Results 151 to 160 of about 216,445 (311)

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

Advanced Science, EarlyView.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu, Yawei Shen, Robert J. Barndt, Karim Sallam, Ying Tang, Cameron E. Brown, Xiao Li, Stephen Y. Chan, Joseph C. Wu, Qing Liu, Haodi Wu   +10 more
wiley   +1 more source

Efficacy and Safety of Clopidogrel Versus Aspirin Monotherapy After Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis. [PDF]

Clin Med Insights Cardiol
Cheema AH, Hassan Waseem M, Abideen ZU, Tahir MZ, Saleem F, Nadeem A, Tauseef U, Qasim T, Aimen S, Zahid MB, Thada PK.   +10 more
europepmc   +1 more source

Stroke recurrence among Filipino patients taking aspirin for first‐ever non‐cardioembolic ischemic stroke [PDF]

, 2017
Roland Dominic G. Jamora, Evram V. Corral, Mark Angelo C. Ang, Maria Epifania Collantes, Robert Gan   +4 more
openalex   +1 more source

Domestication of Tartary Buckwheat Shaped a Regulatory Module for Seedling Salt Tolerance by Targeting the Magnesium Transporter Gene FtMGT2

Advanced Science, EarlyView.
Domestication of Tartary buckwheat is selected for a salt tolerance mechanism involving the magnesium transporter FtMGT2. Its expression is controlled by the FtAGL16‐FtMYB15L module, which is stabilized under salt stress through a competitive interaction that blocks its degradation by the E3 ligase FtBRG1, ultimately boosting Na⁺ efflux and plant ...
Xiang Lu, Yuqi He, Wenfeng Weng, Zebin Liu, Yuanfen Gao, Yaliang Shi, Wei Li, Dili Lai, Mengyu Zhao, Rintu Jha, Hui Zhao, Guangsheng Li, Chaonan Guan, Shuai Shao, Jingjun Ruan, Sun Hee Woo, Yinan Ouyang, Muriel Quinet, Milen I. Georgiev, Alisdair R. Fernie, Congcong Hou, Kaixuan Zhang, Xu Liu, Meiliang Zhou   +23 more
wiley   +1 more source

Low-Dose Aspirin Induced Gastric Ulcer in a Patient With TIA: A Clinical Caution for Aspirin Therapy Without Gastroprotection. [PDF]

Clin Case Rep
Husain K, Ibrahim M, Bibi F, El Abdi K, Aslam B, Saud A, Maham Hassan V, Betanai A, Muneeb M, Sadat SH.   +9 more
europepmc   +1 more source

High‐Performance Quasi‐Solid‐State Calcium‐Ion Batteries from Redox‐Active Covalent Organic Framework Electrolytes

Advanced Science, EarlyView.
Quasi‐solid‐state calcium‐ion batteries (QSSCIBs) employing redox‐active covalent organic frameworks (COFs) based electrolytes are developed. The COFs’ crystalline porous structures, featuring aligned carbonyl groups, enabled high Ca2⁺ conductivity, supported by molecular dynamics simulations of the ion transport mechanism.
Zhuoyu Yin, Jixin Wu, Ye Tian, Yufei Yuan, Muhua Gu, Lei Cheng, Yanming Wang, Yoonseob Kim   +7 more
wiley   +1 more source

Effectiveness and Safety of Direct Oral Anticoagulants versus Aspirin in Patients with Non-Valvular Atrial Fibrillation and Intermediate Stroke Risk. [PDF]

Clin Appl Thromb Hemost
Park S, Je NK.
europepmc   +1 more source

PCI in patients with atrial fibrillation - triple therapy with aspirin, clopidogrel and VKA, a single center experience [PDF]

, 2013
M. Kaiser, Christoph Hehrlein, Christoph Bode, Ingo Ahrens   +3 more
openalex   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Analysis of Treatment Pattern of Antiplatelet in First-Ever Ischemic Stroke Without Previous Antiplatelet Use: A Real-World Distributed Network Analysis of 11 Observational Korean Databases Using a Common Data Model. [PDF]

J Korean Med Sci
Park SH, Lee KJ, Kim J, Seo SI, Lee DY, Park RW, Rhee SY, Cha JM, Yang HJ, Jang JW, Jung S, Lee J, Lee M, Lee SH, Kim C, Bae JS, Kim YJ, Lee JH, Kim Y.   +18 more
europepmc   +1 more source