Results 71 to 80 of about 186,010 (406)

Hepatoprotective potential of Tamarindus indica following prenatal aluminum exposure in Wistar rat pups

Toxicology Reports, 2023
Over time, the use of plant-derived agents in the management of various human health conditions has gained a lot of attention. The study assessed the hepatoprotective potential of ethyl acetate fraction Tamarindus indica leaves (EFTI) during prenatal ...
Helen Ruth Yusuf, Sunday Abraham Musa, Abel Nosereme Agbon, Ejike Daniel Eze, Akeem Ayodeji Okesina, Ismail Onanuga, Theophilus Pius, Victor Archibong, Mario Edgar Fernandez Diaz, Juma John Ochieng, Nicholas Kusiima, Bot Yakubu Sunday, Ibe Michael Usman   +12 more
doaj  

A Mathematical model for Astrocytes mediated LTP at Single Hippocampal Synapses [PDF]

, 2011
Many contemporary studies have shown that astrocytes play a significant role in modulating both short and long form of synaptic plasticity. There are very few experimental models which elucidate the role of astrocyte over Long-term Potentiation (LTP).
arxiv   +1 more source

Optimizing Angiopep‐2 Density on Polymeric Nanoparticles for Enhanced Blood–Brain Barrier Penetration and Glioblastoma Targeting: Insights From In Vitro and In Vivo Experiments

Advanced Functional Materials, EarlyView.
The Angiopep‐2 peptide density on polymeric nanoparticles significantly impacts blood–brain barrier (BBB) penetration. This study explores this nuanced relationship using various in vitro models and in vivo assays, revealing that dynamic models better predict BBB penetration.
Weisen Zhang, Ahmed Refaat, Haoqin Li, Douer Zhu, Ziqiu Tong, Joseph Anthony Nicolazzo, Bo Peng, Hua Bai, Lars Esser, Nicolas Hans Voelcker   +9 more
wiley   +1 more source

Elevated serum levels of aminotransferases in relation to unhealthy foods intake: Tehran lipid and glucose study

BMC Endocrine Disorders, 2019
Background Abnormal levels of liver enzymes, particularly aminotransferases, are prognostic features of non-alcoholic fatty liver disease (NAFLD). Considering the important role of dietary intakes in development of NAFLD, we aimed to determine possible ...
Parvin Mirmiran, Zahra Gaeini, Zahra Bahadoran, Fereidoun Azizi   +3 more
doaj   +1 more source

Functional state and protein-synthesizing function of the liver of laying hens under conditions of cadmium loading [PDF]

, 2023
The toxicity of cadmium in the bird's body depends on the penetration method, the total dose, and the duration of poisoning. That is why the work aimed to study the effect of Cadmium on liver function disorders.
Demus, N. V., Gutyj, B. V., Horalskyi, L. P., Hunchak, A. V., Hunchak, V. M., Khariv, I. I., Kraikivska, H. Yu., Martyshuk, T. V., Slobodiuk, N. M., Sokulskyi, I. M., Vus, U. M.   +10 more
core   +2 more sources

Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation

Advanced Functional Materials, EarlyView.
A biomimetic nanomedicine (RBLN) constructed by loading natural antioxidants to clinically used layered double hydroxide nanoparticles is surface coated with fresh or senescent red blood cell membrane for balanced drug delivery to hepatocytes and KCs, thereby simultaneously alleviating liver oxidant stress and inflammation for effective drug‐induced ...
Jiahui Shao, Maoze Wang, Jinling Huang, Yu Wang, Jing Zhao, Ran Wang, Zhi Ping Xu, Jianping Jiang, Lingxiao Zhang   +8 more
wiley   +1 more source

Computational Study of pKa shift of Aspartate residue in Thioredoxin: Role of Configurational Sampling and Solvent Model [PDF]

arXiv, 2022
Alchemical free energy calculations are widely used in predicting pKa, and binding free energy calculations in biomolecular systems. These calculations are carried out using either Free Energy Perturbation (FEP) or Thermodynamic Integration (TI). Numerous efforts have been made to improve the accuracy and efficiency of such calculations, especially by ...
arxiv  

Lack of complete biochemical response in autoimmune hepatitis leads to adverse outcome: First report of the IAIHG retrospective registry [PDF]

, 2023
Background and Aims: The International Autoimmune Hepatitis Group retrospective registry (IAIHG-RR) is a web-based platform with subjects enrolled with a clinical diagnosis of autoimmune hepatitis (AIH). As prognostic factor studies with enough power are
, , Andrade, Raúl J., Bouma, Gerd, Colapietro, Francesca, Dalekos, George N., De Boer, Ynto S., Di Zeo-Sánchez, Daniel E., Kerkar, Nanda, Lenzi, Marco, Liberal, Rodrigo, Lissenberg-Witte, Birgit I., Lleo, Ana, Lucena, M. Isabel, Lytvyak, Ellina, MacEdo, Guilherme, Maisonneuve, Patrick, Montano-Loza, Aldo J., Muratori, Paolo, Robles-Díaz, Mercedes, Slooter, Charlotte D., Van Den Brand, Floris F., Zachou, Kalliopi   +22 more
core   +2 more sources

Specificity of aspartate aminotransferases from leguminous plants for 4-substituted glutamic acids.

Plant Physiology, 1989
Aspartate aminotransferase (glutamate-oxalacetate transaminase) was partially purified from extracts of germinating seeds of peanut (Arachis hypogaea), honey locust (Gleditsia triacanthos), soybean (Glycine max), and Sophora japonica.
H. C. Winter, E. E. Dekker
semanticscholar   +1 more source

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source