Results 121 to 130 of about 447,619 (420)
How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men [PDF]
, 2005 Tumours in rodent and human colon share many histological and genetic features. To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, beta-carotene, calcium, and ...
Adell-Carceller +109 more
core +3 more sources
Longitudinal Trajectories of Digital Cognitive Biomarkers for Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Cognitive impairment is one of the most common and debilitating symptoms of relapsing–remitting multiple sclerosis (RRMS). Digital cognitive biomarkers require less time and resources and are rapidly gaining popularity in clinical settings.
Yi Chao Foong +17 more
wiley +1 more source
Journal of the Practice of Cardiovascular Sciences, 2023 Aspirin is the most used antiplatelet agent for secondary prophylaxis of atherosclerotic cardiovascular diseases. Individual variability in aspirin responsiveness has been widely reported.
Nischal N Hegde, Navin Mathew
doaj +1 more source
Evaluating Treatment Prioritization Rules via Rank-Weighted Average Treatment Effects [PDF]
arXiv, 2021 There are a number of available methods for selecting whom to prioritize for treatment, including ones based on treatment effect estimation, risk scoring, and hand-crafted rules. We propose rank-weighted average treatment effect (RATE) metrics as a simple and general family of metrics for comparing and testing the quality of treatment prioritization ...
arxiv
Amniotic Fluid Ingestion Enhances\ud Opioid-Mediated But Not\ud Nonopioid-Mediated Analgesia [PDF]
, 1990 Ingestion of amniotic fluid or placenta by rats has been shown to enhance several types of opioid-mediated analgesia: that induced by morphine, footshock, vaginal/cervical stimulation, and late pregnancy.
Barton, Debra +2 more
core
Effect of Aspirin on Cancer Incidence and Mortality in Older Adults
Journal of the National Cancer Institute, 2020 Background ASPirin in Reducing Events in the Elderly, a randomized, double-blind, placebo-controlled trial of daily low-dose aspirin (100 mg) in older adults, showed an increase in all-cause mortality, primarily due to cancer.
J. McNeil +26 more
semanticscholar +1 more source
Journal of the American Medical Association, 1911 InThe JournalI recently read a communication 1 in regard to idiosyncrasy to aspirin, of which I had an almost parallel case on November 19. On the advice of a friend a young man took a five-grain tablet of aspirin for headache. In about one hour, still suffering, he took another, and then lay down on a cot in his office.
openaire +2 more sources
Arthritis Care &Research, EarlyView.Objective The main objective of this study is to examine the safety of oral acetaminophen at its therapeutic dose in adults aged ≥65 years. Methods This population‐based cohort study used the Clinical Practice Research Datalink‐Gold data. Participants were aged ≥65 years registered with a UK general practice for at least 12 months between 1998 and 2018.
Jaspreet Kaur +5 more
wiley +1 more source
Aspirin resistance in patients with acute coronary syndrome. Part 1
Кардиоваскулярная терапия и профилактика, 2010 Aim. To evaluate the prevalence of aspirin resistance, its clinical features, potential solutions, and prognostic role in patients with acute coronary syndrome (ACS). Material and methods. The study included 51 patients with ACS and ST segment elevation (
N. S. Frolova +4 more
doaj
Principal Stratification with Time-to-Event Outcomes [PDF]
arXiv, 2023 Post-randomization events, also known as intercurrent events, such as treatment noncompliance and censoring due to a terminal event, are common in clinical trials. Principal stratification is a framework for causal inference in the presence of intercurrent events.
arxiv