Results 381 to 390 of about 447,619 (420)
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The Lancet, 2006
Aspirin resistance is the inability of aspirin to reduce platelet production of thromboxane A2 and thereby platelet activation and aggregation. Increasing degrees of aspirin resistance may correlate independently with increasing risk of cardiovascular events.
Hankey Graeme J, Eikelboom John W
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Aspirin resistance is the inability of aspirin to reduce platelet production of thromboxane A2 and thereby platelet activation and aggregation. Increasing degrees of aspirin resistance may correlate independently with increasing risk of cardiovascular events.
Hankey Graeme J, Eikelboom John W
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Lack of aspirin effect: aspirin resistance or resistance to taking aspirin?
American Heart Journal, 2004A lack of aspirin effect on platelets after a myocardial infarction (MI) is associated with poor health outcome. This lack of effect may be due to biological resistance to aspirin or due to nonadherence (the patient is not taking the aspirin, hence it has no effect).
Rikardo Krakover +9 more
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2002
Inhibition of TXA2-dependent platelet fuction by aspirin may lead to prevention of thrombosis as well as to excess bleeding.
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Inhibition of TXA2-dependent platelet fuction by aspirin may lead to prevention of thrombosis as well as to excess bleeding.
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Herz Kardiovaskuläre Erkrankungen, 2008
Recent clinical studies have shown that the expected antiplatelet effect of aspirin is not always achieved. From the laboratory point of view, resistance to aspirin is the inability to achieve the expected inhibition of platelet cyclooxygenase-(COX-)1 with prevention of platelet thromboxane (TX) A2 formation.
Norbert Zimmermann +2 more
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Recent clinical studies have shown that the expected antiplatelet effect of aspirin is not always achieved. From the laboratory point of view, resistance to aspirin is the inability to achieve the expected inhibition of platelet cyclooxygenase-(COX-)1 with prevention of platelet thromboxane (TX) A2 formation.
Norbert Zimmermann +2 more
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Inhibition of NF-kappa B by sodium salicylate and aspirin.
Science, 1994The transcription factor nuclear factor-kappa B (NF-kappa B) is critical for the inducible expression of multiple cellular and viral genes involved in inflammation and infection including interleukin-1 (IL-1), IL-6, and adhesion molecules.
E. Kopp, S. Ghosh
semanticscholar +1 more source
JAMA: The Journal of the American Medical Association, 1980
To the Editor.— The authors of the Aspirin Myocardial Infarction Study (AMIS) (243:661, 1980) state that the regular administration of aspirin in a dosage of 1.0 g/day does not reduce three-year mortality in patients with a history of myocardial infarction (MI). There is no reason to doubt this.
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To the Editor.— The authors of the Aspirin Myocardial Infarction Study (AMIS) (243:661, 1980) state that the regular administration of aspirin in a dosage of 1.0 g/day does not reduce three-year mortality in patients with a history of myocardial infarction (MI). There is no reason to doubt this.
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Annals of Internal Medicine, 1969
Excerpt A recent paper on structural changes in human serum albumin (HSA) induced by acetylsalicylic acid (1) raises additional questions about the differences between aspirin and other salicylates...
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Excerpt A recent paper on structural changes in human serum albumin (HSA) induced by acetylsalicylic acid (1) raises additional questions about the differences between aspirin and other salicylates...
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Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs.
Nature: New biology, 1971J. Vane
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JAMA: The Journal of the American Medical Association, 1970
To the Editor.— Real progress in improving the lot of the hemophiliac depends on a broad understanding of his disease and on the utilization of those clinical observations that have contributed to the establishment of sound therapy. Unfortunately, the editorial on "Hemophilia Prophylaxis" ( 212 :2256-2257, 1970) failed in both aspects.
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To the Editor.— Real progress in improving the lot of the hemophiliac depends on a broad understanding of his disease and on the utilization of those clinical observations that have contributed to the establishment of sound therapy. Unfortunately, the editorial on "Hemophilia Prophylaxis" ( 212 :2256-2257, 1970) failed in both aspects.
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JAMA: The Journal of the American Medical Association, 1971
To the Editor:— My observation that aspirin increases the bleeding time and accentuates the bleeding tendency in bleeders sensitive to the drug, 1 and can thus greatly worsen their clinical state, has not made the impact it warrants. This is clearly pointed out by the editorial on "Aspirin and Gastric Hemorrhage" ( 215 :790, 1971) and the article on ...
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To the Editor:— My observation that aspirin increases the bleeding time and accentuates the bleeding tendency in bleeders sensitive to the drug, 1 and can thus greatly worsen their clinical state, has not made the impact it warrants. This is clearly pointed out by the editorial on "Aspirin and Gastric Hemorrhage" ( 215 :790, 1971) and the article on ...
openaire +3 more sources