isabela A. Finamor +7 more
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No indication of histological changes in embryonic somatosensory cortex development upon maternal aspartame consumption in mice [PDF]
npj Science of FoodNon-nutritive sweeteners are widely used in multiple diets and are considered a healthy alternative for pregnant women reducing sugar consumption, thereby preventing maternal obesity and gestational diabetes.
Liliia Andriichuk, Takashi Namba
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Aspartame and ischemic stroke: unraveling the molecular link through network toxicology and molecular docking analysis [PDF]
Scientific ReportsAspartame, a widely used artificial sweetener, remains controversial due to neurotoxic risks from its metabolites—phenylalanine, aspartic acid, and methanol.
Tianyu Zhang +4 more
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Analysis of toxicity and mechanisms of aspartame in kidney stones with network toxicology and molecular docking strategy [PDF]
Scientific ReportsAspartame, an artificial sweetener, has been implicated in the formation of kidney stones, although the underlying mechanisms remain poorly understood.
Kailiang Xu +4 more
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Metagenomics and transcriptomics analysis of aspartame’s impact on gut microbiota and glioblastoma progression in a mouse model [PDF]
Scientific ReportsAspartame, a widely used artificial sweetener, has been extensively studied for its potential health effects. Emerging evidence suggests that aspartame intake may directly impact the composition and function of the intestinal microbiota, which could ...
Kaikai Meng +8 more
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BioLink, 2022 Aspartame is an artificial sweetener in foods and beverages. Continuous use of aspartame will result in oxidative stress in the liver. So we need antioxidants from outside the body such as periwinkle leaves.This study aims to determine the effect of ...
Mahriani Mahriani +2 more
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Genotoxicity of Aspartame [PDF]
Drug and Chemical Toxicology, 2004 In the present study, the genotoxic effects of the low-calorie sweetener aspartame (ASP), which is a dipeptide derivative, was investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test, micronucleus test in human lymphocytes and also Ames/Salmonella/ microsome test.
Rencüzogullari E. +6 more
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Low-dose aspartame consumption differentially affects gut microbiota-host metabolic interactions in the diet-induced obese rat. [PDF]
PLoS ONE, 2014 Aspartame consumption is implicated in the development of obesity and metabolic disease despite the intention of limiting caloric intake. The mechanisms responsible for this association remain unclear, but may involve circulating metabolites and the gut ...
Marie S A Palmnäs +7 more
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Histopathological and the Dose Depended Effects of Aspartame toxicity on Liver and Kidney of Rats [PDF]
Journal of Applied Veterinary Sciences, 2023 Aspartame is a commonly employed artificial sweetener used by hyperglycemic patients and in food management. Its danger depends on the outcome of previous studies that revealed controversy. The purpose of this study was to look into the histopathological
Omar Azez +3 more
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Gender dimorphism in aspartame-induced impairment of spatial cognition and insulin sensitivity. [PDF]
PLoS ONE, 2012 Previous studies have linked aspartame consumption to impaired retention of learned behavior in rodents. Prenatal exposure to aspartame has also been shown to impair odor-associative learning in guinea pigs; and recently, aspartame-fed hyperlipidemic ...
Kate S Collison +7 more
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