Results 121 to 130 of about 189,959 (292)

Evidence that ³¹P NMR is a sensitive indicator of small conformational changes in the coenzyme of aspartate aminotransferase [PDF]

, 1989
Klaus D. Schnackerz, Gudrun WAHLER, M. G. Vincent, Johan N. Jansonius   +3 more
openalex   +1 more source

Macro-AST as a cause of isolated increase of aspartate aminotransferase in an asymptomatic patient [PDF]

, 2021
Markéta Veverková, Jakub Pecl, Tereza Pinkasová, Zdeňka Čermáková, Petr Jabandžiev   +4 more
openalex   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

Elevated Aspartate Aminotransferase to Alanine Aminotransferase Ratio Predicts Poor Outcome in Hepatocellular Carcinoma

Hepatology Communications, 2020
Johann von Felden, Henning Wege, Kornelius Schulze   +2 more
doaj   +1 more source

Association Between Aspartate Aminotransferase to Alanine Aminotransferase Ratio and Incidence of Type 2 Diabetes Mellitus in the Japanese Population: A Secondary Analysis of a Retrospective Cohort Study

, 2021
Lidan Chen, Kebao Zhang, Xue Li, Yang Wu, Qingwen Liu, Liting Xu, Liuyan Li, Haofei Hu   +7 more
openalex   +2 more sources

USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer

Advanced Science, EarlyView.
USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen, Ling Wang, Hongmei Fan, Lisheng Li, Lingyu Zhang, Ruoxin Li, Fang Liu, Fuli Wen, Yunbin Ye, Chuanzhong Huang   +9 more
wiley   +1 more source

Iron/Cobalt Dual‐Atom Catalyst Orchestrate Photothermal‐Chemodynamic Immunotherapy Against MRSA: Multi‐Omics Dissection in Murine and Porcine Models

Advanced Science, EarlyView.
FeCo dual‐atom catalyst (FeCo‐N‐DAC) with ultrahigh metal loading (Fe > 5.4%, Co > 4.8%) is developed for synergistic photothermal‐chemodynamic immunotherapy. FeCo‐N‐DAC penetrates deep‐seated tissues, eradicates MRSA biofilms, and reprograms immune‐inflammatory pathways via multi‐omics‐validated mechanisms.
Shihao Xu, Binge Huang, Hao Lin, Jinming Li, Zhaoxiang Lu, Qi Zhang, Jia Li, Shiping Yang, Songsong Lan, Yan Yang, Yun Feng, Xiaojun He   +11 more
wiley   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, EarlyView.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Basic : Upper Limit of normal alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and its modulating factors in Korean (초) [PDF]

, 2011
Dae Won Jun, Won Sohn, Tae Yeob Kim, Joo Hyun Sohn, Min Ho Lee   +4 more
openalex  

Degradation of the precursor of mitochondrial aspartate aminotransferase in chicken embryo fibroblasts.

, 1988
J Flückiger, Philipp Christen
openalex   +1 more source