DON‐Loaded Nanodrug‐T Cell Conjugates With PD‐L1 Blockade for Solid Tumor Therapy
This study establishes DON‐loaded T cell‐nanodrug conjugates with PD‐L1 blockade, creating a synergistic system. As a glutamine antagonist, sustained DON release enhances T‐cell endurance and infiltration by promoting memory differentiation and upregulating adhesion and motility genes, while PD‐L1 blockade alleviates immunosuppression and directs T ...
Xin Yang+13 more
wiley +1 more source
Aspirin inhibits development of coronary atherosclerosis in cynomolgus monkeys (Macaca fascicularis) fed an atherogenic diet. [PDF]
R Pick, Juan Chediak, G Glick
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Antithrombotic Therapy for Acute Coronary Syndrome. [PDF]
Toyota T+4 more
europepmc +1 more source
In this work, a series of single‐site metal phthalocyanine catalysts (MPcs (M = Zn, Co, Ni, Cu, and Fe)) are screened to learn their activity‐selectivity relationship in the co‐reduction reaction of CO2 and nitrates toward urea formation, which can be significantly promoted by enhanced adsorption of *HOOCNO, reduced adsorptions of *N and *COOH, and ...
Qinglan Zhao+11 more
wiley +1 more source
Is aspirin effective and safe for venous thromboembolism prophylaxis after total hip and knee replacement? [PDF]
Atik OŞ.
europepmc +1 more source
EccDNA‐Driven VPS41 Amplification Alleviates Genotoxic Stress via Lysosomal KAI1 Degradation
Following ionizing radiation, eccDNA‐mediated VPS41 amplification slightly increases its expression but fails to prevent apoptosis. Introducing exogenous eccDNA or VPS41 enhances VPS41‐KAI1 interaction, promoting lysosomal degradation of KAI1. This process inhibits apoptotic signaling, enhancing cell survival and resistance to radiation‐induced damage.
Bin Shi+12 more
wiley +1 more source
Effects of collagen and of aspirin on the concentration of guanosine 3′:5′-cyclic monophosphate in human blood platelets: measurement by a prelabelling technique (Short Communication) [PDF]
Richard J. Haslam, M McClenaghan
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Role of Aspirin in Reducing Risk for Atherosclerotic Cardiovascular Disease in Individuals with Elevated Lipoprotein(a). [PDF]
Razavi AC, Bhatia HS.
europepmc +1 more source
Water‐Catalytic Deconstructive and Proton Transfer Cyclopropanation of Sulfoxonium Ylide with Olefin
Water‐catalytic deconstructive and proton transfer cyclopropanation of sulfoxonium ylide with olefin is developed through a sequential water‐mediated ring‐closing/opening reaction. This atom‐economical, environmentally friendly methodology offers easy access to a range of cyclopropyl ketones with moderate to good yields.
Xianglin Yu+4 more
wiley +1 more source