Results 61 to 70 of about 359,713 (306)
Thorax, 2000 Aspirin or acetylsalicylic acid (ASA) is still one of the most widely sold drugs in the world and its side effects are well known. Among these, hypersensitivity reactions represent one of the most frequently described since the first report of urticaria and angio-oedema by Hirshberg in 1902.1 The hypersensitivity reactions to aspirin may be divided ...
Nucera, Eleonora +6 more
openaire +4 more sources
Is there a role for oral triple therapy in patients with acute coronary syndromes without atrial fibrillation? [PDF]
, 2018 © 2018 Bentham Science PublishersBACKGROUND: Acute coronary syndrome (ACS) patients, despite treatment with dual antiplatelet therapy (DAPT), have up to 10% risk of recurrent major adverse cardiac events (MACE) in the short term.
Akhtar, Zaki +3 more
core +2 more sources
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Density Functional Theory Study on Chemical Reactivity of Aspirin: Substituent Effect
مجلة بغداد للعلومThere is strong evidence that thrombotic and inflammatory mechanisms play a role in COVID-19 severity. COVID-19 morality may be reduced by common drugs that block these pathways, such as Aspirin. New Aspirin derivatives were suggested by functionalizing
Halah T. Mohammed +4 more
doaj +1 more source
Low-dose aspirin for primary and secondary prevention of cardiovascular events in Denmark 1998–2018
Scientific Reports, 2021 Randomised controlled trials have shown a neutral or even unfavourable risk–benefit balance of aspirin for primary prevention of cardiovascular events. Using Danish nationwide registries, we investigated aspirin use and associated risks during the past ...
Mikkel B. Christensen +5 more
doaj +1 more source
Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells [PDF]
, 2015 Acknowledgments We thank NHS Grampian for financial support of this work.Peer reviewedPublisher ...
Cameron, Gary A. +2 more
core +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Archives of Neurology, 1990 In our recent article, 1 we reviewed the available evidence on aspirin and other antiplatelet agents in the secondary and primary prevention of cardiovascular disease. We concluded that low-dose aspirin should be a possible adjunct, not an alternative, to coronary risk factor management and, in view of its possible side effects, should be prescribed ...
Buring, J +4 more
openaire +2 more sources
Model mass spectrometric study of competitive interactions of antimicrobial bisquaternary ammonium drugs and aspirin with membrane phospholipids [PDF]
, 2013 The aim of the study is to reveal molecular mechanisms of possible activity modulation of antimicrobial bis-quaternary ammonium compounds (BQAC) and aspirin (ASP) through noncovalent competitive complexation under their combined introduction into the ...
Gömöry, Ágnes +3 more
core +2 more sources