Results 151 to 160 of about 16,662 (295)

AI‐Based D‐Amino Acid Substitution for Optimizing Antimicrobial Peptides to Treat Multidrug‐Resistant Bacterial Infection

Advanced Science, EarlyView.
This study constructed the first D‐amino acid antimicrobial peptide dataset and developed an AI model for efficient screening of substitution sites, with 80% of candidate peptides showing enhanced activity. The lead peptide dR2‐1 demonstrated potent antimicrobial activity in vitro and in vivo, high stability, and low toxicity.
Yinuo Zhao, Qingzhou Kong, Haifan Gong, Lixiang Li, Jialu Fu, Boyao Wan, Peizhu Wang, Xiaojuan Li, Yue Wang, Jinghui Zhang, Yanbo Yu, Xiaoyun Yang, Xiuli Zuo, Haina Wang, Yanqing Li   +14 more
wiley   +1 more source

Case Report: Elevated Aminotransferases and Altered Hepatic Perfusion due to Retroperitoneal Paraganglioma. [PDF]

GE Port J Gastroenterol
Freitas GM, Heringer CT, Dos Santos ÉL, de Souza CO, Pereira Soares SR, Wahle RC.   +5 more
europepmc   +1 more source

Aspartate aminotransferase to platelet ratio index (APRI) for differentiation of primary and secondary infection by dengue virus

, 2018
Suellen Rodrigues Martins, Melina de Barros Pinheiro, Luci Maria Sant’Ana Dusse, Ana Paula Lucas Mota, Patrícia Nessralla Alpoim   +4 more
openalex   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Managing Aminotransferase Elevations in Patients with Friedreich Ataxia Treated with Omaveloxolone: A Review and Expert Opinion on Use Considerations. [PDF]

Neurol Ther
Perlman S, Anheim M, Boesch S, Lewis JH, Lynch DR.   +4 more
europepmc   +1 more source

Cytosolic Aspartate Aminotransferase Encoded by the AAT2 Gene is Targeted to the Peroxisomes in Oleate‐Grown Saccharomyces Cerevisiae [PDF]

, 1997
Nicolette Verleur, Ype Elgersma, Carlo W.T. van Roermund, Henk F. Tabak, Ronald J. A. Wanders   +4 more
openalex   +1 more source

Ambulatory end-stage liver disease in Ghana; patient profile and utility of alpha fetoprotein and aspartate aminotransferase - platelet ratio index. [PDF]

, 2020
Yvonne Ayerki Nartey, Yaw Asante Awuku, Adwoa Agyei‐Nkansah, Amoako Duah, Sally Afuah Bampoh, Joshua Ayawin, Shadrack Osei Asibey, Niklas K. Björkström, Weimin Ye, Mary Afihene, Lewis R. Roberts, Amelie Plymoth   +11 more
openalex   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

An Immunocompetent Host With Severe Disseminated Herpes Simplex Virus Type 2 Infection With Hepatorenal Involvement. [PDF]

Cureus
Baloch S, Wasio A, Shiferaw B, Khan A, Khan SR.   +4 more
europepmc   +1 more source

Conformation of Aspartate Aminotransferase Isozymes Folding under Different Conditions Probed by Limited Proteolysis

, 1998
Joseph R. Mattingly, Claudia Torella, Ana Iriarte, Marino Martinez‐Carrion   +3 more
openalex   +1 more source