Results 41 to 50 of about 20,129 (222)

Pathologists' perspective on the study design, analysis, and interpretation of proliferative lesions in lifetime and prenatal rodent carcinogenicity bioassays of aspartame.

Food and Chemical Toxicology, 2022
Aspartame, an artificial sweetener commonly used as a sugar substitute, is currently authorized for use in more than 100 countries. Hundreds of studies, conducted in various countries dating back to the 1970s, have shown that aspartame is safe at real ...
S. Elmore, J. Rehg, T. Schoeb, J. Everitt, B. Bolon   +4 more
semanticscholar   +1 more source

Aspartame Consumption, Mitochondrial Disorder-Induced Impaired Ovarian Function, and Infertility Risk

International Journal of Molecular Sciences, 2022
Frequent consumption of diet drinks was associated with oocyte dysmorphism, decreased embryo quality, and an adverse effect on pregnancy rate. We investigated the harmful effects of aspartame and potential mechanisms through which it increases ...
Y. Chen, Yen-Chia Yeh, Yu-Fang Lin, H. Au, S. Hsia, Yue‐Hwa Chen, R. Hsieh   +6 more
semanticscholar   +1 more source

Protective effects of some antioxidants against long-term intake of aspartame toxicity on liver and kidney: biochemical and histopathological approach in rats

Journal of Basic and Applied Zoology, 2021
Background Aspartame is used to treat obesity, and the diabetic people could induce changes in liver and kidney structures and function. Garlic extract, melatonin and thymoquinone have an important role against aspartame toxicity due to their antioxidant
Sary Kh. Abdel-ghaffar, Mohamed Araf Adly, Mohamed F. El-Sayed, Walaa Magdy Abd-Elsamei   +3 more
doaj   +1 more source

The Associations between Maternal Serum Aspartame and Sucralose and Metabolic Health during Pregnancy

Nutrients, 2022
Objective: We aimed to investigate the associations between maternal serum aspartame/sucralose levels and metabolic health during pregnancy. Methods: A nested population-based case-control study was conducted in 109 women with and without gestational ...
Yu Liu, Xiaoyong Li, Yiming Wu, Q. Su, Li Qin, Jing Ma   +5 more
semanticscholar   +1 more source

Examination of the Potential for Adaptive Chirality of the Nitrogen Chiral Center in Aza-Aspartame

Molecules, 2013
The potential for dynamic chirality of an azapeptide nitrogen was examined by substitution of nitrogen for the α-carbon of the aspartate residue in the sweetener S,S-aspartame.
Samir H. Bouayad-Gervais, William D. Lubell   +1 more
doaj   +1 more source

Sweetener aspartame aggravates atherosclerosis through insulin-triggered inflammation.

Cell Metabolism
Consumption of artificial sweeteners (ASWs) in various foods and beverages has been linked to an increased risk of cardiovascular diseases (CVDs). However, molecular mechanisms underlying ASW-associated CVD remain unknown.
Weijie Wu, Wenhai Sui, Sizhe Chen, Ziheng Guo, Xu Jing, Xiaolu Wang, Qun Wang, Xinshuang Yu, Wenjing Xiong, Jiansong Ji, Libo Yang, Yuan Zhang, Wenjing Jiang, Guohua Yu, Shuzhen Liu, Wei Tao, Chen Zhao, Yun Zhang, Yuguo Chen, Cheng Zhang, Yihai Cao   +20 more
semanticscholar   +1 more source

Enzymatic spectrophotometric reaction rate determination of aspartame [PDF]

Hemijska Industrija, 2015
Aspartame is an artificial sweetener of low caloric value (approximately 200 times sweeter than sucrose). Aspartame is currently permitted for use in food and beverage production in more than 90 countries.
Trifković Kata T., Łękawska-Andrinopoulou Lucyna, Bugarski Branko M., Georgiou Constantinos A.   +3 more
doaj   +1 more source

The Effects of Non-Nutritive Artificial Sweeteners, Aspartame and Sucralose, on the Gut Microbiome in Healthy Adults: Secondary Outcomes of a Randomized Double-Blinded Crossover Clinical Trial

Nutrients, 2020
Non-nutritive artificial sweeteners (NNSs) may have the ability to change the gut microbiota, which could potentially alter glucose metabolism. This study aimed to determine the effect of sucralose and aspartame consumption on gut microbiota composition ...
Samar Y Ahmad, J. Friel, D. Mackay
semanticscholar   +1 more source

The effect of aspartame and sucralose intake on body weight measures and blood metabolites: role of their form (solid and/or liquid) of ingestion

British Journal of Nutrition, 2021
The ingestion of non-caloric sweeteners (NCS) from food and/or drink was intended to reduce caloric intake without compromising palatability. However, the inconclusive relation between NCS and body weight may partially relate to their form of ingestion ...
M. Ragi, Rachelle El-Haber, Fidele El-Masri, O. Obeid   +3 more
semanticscholar   +1 more source

Analysis of the Effects of Food Additives on Porphyromonas gingivalis

Pathogens, 2022
This study aims to investigate six food additives (octanoic acid, decanoic acid, acesulfame K, aspartame, saccharin, and sucralose) used in foods for the elderly or people with dysphagia because of the effect of these food additives on Porphyromonas ...
Mai Shinohara, Miki Maetani, Chiharu Kitada, Yasuko Nishigami, Ayaka Yazawa, Shigeki Kamitani   +5 more
doaj   +1 more source