Results 151 to 160 of about 189,959 (292)

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Aspartate aminotransferase to platelet ratio index (APRI) for differentiation of primary and secondary infection by dengue virus

, 2018
Suellen Rodrigues Martins, Melina de Barros Pinheiro, Luci Maria Sant’Ana Dusse, Ana Paula Lucas Mota, Patrícia Nessralla Alpoim   +4 more
openalex   +1 more source

Fluorescence of Aromatic Amino Acids in a Pyridoxal Phosphate Enzyme: Aspartate Aminotransferase [PDF]

, 1978
Martine Arrio‐Dupont
openalex   +1 more source

Universal Antibody‐Engineered Lipid Nanoparticles Potentiate Chemo‐Immunotherapy Against Triple‐Negative Breast Cancer by Reprogramming Tumor Cell Metabolism

Advanced Science, EarlyView.
A universal ROR1 antibody‐engineered lipid nanoparticle (LNP) is constructed by sequential drug encapsulation and antibody conjugation. The LNP not only enables enhanced chemotherapeutic efficiency by targeting drug delivery and precise localization of deep‐seated tumors through NIR‐II fluorescence imaging, but also remodels immunosuppressive TME ...
Yeneng Dai, Jiaqi Wang, Yu Liu, Guanda Jiao, Yuheng Gu, Yang Liu, Shengyu Fu, Xing Fan, Jialin Li, Ziang Guo, Kam Tong Leung, Lipeng Zhu, Qi Zhao   +12 more
wiley   +1 more source

Identification of SNP Markers in the Glutamate Dehydrogenase (GDH) and Aspartate Aminotransferase 2 (AST2) Associated with Ammonia Nitrogen Tolerance in <i>Penaeus monodon</i>. [PDF]

Biology (Basel)
Ding Y, Chen J, Jiang S, Yang Q, Li Y, Huang J, Yang L, Shi J, Yu Y, Jiang S, Zhou F.   +10 more
europepmc   +1 more source

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Exploring the Association Between Periodontal Inflammation and Serum Aspartate Aminotransferase: Findings From a Longitudinal Study Among the Japanese Older Population. [PDF]

J Int Soc Prev Community Dent
Chairunisa F, Takehara S, Nohno K, Ogawa H.   +3 more
europepmc   +1 more source

Conformation of Aspartate Aminotransferase Isozymes Folding under Different Conditions Probed by Limited Proteolysis

, 1998
Joseph R. Mattingly, Claudia Torella, Ana Iriarte, Marino Martinez‐Carrion   +3 more
openalex   +1 more source

Cytosolic Aspartate Aminotransferase Encoded by the AAT2 Gene is Targeted to the Peroxisomes in Oleate‐Grown Saccharomyces Cerevisiae [PDF]

, 1997
Nicolette Verleur, Ype Elgersma, Carlo W.T. van Roermund, Henk F. Tabak, Ronald J. A. Wanders   +4 more
openalex   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source