Results 191 to 200 of about 192,345 (324)

The Association Between Aspartate Transaminase to Alanine Transaminase Ratio and Perioperative Ischemic Stroke in Patients With Diabetes: A Retrospective Cohort Study. [PDF]

CNS Neurosci Ther
Liu S, Wang B, Ma L, Yang H, Liu M, Song Y, Zhou Z, Lou J, Zhou D, Cao J, Liu Y, Mi W, Ma Y.   +12 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Reveals PIK3CA Inhibition Enhances Lipid Nanoparticle‐Mediated siRNA Delivery

Advanced Science, EarlyView.
A genome‐wide CRISPR screen and identifies PIK3CA as a key regulator of lipid nanoparticle (LNP) uptake is performed. Modulating PIK3CA with small‐molecule inhibitor BAY1082439 enhanced LNP uptake, siRNA delivery, and gene silencing in a variety of epithelial cells, and improved therapeutic outcomes in vivo.
Wenhan Wang, Kangfu Chen, Zongjie Wang
wiley   +1 more source

Prediction of hepatic fibrosis using the aspartate transaminase-to-platelet ratio index in children and adolescents with metabolic dysfunction-associated steatotic liver disease. [PDF]

BMC Pediatr
Jin HY, Noh ES, Jeong H, Hwang IIT.
europepmc   +1 more source

Prognostic value of aspartate transaminase to alanine transaminase (De Ritis) ratio in solid tumors: a pooled analysis of 9,400 patients. [PDF]

Onco Targets Ther, 2019
Wu J, Chen L, Wang Y, Tan W, Huang Z, Huang Z.   +5 more
europepmc   +1 more source

Aspartate aminotransferase - risk marker for type-2 diabetes mellitus or red herring? [PDF]

, 2014
Abbasi, Ahn, André, Begg, Doi, Egger, Fraser, Giannini, Goessling, Hanley, Higgins, Jiamjarasrangsi, Kunutsor, Monami, Nakanishi, Nannipieri, Rahmioglu, Robins, Sato, Schneider, Tonelli, Whitfield, Whitfield, Wroblewski, Wroblewski   +24 more
core   +2 more sources

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

FibroScan-aspartate transaminase: A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis. [PDF]

World J Gastroenterol
Yin JY, Yang TY, Yang BQ, Hou CX, Li JN, Li Y, Wang Q.   +6 more
europepmc   +1 more source

Changes in plasma alanine transaminase/serum glutamic-pyruvic transaminase, aspartate transaminase/serum glutamic-oxaloacetic transaminase, glutathione transferase, and albumin in rabbits given amoxicillin overdose supplemented with cucumber fruit juice

, 2018
Mathew Folaranmi Olaniyan, Oluwatoyin Ateni   +1 more
openalex   +1 more source

Substrate Induced Changes in the Reactivity of the Sulfhydryl Groups of Aspartate Transaminase [PDF]

, 1969
I. Karni-Katsadimas, Constantin G. Dimitropoulos, Athanasios E. Evangelopoulos   +2 more
openalex   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source