Results 51 to 60 of about 239,825 (303)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Density Functional Theory Study on Chemical Reactivity of Aspirin: Substituent Effect

مجلة بغداد للعلوم
There is strong evidence that thrombotic and inflammatory mechanisms play a role in COVID-19 severity. COVID-19 morality may be reduced by common drugs that block these pathways, such as Aspirin. New Aspirin derivatives were suggested by functionalizing
Halah T. Mohammed, Ahmed M. Kamil, Abbas A-Ali Drea, Hayder M. Abduljalil, Waleed K. Alkhafaje   +4 more
doaj   +1 more source

Efficacy and Safety of Low-Dose Aspirin in Polycythemia Vera

, 2004
BACKGROUND: The use of aspirin for the prevention of thrombotic complications in polycythemia vera is controversial. METHODS: We enrolled 518 patients with polycythemia vera, no clear indication for aspirin treatment, and no contraindication to such ...
Landolfi, Raffaele, ROBERTO MARCHIOLI, CARLO PATRONO, CARAMATTI, Cecilia, GIANNI TOGNONI, RAFFAELE LANDOLFI, Patrono, Carlo, HEINZ GISSLINGER, JACK KUTTI   +8 more
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Aspirin "Allergy"-Induced Thrombocytopenia: A Case Report [PDF]

, 2021
Aspirin is clinically widely used to inhibit platelet aggregation after coronary intervention. Herein we describe a case of aspirin-induced thrombocytopenia that may be related to allergy to aspirin. A 47-year-old man developed a delayed hypersensitivity
Xu, Shanshan, Gao, Yadong; https://orcid.org/, Fu, Wei; https://orcid.org/, Xie, Qing; https://orcid.org/, Dong, Xiang, Shanshan Xu, Wei Fu, Qing Xie, Xiang Dong, Yadong Gao   +9 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The Synthesis of Carboxymethyl Amylose Grafted Polyacrylamide and Its Application in Drug Release Aspirin [PDF]

, 2012
Polyacrylamide as a biocompetible polymeric material can be used in modifying drug release of aspirin. But limitations in absorbing water on this polymer can be covered with the addition of carboxymethyl amylose which is having more hydrophilic ...
Noor , Hidayati, Karsono Samuel , Padmawijaya, S, Sumarno, Naila , Amanda, Firman , Kurniawansyah   +4 more
core   +1 more source

Aspirin use and the risk of bleeding complications after therapeutic bronchoscopy

Therapeutic Advances in Respiratory Disease, 2016
Background: Aspirin use has been shown to be safe for patients undergoing certain diagnostic bronchoscopy procedures such as transbronchial biopsies and endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration.
Kassem Harris, Jad Kebbe, Kush Modi, Abdul Hamid Alraiyes, Abhishek Kumar, Kristopher Attwood, Samjot S. Dhillon   +6 more
doaj   +1 more source

Is Long-Term Low-Dose Aspirin Therapy Associated with Renal Dysfunction in Patients with Type 2 Diabetes? JPAD2 Cohort Study. [PDF]

PLoS ONE, 2016
BACKGROUND:Low-dose aspirin is widely recommended for patients at high risk for cardiovascular disease (CVD); however, it remains uncertain whether long-term treatment adversely affects renal function in patients with diabetes.
Sadanori Okada, Takeshi Morimoto, Hisao Ogawa, Mio Sakuma, Hirofumi Soejima, Masafumi Nakayama, Hideaki Jinnouchi, Masako Waki, Yasuhiro Akai, Hitoshi Ishii, Yoshihiko Saito, Investigators for the Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes trial   +11 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source