Results 161 to 170 of about 225,540 (315)

Novel Quinazolinones Active against Multidrug‐Resistant Mycobacterium Tuberculosis: Synthesis, Antimicrobial Evaluation, and in Silico Exploration of Penicillin‐Binding Protein 1A as a Potential Target

open access: yesChemMedChem, Volume 20, Issue 13, July 1, 2025.
Quinazolinone‐based compounds emerge as potent antimycobacterial agents, showing low minimum inhibitory concentrations against drug‐resistant Mycobacterium tuberculosis. Molecular modeling uncovers a novel allosteric site in PonA1 targeted by these derivatives.
Marek Kerda   +15 more
wiley   +1 more source

Nutritional, Pharmacological and Industrial Applications of Mangosteen and Passion Fruit: A Review

open access: yesFood Science &Nutrition, Volume 13, Issue 7, July 2025.
The objective of this review was to comprehensively discover the pharmacological, industrial, and nutritional solicitations of passion fruit and mangosteen, the importance of their functional foods, and their therapeutic potential. This study investigated their pharmacological activities, including antioxidant, antidiabetic, anticancer, antibacterial ...
Muhammad Tayyab Arshad   +14 more
wiley   +1 more source

Biological and Computational Study of the Dual Antimicrobial and Anticancer Potential of 3,4‐Dihydropyrimidin‐2(1H)‐ones and Thiones

open access: yesChemistrySelect, Volume 10, Issue 26, July 11, 2025.
Sixteen 3,4‐dihydropyrimidin‐2(1H)‐ones and ‐thiones were synthesized and evaluated for antimicrobial activity against both resistant and nonresistant bacterial strains, as well as for fungal species. Two compounds 16 and 25 inhibiting biofilm formation by 70.22%, and 54.67%, respectively. 20 and 24 were the most potent as antibacterial and antifungal.
Natalia Ciobanu   +13 more
wiley   +1 more source

Phage‐Antibiotic Combinations for Pseudomonas: Successes in the Clinic and In Vitro Tenuously Connected

open access: yesMicrobial Biotechnology, Volume 18, Issue 7, July 2025.
Phage antibiotic combinations have proven particularly successful against Pseudomonas in the clinic (right) and in the lab (left), but the connections between the two are tenuous. Here, we explore the mechanisms and measurements of the latter and highlight which are likely ill‐suited to treatment success.
Rabia Fatima, Alexander P. Hynes
wiley   +1 more source

N‐Glycosylation—The Behind‐the‐Scenes ‘Manipulative Hand’ of Plant Pathogen Invasiveness

open access: yesMolecular Plant Pathology, Volume 26, Issue 7, July 2025.
The potential pathogenic mechanisms related to growth and development, infection structures, and the secretion of effector proteins influenced by N‐glycosylation modifications are described in detail. ABSTRACT Plant pathogens infect hosts through sophisticated molecular strategies, with N‐glycosylation serving as a critical post‐translational ...
Hao Jiang   +3 more
wiley   +1 more source

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