Results 41 to 50 of about 172,803 (295)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Genome-Wide Association Study of Liver Enzymes in Korean Children [PDF]

Genomics & Informatics, 2013
Liver enzyme elevations, as an indicator of liver function, are widely associated with metabolic diseases. Genome-wide population-based association studies have identified a genetic susceptibility to liver enzyme elevations and their related traits ...
Tae-Joon Park, Joo-Yeon Hwang, Min Jin Go, Hye-Ja Lee, Han Byul Jang, Youngshim Choi, Jae Heon Kang, Kyung Hee Park, Min-Gyu Choi, Jihyun Song, Bong-Jo Kim, Jong-Young Lee   +11 more
doaj   +1 more source

Developing and Evaluating a Laboratory‐Based Frailty Index for the Prediction of Long‐Term Health Outcomes in Systemic Lupus Erythematosus

Arthritis Care &Research, EarlyView.
Objective We aimed to construct and evaluate the first laboratory‐based frailty index (FI‐Lab) for predicting adverse outcomes in systemic lupus erythematosus (SLE) and to compare its predictive ability to that of an existing clinical FI. Methods We used data from a single‐center prospective cohort of adult patients with SLE whose baseline visit ...
Grace Burns, Samuel D. Searle, Alexandra Legge   +2 more
wiley   +1 more source

Traceability of values for catalytic activity concentration of enzymes : a certified reference material for aspartate transaminase

, 2010
Background: A new reference material for the liver enzyme aspartate transaminase (AST) (L-aspartate: 2-oxoglutarate-aminotransferase, EC 2.6.1.1), also called aspartate aminotransferase (ASAT), has been developed under the code ERM-AD457/IFCC.
M. Panteghini, C. A. Ferrero, F. Canalias, G. Férard, F. J. Gella, S. Bossert Reuther, D. Mazziotta, P. F. Franck, P. J. Jørgensen, B. Toussaint, J. Henny, R. Klauke, F. Ceriotti, J. M. Lessinger, H. G. Schimmel, S. Ueda, G. Schumann, H. Emons   +17 more
core   +2 more sources

Effect of levamisole, Vitamin E, and selenium against aflatoxicosis in broilers chicken [PDF]

Veterinary World, 2018
Aim: The experiment was conducted to determine of levamisole (0.2 ml/kg-BW), Vitamin E (80 mg)+selenium (1.6 mg), and aflatoxin (B1) (positive control) compared with group without aflatoxin (negative control) on some liver enzymes (aspartate transaminase
Amjed H. Ulaiwi
doaj   +1 more source

Inactivation of Glutamie-Aspartic Transaminase by Irradiation.

Experimental Biology and Medicine, 1946
SummaryGlutamic-aspartic transaminase is inactivated by sunlight and by ultraviolet light. Destruction of enzymatic activity by these agents parallels the destruction of vitamin B6, a derivative of which is present as the prosthetic group of the enzyme.1234 The irradiated enzyme is not reactivated by addition of pyridoxine, pyridoxal, pyridox-amine or ...
F, SCHLENK, A, FISHER, E E, SNELL
openaire   +2 more sources

Pseudocholinesterase, aspartate transaminase, alanine transaminase as markers for cervical cancer: a study in a tertiary care hospital

, 2017
Background: Cervical cancer is a malignant neoplasm arising from cells originating in the cervix, almost always caused by human papillomavirus (HPV). Butyrylcholinesterase is a non-specific cholinesterase enzyme that hydrolyses different choline esters ...
Vydehi Veeramalla
core   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Levels of alanine transaminase (ALT), aspartate transaminase (AST) and lactate dehydrogenase (LDH) in the serum of naïve (control) mice and mice after a single irradiation and treatment with PBS, IL-11 and H11.

, 2016
Levels of alanine transaminase (ALT), aspartate transaminase (AST) and lactate dehydrogenase (LDH) in the serum of naïve (control) mice and mice after a single irradiation and treatment with PBS, IL-11 and H11.
Anna Lewandowska (2657563), Andrzej Marszalek (507884), Sebastian Adamczyk (2657566), Katarzyna Gryska (2657569), Hanna Dams-Kozlowska (2657578), Anna Kowalik (2657560), Ewa Leporowska (2657575), Andrzej Mackiewicz (2657572), Eliza Kwiatkowska-Borowczyk (2657557)   +8 more
core   +1 more source

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source