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Aspirin and Clopidogrel Resistance.
EJIFCC, 2004 Sztriha László Krisztián +3 more
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The Lancet, 2006
Aspirin resistance is the inability of aspirin to reduce platelet production of thromboxane A2 and thereby platelet activation and aggregation. Increasing degrees of aspirin resistance may correlate independently with increasing risk of cardiovascular events.
Hankey Graeme J, Eikelboom John W
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Aspirin resistance is the inability of aspirin to reduce platelet production of thromboxane A2 and thereby platelet activation and aggregation. Increasing degrees of aspirin resistance may correlate independently with increasing risk of cardiovascular events.
Hankey Graeme J, Eikelboom John W
+12 more sources
Is Aspirin Resistance valid? [PDF]
Future Cardiology, 2005 “The clinical impact of aspirin resistance with cardiovascular events is now becoming evident, with aspirin nonresponders having nearly a threefold increased risk of cardiovascular death” Aspirin resistance is an increasingly recognized phenomenon denoting a diminished platelet inhibitory effect of aspirin.
Sasidhar Guthikonda, Neal S. Kleiman
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Herz Kardiovaskuläre Erkrankungen, 2008
Recent clinical studies have shown that the expected antiplatelet effect of aspirin is not always achieved. From the laboratory point of view, resistance to aspirin is the inability to achieve the expected inhibition of platelet cyclooxygenase-(COX-)1 with prevention of platelet thromboxane (TX) A2 formation.
Norbert Zimmermann +2 more
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Recent clinical studies have shown that the expected antiplatelet effect of aspirin is not always achieved. From the laboratory point of view, resistance to aspirin is the inability to achieve the expected inhibition of platelet cyclooxygenase-(COX-)1 with prevention of platelet thromboxane (TX) A2 formation.
Norbert Zimmermann +2 more
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Thrombosis Research, 2007
Aspirin resistance refers to less than expected suppression of thromboxane A(2) production by aspirin and has been reported to be independently associated with an increased risk of adverse cardiovascular events. Possible causes of aspirin resistance include poor compliance, drug interaction, inadequate aspirin dose, increase turnover of platelets ...
Huyen A, Tran +3 more
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Aspirin resistance refers to less than expected suppression of thromboxane A(2) production by aspirin and has been reported to be independently associated with an increased risk of adverse cardiovascular events. Possible causes of aspirin resistance include poor compliance, drug interaction, inadequate aspirin dose, increase turnover of platelets ...
Huyen A, Tran +3 more
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Lack of aspirin effect: aspirin resistance or resistance to taking aspirin?
American Heart Journal, 2004A lack of aspirin effect on platelets after a myocardial infarction (MI) is associated with poor health outcome. This lack of effect may be due to biological resistance to aspirin or due to nonadherence (the patient is not taking the aspirin, hence it has no effect).
Rikardo Krakover +9 more
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Current Atherosclerosis Reports, 2009
Aspirin resistance (AR) still lacks a universally accepted definition, but it may be discussed as either a laboratory phenomenon or a clinical presentation. Laboratory resistance is mainly defined as abnormal platelet response to aspirin, whereas the clinical manifestation is the failure of aspirin to prevent cardiovascular events.
Hitender Jain +3 more
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Aspirin resistance (AR) still lacks a universally accepted definition, but it may be discussed as either a laboratory phenomenon or a clinical presentation. Laboratory resistance is mainly defined as abnormal platelet response to aspirin, whereas the clinical manifestation is the failure of aspirin to prevent cardiovascular events.
Hitender Jain +3 more
openaire +3 more sources
Mechanisms of aspirin resistance
Pharmacology & Therapeutics, 2014Aspirin is integral to the secondary prevention of cardiovascular disease and acts to impair the development of platelet-mediated atherothromboembolic events by irreversible inhibition of platelet cyclooxygenase-1 (COX-1). Inhibition of this enzyme prevents the synthesis of the potent pro-aggregatory prostanoid thromboxane A2.
Floyd, Christopher N., Ferro, Albert
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Aspirin resistance in atherosclerosis
Current Atherosclerosis Reports, 2008Clinically, aspirin resistance is defined as the failure of aspirin therapy to prevent an acute vascular thrombotic event despite regular intake of appropriate doses. In the laboratory, aspirin resistance encompasses the drug's failure to attain a particular level of platelet inhibition. From a clinical standpoint, the inability of aspirin to prevent a
Jane E. Freedman, Price Blair
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