Regulating Enzyme Activity via Microaggregates Mediated by Phase Separation
An enzyme‐sequestration strategy for combating postoperative pancreatic fistula (POPF) is developed, employing a D‐peptide called DPMD to induce liquid–solid phase separation (LSPS) of pancreatic proteases. This LSPS‐driven microaggregate approach effectively isolates trypsin and chymotrypsin from their substrates, thereby reducing pancreatic fluid ...
Yang Wang+7 more
wiley +1 more source
Aspartate transaminase to platelet ratio index (APRI) but not FIB-5 or FIB-4 is accurate in ruling out significant fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) in an urban slum-dwelling population. [PDF]
Kolhe KM+9 more
europepmc +1 more source
Elevated serum lactate dehydrogenase isoenzymes and aspartate transaminase distinguish Albers-Schönberg disease (Chloride Channel 7 Deficiency Osteopetrosis) among the sclerosing bone disorders [PDF]
Michael P. Whyte+5 more
openalex +1 more source
Glutamic–alanine and glutamic–aspartic transaminases of wheat germ [PDF]
F. A. Isherwood, D. H. Cruickshank
openaire +3 more sources
Enhancing radiosensitization, modulating the tumor immune microenvironment, and ensuring complete resection are crucial for colorectal cancer (CRC) treatment. This study presents a multifunctional NIR‐II fluorescent nanoprobe, RVLu@ICG, which enhances radiosensitization, remodels the tumor immune microenvironment, and enables precise image‐guided ...
Yongying Dang+10 more
wiley +1 more source
Aspartate transaminase to platelet ratio index in hepatitis C virus and Schistosomiasis coinfection. [PDF]
Derbala M+9 more
europepmc +1 more source
Role of the Aspartate Transaminase and Platelet Ratio Index in Assessing Hepatic Fibrosis and Liver Inflammation in Adolescent Patients with HBeAg-Positive Chronic Hepatitis B [PDF]
Zhijian Yu+11 more
openalex +1 more source
Fibrosis‐3 index (FIB‐3) can stratify the risk of the survival and the recurrence‐free survival. The FIB‐3 index is a reliable, age‐independent tool for assessing liver fibrosis and prognosis in HCC patients post‐hepatectomy. Its use may improve clinical outcomes and support personalized treatment strategies. Abstract Background Liver fibrosis is a key
Yuki Imaoka+13 more
wiley +1 more source
Association between serum alanine transaminase/aspartate aminotransferase (ALT/AST) ratio and cognitive impairment in US older adults [PDF]
Xinping Wang, Xiaoyan Lu
openalex +1 more source
Alterations of Hematological Parameters, Hemoglobin and Hematocrit With Liver Enzymes, Aspartate Transaminase and Alanine Transaminase Among Patients With Chronic Kidney Disease Undergoing Hemodialysis in Aljouf Region, Saudi Arabia [PDF]
Mohammad N. Khan, Abozer Y. Elderdery
openalex +1 more source