Results 101 to 110 of about 484,668 (401)

Formulation and Characterization of Novel Ionizable and Cationic Lipid Nanoparticles for the Delivery of Splice‐Switching Oligonucleotides

Advanced Materials, EarlyView.
Lipid nanoparticles (LNPs) of unconventional composition and defined structures are investigated as small oligonucleotide carriers. A composition is identified that outperforms Onpattro in cargo delivery to HeLa cells. The structure of these LNPs resembles a micellar cubic phase not commonly associated with high‐performing LNPs.
Miina Ojansivu, Hanna M. G. Barriga, Margaret N. Holme, Stefanie Morf, James J. Doutch, Samir EL Andaloussi, Tomas Kjellman, Markus Johnsson, Justas Barauskas, Molly M. Stevens   +9 more
wiley   +1 more source

Influence of oxygen concentration on the metabolism of Penicillium chrysogenum

Engineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023
Abstract In large‐scale bioreactors, there is often insufficient mixing and as a consequence, cells experience uneven substrate and oxygen levels that influence product formation. In this study, the influence of dissolved oxygen (DO) gradients on the primary and secondary metabolism of a high producing industrial strain of Penicillium chrysogenum was ...
Agnes Janoska, Jelle J. Verheijen, Wenjung Tang, Queenie Lee, Baukje Sikkema, Walter M. van Gulik   +5 more
wiley   +1 more source

Comparison of multiple typing methods for Aspergillus fumigatus [PDF]

, 2009
As part of studies on the spread of infections, risk factors and prevention, several typing methods were developed to investigate the epidemiology of Aspergillus fumigatus. In the present study, 52 clinical isolates of A.
Coenye, Tom, Jacobsen, MD, Nelis, Hans, Symoens, F, Vanhee, Lies   +4 more
core   +1 more source

Azole Resistance in Aspergillus fumigatus: A Consequence of Antifungal Use in Agriculture?

Frontiers in Microbiology, 2017
Agricultural industry uses pesticides to optimize food production for the growing human population. A major issue for crops is fungal phytopathogens, which are treated mainly with azole fungicides.
S. Berger, Yassine El Chazli, A. F. Babu, A. Coste   +3 more
semanticscholar   +1 more source

Stress Response of Aspergillus niger Spores to Copper Surfaces and the Implications for Antifungal Surface Functionalization

Advanced Materials Interfaces, EarlyView.
This study investigates the antifungal efficacy of ultrashort pulsed laser‐induced periodic surface structures (USP‐DLIP) on copper, brass, and steel surfaces. Using Aspergillus niger as a model, the research highlights a 99% reduction in spore viability on 9 µm structured copper surfaces due to enhanced copper ion release. Scanning electron microscopy
Stella Marie Timofeev, Katharina Siems, Daniel Wyn Müller, Aisha Saddiqa Ahmed, Alessa Schiele, Kristina Brix, Carolin Luisa Krämer, Franca Arndt, Ralf Kautenburger, Frank Mücklich, Stefan Leuko   +10 more
wiley   +1 more source

Artificial microbial consortia for bioproduction processes

Engineering in Life Sciences, Volume 23, Issue 1, January 2023., 2023
Abstract The application of artificial microbial consortia for biotechnological production processes is an emerging field in research as it offers great potential for the improvement of established as well as the development of novel processes. In this review, we summarize recent highlights in the usage of various microbial consortia for the production
Fabian Mittermeier, Miriam Bäumler, Prasika Arulrajah, José de Jesús García Lima, Sebastian Hauke, Anna Stock, Dirk Weuster‐Botz   +6 more
wiley   +1 more source

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Angewandte Chemie, EarlyView.
Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy   +11 more
wiley   +2 more sources

Regulation of Folate Metabolizing Enzymes In Fungus Aspergillus nidulans

Pteridines, 1993
The regulation of methionine synthase. serine hydroxymethyltransferase. methylenetetrahydrofolate oxidorelluctase and dihydrofolate reductase in Aspergillus nidulans have been found to be controlled by endogenous pools methionine and homocysteine ...
Balińska Malgorzata, Natorff Renata, Paszewski Andrzej   +2 more
doaj   +1 more source

Study of fungal rhinosinusitis

Journal of Dr. NTR University of Health Sciences, 2020
Background: Rhinosinusitis is a common disorder occurring in 20% of the population. Chronic sinus infection unresponsive to antibiotics should raise the suspicion of Fungal rhinosinusitis. Various types of fungi caused inflammation of sinus mucosa.
Padmavathi Devi Chaganti, Natta B Rao, Karri M Devi, B Janani, Pamidipalli V Vihar, Govada Neelima   +5 more
doaj   +1 more source

Degradation of crude oil and pure hydrocarbon fractions by some wild bacterial and fungal species [PDF]

arXiv, 2023
The use of biodegradation as a method for cleaning up soil that has been contaminated by spilt petroleum can be an effective strategy. So, this study investigated the existence of the wild microorganism in soil contaminated with oil and study their ability to degrade petroleum in vitro.
arxiv