Results 81 to 90 of about 372,006 (379)

Apixaban Enhances Endogenous Fibrinolysis in Patients with Atrial Fibrillation [PDF]

, 2019
© The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.AIMS: Approximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which ...
Arachchillage, Deepa RJ, Farag, Mohamed, Gorog, Diana, Gue, Ying X., Lip, Gregory Y H, Spinthakis, Nikolaos, Srinivasan, Manivannan, Wellsted, David   +7 more
core   +2 more sources

Bioinformatic Scaling of Allosteric Interactions in Biomedical Isozymes [PDF]

, 2015
Allosteric (long-range) interactions can be surprisingly strong in proteins of biomedical interest. Here we use bioinformatic scaling to connect prior results on nonsteroidal anti-inflammatory drugs to promising new drugs that inhibit cancer cell metabolism.
arxiv   +1 more source

ASPIRIN IN PNEUMONIA. [PDF]

The Lancet, 1911
n ...
openaire   +3 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Machine Learning of Accurate Energy-Conserving Molecular Force Fields [PDF]

Science Advances 3(5):e1603015 (2017), 2016
Using conservation of energy - a fundamental property of closed classical and quantum mechanical systems - we develop an efficient gradient-domain machine learning (GDML) approach to construct accurate molecular force fields using a restricted number of samples from ab initio molecular dynamics (AIMD) trajectories.
arxiv   +1 more source

Patients' Global Impression of Change (PGIC) Score Compared to Monthly Migraine Days to Evaluate Treatment Persistence With Anti‐CGRP Monoclonal Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This study assessed whether continued treatment with anti‐CGRP monoclonal antibodies (mAbs) is driven more by reductions in monthly migraine days (MMDs) or patients' global impression of change (PGIC), a patient‐reported outcome. Among 169 patients treated with anti‐CGRP mAbs, 21.3% discontinued due to ineffectiveness. PGIC responders (≥ 5) at
Marina Romozzi, Catello Vollono, Paolo Calabresi, Francesco De Cesaris, Luigi Francesco Iannone   +4 more
wiley   +1 more source

Breakthrough Solution for Antimicrobial Resistance Detection: Surface‐Enhanced Raman Spectroscopy‐based on Artificial Intelligence

Advanced Materials Interfaces, EarlyView., 2023
This review discusses the use of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Artificial Intelligence (AI) for detecting antimicrobial resistance (AMR). Various SERS studies used with AI techniques, including machine learning and deep learning, are analyzed for their advantages and limitations.
Zakarya Al‐Shaebi, Munevver Akdeniz, Awel Olsido Ahmed, Mine Altunbek, Omer Aydin   +4 more
wiley   +1 more source

How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men [PDF]

, 2005
Tumours in rodent and human colon share many histological and genetic features. To know if rodent models of colon carcinogenesis are good predictors of chemopreventive efficacy in humans, we made a meta-analysis of aspirin, beta-carotene, calcium, and ...
Adell-Carceller, Ahn, Alberts, Barbolt, Barbolt, Barnes, Barnes, Baron, Baron, Barsoum, Beaty, Behling, Belbraouet, Benamouzig, Bird, BonithonKopp, Bruce, Bull, Chiu, Chung, Clevers, Colacchio, Colnot, Corpet, Corpet, Craven, Cucherat, Davis, Denis E. Corpet, DeWind, Dorval, Drankhan, Fabrice Pierre, Femia, Fodde, Forman, Gescher, Gill, Green, Greenberg, Harris, Hawk, Hioki, Hofstad, Huerta, Imaida, Jacobs, Karkare, Kinzler, Kritchevsky, Laird, Li, MacLennan, Mahmoud, McIntosh, McKeown-Eyssen, McKeown-Eyssen, McSherry, Miliaras, Molck, Moser, Mutanen, Narayan, Nelson, Newmark, ObermuellerJevic, Orner, Oshima, Pence, Pence, Pence, Pence, Perkins, Pierre, Pierre, Pierre, Pound, Quilliot, Ranhotra, Reddy, Reddy, Reddy, Reichling, Reuter, Sandler, Sansom, Schatzkin, Shaukat, Sinkeldam, Sitrin, Takahashi, Takahashi, Takayama, Temple, Toth, Trinh, Tsukamoto, VinasSalas, Vogelstein, Wargovich, Watanabe, Wei, Wijnands, Williamson, Xing, Yamamoto, Yang, Yang, Yang, Yu   +109 more
core   +3 more sources

Is there a role for oral triple therapy in patients with acute coronary syndromes without atrial fibrillation? [PDF]

, 2020
© 2018 Bentham Science PublishersBACKGROUND: Acute coronary syndrome (ACS) patients, despite treatment with dual antiplatelet therapy (DAPT), have up to 10% risk of recurrent major adverse cardiac events (MACE) in the short term.
Akhtar, Zaki, Farag, Mohamed, Gorog, Diana Adrienne, Spinthakis, Nikolaos   +3 more
core   +1 more source

Is there an ideal way to initiate antiplatelet therapy with aspirin? A crossover study on healthy volunteers evaluating different dosing schemes with whole blood aggregometry

BMC Research Notes, 2011
Background Guidelines recommend an early initiation of aspirin treatment in patients with acute cerebral ischemia. Comparative studies on the best starting dose for initiating aspirin therapy to achieve a rapid antiplatelet effect do not exist.
Overbeck Ursula, Neubauer Horst, Meves Saskia H, Endres Heinz G   +3 more
doaj   +1 more source